Results 41 to 50 of about 1,473,665 (331)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2020 Abstract The introductory chapter to the book The Data Imperative examines how technological advances together with a new managerial mindset are driving digital transformation. While early business information systems were often self-contained and designed to solve specific problems, contemporary systems are highly interconnected and ...
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SensorsEnergy measurement in dynamic penetration tests is key to correctly interpreting test results and ensuring comparable geotechnical data. Although commercial devices are widely used, their high cost limits adoption in developing regions such as Peru ...
Carmen Ortiz +5 more
doaj +1 more source
TEE: Real-Time Purchase Prediction Using Time Extended Embeddings for Representing Customer Behavior
Journal of Theoretical and Applied Electronic Commerce Research, 2023 Real-time customer purchase prediction tries to predict which products a customer will buy next. Depending on the approach used, this involves using data such as the customer’s past purchases, his or her search queries, the time spent on a product page ...
Miguel Alves Gomes +3 more
doaj +1 more source
The Dynamics of Transformation in the Development of Digital Services [PDF]
, 2018 Service providers are increasingly depending and using digital infrastructure and tools provided by digital platforms to transform their services and develop digital ones that meet the needs of heterogeneous end users. However, while there is an emerging
Ghazawneh, Ahmad
core +1 more source
Combining confocal and BSE SEM imaging for bone block surfaces [PDF]
, 2005 The present report presents a method for the correlation of qualitative and quantitative BSE SEM imaging with confocal scanning light microscopy (CSLM) imaging modes applied to bone samples embedded in PMMA.
Boyde, A, Lovicar, L, Zamecnik, J
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Digital transformation in government: Lessons for digital health? [PDF]
, 2018 Globally, there is a movement for outstanding digital services in government; in many countries, this extends to healthcare. And if digital health is to be delivered at scale, there needs to be involvement from multiple stakeholders, and government often
Benjamin, K, Potts, HWW
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Sharpbelly Fish Optimization Algorithm: A Bio-Inspired Metaheuristic for Complex Engineering
BiomimeticsThis paper introduces a novel bio-inspired metaheuristic algorithm, named the sharpbelly fish optimizer (SFO), inspired by the collective ecological behaviors of the sharpbelly fish.
Jian Liu +4 more
doaj +1 more source