Results 51 to 60 of about 20,305 (263)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Digital twins of the Earth with and for humans
Communications Earth & EnvironmentDigital twins of the Earth are digital representations of the Earth system, spanning scales and domains. Their purpose is to monitor, forecast and assess the Earth system and the consequences of human interventions on the Earth system.
W. Hazeleger +27 more
doaj +1 more source
Annual Review of Biomedical EngineeringDigital twins—virtual representations dynamically linked to physical systems—have the potential to transform biomedical engineering by enabling real-time prediction, optimization, and personalization in health and disease. In biofluids, digital twins offer a framework for integrating physics-based models with data from clinical imaging, sensors, and ...
C Alberto, Figueroa +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Feature-Based Framework for Structuring Industrial Digital Twins
IEEE Access, 2020 Digital twin is a virtual entity that is linked to a real-world entity. Both the link and the virtual representation can be realized in several different ways.
Juuso Autiosalo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The crane radar: Development and deployment of an operational eco-digital twin
Ecological InformaticsAs virtual copies of real-world phenomena, digital twins are rapidly gaining popularity in industry, academia and policy. Their main strength is informing decision makers in an operational environment by giving detailed up-to-date information about the ...
K. De Koning
doaj +1 more source
CoRR, 2016 Multiple forms of digital transformation are imminent. Digital Twins represent one concept. It is gaining momentum because it may offer real-time transparency. Rapid diffusion of digital duplicates faces hurdles due to lack of semantic interoperability between architectures, standards and ontologies.
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source