Results 51 to 60 of about 128,358 (272)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome. [PDF]

, 2019
BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder that is caused by maternal genetic deficiency of a gene that encodes E6-AP ubiquitin-protein ligase (gene symbol UBE3A) mapping to chromosome 15q11-q13.
Anselm, Irina, Bacino, Carlos A, Bichell, Terry Jo, Bird, Lynne M, Golden, Stephanie, Han, Julia, Kimonis, Virginia, Peters, Sarika U, Waisbren, Susan   +8 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Digital Twins for Healthcare Using Wearables

Bioengineering
Digital twins are a relatively new form of digital modeling that has been gaining popularity in recent years. This is in large part due to their ability to update in real time to their physical counterparts and connect across multiple devices.
Zachary Johnson, Manob Jyoti Saikia
doaj   +1 more source

Using digital twins to manage traffic flows [PDF]

E3S Web of Conferences
This paper explores the use of digital twins for traffic flows. Explores how digital twins can be applied to effectively manage traffic flows, including improving road safety, optimizing vehicle flow, and improving overall transportation system ...
Shamlitsky Yaroslav, Aleksey Ovsyankin, Morozov Evgeny, Strekaleva Tatiana   +3 more
doaj   +1 more source

Digitally Yours; The Body in Contemporary Photography [PDF]

, 2009
This article analyses two artworks by contemporary photographers, Alexa Wright and Wendy McMurdo. It focuses in particular on the relationship between digital technologies and representation of the body, and on the changes to accepted paradigms of ...
Rubinstein, Daniel
core  

Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control [PDF]

, 2016
Background Mental health disorders commonly co-occur, even between conceptually distinct syndromes, such as internalizing and externalizing disorders.
Ellingson, J. M, Martin, N. G, Richmond-Rakerd, L. S, Slutske, W. S, Statham, D. J   +4 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

Journal of Medical Internet Research
BackgroundThe concept of digital twins, widely adopted in industry, is entering health care. However, there is a lack of consensus on what constitutes the digital twin of a patient.
David Drummond, Apolline Gonsard
doaj   +1 more source

A Feature-Based Framework for Structuring Industrial Digital Twins

IEEE Access, 2020
Digital twin is a virtual entity that is linked to a real-world entity. Both the link and the virtual representation can be realized in several different ways.
Juuso Autiosalo, Jari Vepsalainen, Raine Viitala, Kari Tammi   +3 more
doaj   +1 more source