Results 131 to 140 of about 37,610,272 (251)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Digital twin, digital thread, and digital mindset in enabling digital transformation: A socio-technical systems perspective

Digital transformation (DT) is revolutionizing industrial businesses, with advanced technologies driving unprecedented change. However, change is uncertain, and industrial managers need clarity on the most effective digital transformation strategies ...
Ian Hodgkinson (7202654), Mathew Hughes (20341947), Swapan Ghosh (8081093), Paul Hughes (2219167)   +3 more
core   +1 more source

Toward Smart Railway Infrastructure Predictive and Optimised Maintenance Through Digital Twin (DT) System. [PDF]

Sensors (Basel)
Kazemi MJ, Rashidi M, Kang WH, Siahkouhi M.   +3 more
europepmc   +1 more source

Polydopamine‐Wool Textiles for Sustainable Interfacial Solar Vapor Generation

Advanced Science, EarlyView.
A natural wool textile engineered for high solar absorbance and a fast‐wicking structure serves as a highly efficient, single‐layer system for interfacial solar vapor generation (ISVG). This integrated evaporator seamlessly couples rapid water transport with continuous evaporation. Ultimately, this sustainable photothermal design offers a scalable, eco‐
Kyuin Park, Jintong Gao, Hansadi Jayamaha, Yipu Wang, Mia Bressler, Lenan Zhang, Larissa M. Shepherd   +6 more
wiley   +1 more source

Correction: Kazemi et al. Toward Smart Railway Infrastructure Predictive and Optimised Maintenance Through Digital Twin (DT) System. <i>Sensors</i> 2026, <i>26</i>, 2333. [PDF]

Sensors (Basel)
Kazemi MJ, Rashidi M, Kang WH, Siahkouhi M.   +3 more
europepmc   +1 more source

Static Drainage H2/O2 PEM Fuel Cells Enabled by Water Transport Plates: Pore‐Scale Design and Transport Mechanisms

Advanced Science, EarlyView.
The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo, Diankai Qiu, Dong Zhu, Linfa Peng   +3 more
wiley   +1 more source

MetaD-DT: A Reference Architecture Enabling Digital Twin Development for Complex Engineering Equipment

Digital twin technology is emerging as a critical enabler for the lifecycle management of complex engineering equipment, yet its implementation faces significant hurdles.
Feng Wang, Yi Gu, Taoping Zhao, Hanyu Gao   +3 more
core   +1 more source

Multi‐Dimensional Physical‐Layer Security via Digitally Mediated Space–Time Modulation

Advanced Science, EarlyView.
Digitally mediated space–time modulation moves radiation control beyond hardware‐bound switching. Multiple information‐bearing and masking waveforms are jointly synthesized at baseband and coherently coupled to simple periodic time modulation, enabling programmable, independently directed multi‐beam radiation without increasing switching‐state ...
Kejin Chen, Heng Mao, Feng Yang, Gengbo Wu, Lei Zhang, Yikai Chen, Shi‐Wei Qu, Jun Hu, Shiwen Yang   +8 more
wiley   +1 more source

Test and Evaluation of AI/ML Enhanced Digital Twin

A Digital Twin (DT) is not just a collection of static digital models at the component level of a physical system, but a dynamic entity that evolves in parallel with the physical system it mirrors.
Afroza Shirin, Jesus Castillo, Mario Reyes Garcia   +2 more
core   +1 more source