Results 91 to 100 of about 37,610,272 (251)

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Is the Healthcare Industry Ready for Digital Twins? Examining the Opportunities and Challenges

Future Internet
Recent advancements in the healthcare sector have reached a pivotal juncture, catalysed by the emergence of Digital Twin (DT) technologies. These innovations facilitate the development of virtual replicas that accurately simulate real-world conditions ...
Srinivasini Sasitharasarma, Noor H. S. Alani, Zazli Lily Wisker   +2 more
doaj   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Artificial Intelligence in Digital Twins: Paradigm, Enabling Technologies and Advantages

Digital Twins and Applications
The Industry 4.0 digital transformation propels economic industries from a physical economy to a digital economy. As the cornerstone of the digital economy, digital twins have attracted widespread attention in academic circles. Integrations of artificial
Cong Peng, Bei Li, Jinquan Yang, Jiayin Zhu   +3 more
doaj   +1 more source

The Importance of Metal‐Organic Framework Linker Atoms for CO2 Reduction: A DFT Study

Advanced Science, EarlyView.
Using DFT, we examine the role of linker atoms in CO2 reduction on copper‐based metal organic frameworks (Cu MOFs). Our calculations reveal that linker atoms may serve as both CO2 and H‐shuttling sites and suggest linker electrostatics as a descriptor for linker activity. ABSTRACT Although the metal within the secondary building unit of a metal‐organic
Ugochukwu Nwosu, Samira Siahrostami
wiley   +1 more source

Development of a Digital Twin for a Cartesian Robotic Arm

embargoed_20270411The Digital Twin (DT) paradigm has emerged as a key enabler of industrial innovation, due to its ability to digitally replicate physical systems with the final aim to optimize performance, reduce costs, and support informed decision ...
SEDUSI, MARCO
core  

Ferroelectric Devices for In‐Memory and In‐Sensor Computing

Advanced Science, EarlyView.
Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang, Ronghuan Xie, Qiang Cao, Shishen Yan, Xiaolin Wang, Limei Zheng   +5 more
wiley   +1 more source

Rethinking digital twin: Introducing digital risk twin for disaster risk management

npj Natural Hazards
The digital risk twin (DRT) adapts digital twin (DT) for disaster risk management (DRM) by integrating automated and manual data collection methods, such as IoT, remote sensing, surveys and field observations, while incorporating human-in-the-loop ...
Saman Ghaffarian
doaj   +1 more source

DT-Loong: A Digital Twin Simulation Framework for Scalable Data Collection and Training of Humanoid Robots

Biomimetics
Recent advances in bionic intelligence are reshaping humanoid-robot design, demonstrating unprecedented agility, dexterity and task versatility. These breakthroughs drive an increasing need for large scale and high-quality data.
Yufei Liu, Yang Li, Jinda Du, Yanjie Rui, Yongyao Li   +4 more
doaj   +1 more source