Results 51 to 60 of about 1,473,665 (331)

schlably: A Python framework for deep reinforcement learning based scheduling experiments

SoftwareX, 2023
Research on deep reinforcement learning (DRL) based production scheduling (PS) has gained a lot of attention in recent years, primarily due to the high demand for optimizing scheduling problems in diverse industry settings.
Constantin Waubert de Puiseau, Jannik Peters, Christian Dörpelkus, Hasan Tercan, Tobias Meisen   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Model for assessing the maturity level of digital transformation in higher education institutions: a theoretical-methodological approach

Frontiers in Education
In these times of increasing digitization and process automation, digital transformation (DT) has become a determining factor for continuous improvement and competitiveness in organizations in all areas.
Jessie Bravo-Jaico, Roger Alarcón, Carlos Valdivia, Nilton Germán, Janet Aquino, Oscar Serquén, Laurita Guevara, Armando Moreno Heredia   +7 more
doaj   +1 more source

Digital health and self-management of chronic diseases in sub-Saharan Africa: A scoping review

South African Journal of Information Management, 2022
Background: With the rise of noncommunicable diseases (NCDs) in sub-Saharan Africa (SSA), the concept of digital self-management presents great opportunities for relieving some of the burdens healthcare systems face.
Mourine S. Achieng, Oluwamayowa O. Ogundaini   +1 more
doaj   +1 more source

Continuous Fourier transform system [PDF]

, 1974
Complex digital computer is not required, only summing amplifiers and attenuators are used for transformation of signal. Continuous transform system may be used for spectrum analysis, filtering, transfer function synthesis, and ...
Munoz, R. M.
core   +1 more source

Artificial Intelligence for Global Health: Learning From a Decade of Digital Transformation in Health Care [PDF]

, 2020
The health needs of those living in resource-limited settings are a vastly overlooked and understudied area in the intersection of machine learning (ML) and health care.
Gichoya, Judy Wawira, Mathur, Varoon, Purkayastha, Saptarshi   +2 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Advancing cell therapy manufacturing: an image-based solution for accurate confluency estimation

Frontiers in Bioengineering and Biotechnology
Cell therapies represent a transformative approach for treating diseases resistant to conventional therapies, yet their development and manufacturing face significant hurdles within the biopharmaceutical sector.
John Mason, Martin Kraft, Jakob Hueckels, Hao Wei, Konstantinos Spetsieris   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

2010 State New Economy Index [PDF]

, 2010
Measures states' economic structures on twenty-six indicators of their competitiveness in the New Economy: the prominence of knowledge jobs, globalization, economic dynamism, transformation to a digital economy, and technological innovation ...

core