Results 41 to 50 of about 22,284 (219)

Sharpbelly Fish Optimization Algorithm: A Bio-Inspired Metaheuristic for Complex Engineering

Biomimetics
This paper introduces a novel bio-inspired metaheuristic algorithm, named the sharpbelly fish optimizer (SFO), inspired by the collective ecological behaviors of the sharpbelly fish.
Jian Liu, Rong Wang, Yonghong Deng, Xiaona Huang, Zhibin Li   +4 more
doaj   +1 more source

Digital health and self-management of chronic diseases in sub-Saharan Africa: A scoping review

South African Journal of Information Management, 2022
Background: With the rise of noncommunicable diseases (NCDs) in sub-Saharan Africa (SSA), the concept of digital self-management presents great opportunities for relieving some of the burdens healthcare systems face.
Mourine S. Achieng, Oluwamayowa O. Ogundaini   +1 more
doaj   +1 more source

Digital or analog Hough transform? [PDF]

Pattern Recognition Letters, 1990
Abstract A variation of the Hough Transform that is aimed at detecting digital lines has been recently suggested. Other Hough algorithms are intended to detect straight lines in the analog pre-image. These approaches are analyzed and compared in terms of the relation between the achievable resolution and the required number of accumulators, using a ...
Nahum Kiryati, Michael Lindenbaum, Alfred M. Bruckstein   +2 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Model for assessing the maturity level of digital transformation in higher education institutions: a theoretical-methodological approach

Frontiers in Education
In these times of increasing digitization and process automation, digital transformation (DT) has become a determining factor for continuous improvement and competitiveness in organizations in all areas.
Jessie Bravo-Jaico, Roger Alarcón, Carlos Valdivia, Nilton Germán, Janet Aquino, Oscar Serquén, Laurita Guevara, Armando Moreno Heredia   +7 more
doaj   +1 more source

schlably: A Python framework for deep reinforcement learning based scheduling experiments

SoftwareX, 2023
Research on deep reinforcement learning (DRL) based production scheduling (PS) has gained a lot of attention in recent years, primarily due to the high demand for optimizing scheduling problems in diverse industry settings.
Constantin Waubert de Puiseau, Jannik Peters, Christian Dörpelkus, Hasan Tercan, Tobias Meisen   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advancing cell therapy manufacturing: an image-based solution for accurate confluency estimation

Frontiers in Bioengineering and Biotechnology
Cell therapies represent a transformative approach for treating diseases resistant to conventional therapies, yet their development and manufacturing face significant hurdles within the biopharmaceutical sector.
John Mason, Martin Kraft, Jakob Hueckels, Hao Wei, Konstantinos Spetsieris   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source