Results 111 to 120 of about 3,646 (265)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

PMI-DT: Leveraging Digital Twins and Machine Learning for Predictive Modeling and Inspection in Manufacturing

CoRR
Over the years, Digital Twin (DT) has become popular in Advanced Manufacturing (AM) due to its ability to improve production efficiency and quality. By creating virtual replicas of physical assets, DTs help in real-time monitoring, develop predictive models, and improve operational performance.
Chas Hamel, Md. Manjurul Ahsan, Shivakumar Raman   +2 more
openaire   +2 more sources

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Real-Time State Evaluation System of Antenna Structures in Radio Telescopes Based on a Digital Twin

Applied Sciences
To enhance the intelligence and digital management level of radio telescopes and ensure the safe and stable operation of antennas, this paper proposes a real-time state evaluation method for the antenna structure of radio telescopes based on digital twin
Hanwei Cui, Binbin Xiang, Shike Mo, Wei Wang, Shangmin Lin, Peiyuan Lian, Wei Wang, Congsi Wang   +7 more
doaj   +1 more source

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

Advanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi, Xiaoyu Han, Yanhui Lu, Yuan Chai, Baiyan Xiao, Shuo Liu, Boon Chin Heng, Tingting Wu, Tingjun Li, Qiaomei Ren, Ting Song, Le Chen, Dong Han, Yaru Guo, Xuliang Deng, Xuehui Zhang   +15 more
wiley   +1 more source

Mitigating Security Threats for Digital Twin Platform: A Systematic Review with Future Scope and Research Challenges

International Journal of Electronics and Communications System
In Industry 4.0, the digital twin (DT) enables users to simulate future states and configurations for prediction, optimization, and estimation. Although the potential of digital twin technology has been demonstrated by its proliferation in traditional ...
Swati Lipsa, Ranjan Kumar Dash, Korhan Cengiz   +2 more
doaj   +1 more source

Polarization‐Enabled Piezoelectric Tellurium–Selenium (TexSe1–x) Thin Films for Memory Switching and Artificial Synaptic Functions

Advanced Science, EarlyView.
Here, we demonstrate and investigate polarization‐enabled electromechanical responses in cryogenic physical vapor deposition (cryogenic PVD)‐deposited TexSe1‐x thin films, a tellurium‐based compound with a tunable bandgap and enhanced non‐centrosymmetry.
Chia‐Chen Chung, Mayur Chaudhary, Chia‐Hung Lo, Po‐Chien Lai, You‐Jie Lin, Ruei‐Hong Cyu, Yu‐Ren Peng, Bing‐Ni Gu, Zhao‐Feng Lou, Quynh Thi Le, Yi‐Jen Yu, Yen‐Fu Lin, Min‐Hung Lee, Ying‐Hao Chu, Chang‐Hong Shen, Der‐Hsien Lien, Yu‐Lun Chueh   +16 more
wiley   +1 more source

A Review on Digital Twins and Its Application in the Modeling of Photovoltaic Installations

Energies
Industry 4.0 is in continuous technological growth that benefits all sectors of industry and society in general. This article reviews the Digital Twin (DT) concept and the interest of its application in photovoltaic installations.
Dorotea Dimitrova Angelova, Diego Carmona Fernández, Manuel Calderón Godoy, Juan Antonio Álvarez Moreno, Juan Félix González González   +4 more
doaj   +1 more source

SoC-DT: Standard-of-Care Aligned Digital Twins for Patient-Specific Tumor Dynamics

CoRR
Accurate prediction of tumor trajectories under standard-of-care (SoC) therapies remains a major unmet need in oncology. This capability is essential for optimizing treatment planning and anticipating disease progression. Conventional reaction-diffusion models are limited in scope, as they fail to capture tumor dynamics under heterogeneous therapeutic ...
Moinak Bhattacharya, Gagandeep Singh, Prateek Prasanna   +2 more
openaire   +2 more sources

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source