Results 51 to 60 of about 18,427 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

International Standards for Digital Twins

Acta Infologica
Interest in digital twins has grown significantly due to the maturation of enabling technologies, including cloud computing, 5G, data storage, computing capabilities, the Internet of Things (IoT), Artificial Intelligence (AI), and machine learning.
Esra Kumaş
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

Journal of Medical Internet Research
BackgroundThe concept of digital twins, widely adopted in industry, is entering health care. However, there is a lack of consensus on what constitutes the digital twin of a patient.
David Drummond, Apolline Gonsard
doaj   +1 more source

Using digital twins to manage traffic flows [PDF]

E3S Web of Conferences
This paper explores the use of digital twins for traffic flows. Explores how digital twins can be applied to effectively manage traffic flows, including improving road safety, optimizing vehicle flow, and improving overall transportation system ...
Shamlitsky Yaroslav, Aleksey Ovsyankin, Morozov Evgeny, Strekaleva Tatiana   +3 more
doaj   +1 more source

Improving cloud storage and privacy security for digital twin based medical records

Journal of Cloud Computing: Advances, Systems and Applications, 2023
As digital transformation progresses across industries, digital twins have emerged as an important technology. In healthcare, digital twins are created by digitizing patient parameters, medical records, and treatment plans to enable personalized care ...
Haibo Yi
doaj   +1 more source

Digital Twin and 3D Digital Twin: Concepts, Applications, and Challenges in Industry 4.0 for Digital Twin

Computers
The rapid development of digitalization, the Internet of Things (IoT), and Industry 4.0 has led to the emergence of the digital twin concept. IoT is an important pillar of the digital twin. The digital twin serves as a crucial link, merging the physical and digital territories of Industry 4.0.
April Lia Hananto, Andy Tirta, Safarudin Gazali Herawan, Muhammad Idris, Manzoore Elahi M. Soudagar, Djati Wibowo Djamari, Ibham Veza   +6 more
openaire   +2 more sources