Results 81 to 90 of about 337,845 (323)

Digital twin method and application practice of spacecraft system driven by mechanism data [version 2; peer review: 1 approved, 2 approved with reservations]

Digital Twin
Spacecrafts are large-scale systems characterized by various on-orbit configurations, multi-disciplinary coupling, and complex mission modes. Research and exploration on the data-driven spacecraft digital twins development methods must be carried out to ...
Zhou Fanli, Huang Lei, Shang Shuai, Wang Wei, Zhou Haocheng   +4 more
doaj   +1 more source

Enumerating the symplectic Dellac configurations

, 2017
Fang and Fourier defined the symplectic Dellac configurations in order to parametrize the torus fixed points of the symplectic degenerated flag varieties, and conjectured that their numbers are the elements of a sequence of integers (1, 2, 10, 98, 1594, .
Brown, André EX, Ch'ng, Quee-Lim, Currie, Michael, Grundy, Laura J, Hokanson, Jim, Javer, Avelino, Kerr, Rex, Lee, Chee Wai, Li, Chris, Li, Kezhi, Schafer, William R, Yemini, Eviatar   +11 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Towards a shape-performance integrated digital twin for lumbar spine analysis [version 2; peer review: 2 approved, 1 not approved]

Digital Twin
Background With significant advancement and demand for digital transformation, the digital twin has been gaining increasing attention as it is capable of establishing real-time mapping between physical space and virtual space.
Wei Sun, Xueguan Song, Xiwang He, Xiaonan Lai, Yiming Qiu, Liming Shu, Zhonghai Li   +6 more
doaj   +1 more source

Cosmic rays studied with a hybrid high school detector array [PDF]

, 2007
The LORUN/NAHSA system is a pathfinder for hybrid cosmic ray research combined with education and outreach in the field of astro-particle physics. Particle detectors and radio antennae were mainly setup by students and placed on public buildings.
de Vos, C. M., Falcke, H., Horneffer, A., Koopman, Y., Kuijpers, J., Nigl, A., Pepping, H. J., Schellart, P., Schoonderbeek, G., Timmermans, C.   +9 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Construction method of high-horsepower tractor digital twin [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background Agricultural machinery equipment is the core element of advanced agricultural productivity. The operation system of agricultural machinery equipment involves machine-human-environment-society interactions.
Zihan Yang, Yuefeng Du, Zhenghe Song, Du Chen, Zhongxiang Zhu, Yanan Zhang   +5 more
doaj   +1 more source

Complete LibTech 2013 Print Program [PDF]

, 2013
PDF of the complete print program from the 2013 Library Technology ...
Library Technology Conference
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

MO BIDIC - Teletype Interface [PDF]

Device for enabling two-way communication between twin digital computer and ...
Hall, O. R.
core   +1 more source