Results 51 to 60 of about 35,324,095 (281)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

Journal of Medical Internet Research
BackgroundThe concept of digital twins, widely adopted in industry, is entering health care. However, there is a lack of consensus on what constitutes the digital twin of a patient.
David Drummond, Apolline Gonsard
doaj   +1 more source

Improving cloud storage and privacy security for digital twin based medical records

Journal of Cloud Computing: Advances, Systems and Applications, 2023
As digital transformation progresses across industries, digital twins have emerged as an important technology. In healthcare, digital twins are created by digitizing patient parameters, medical records, and treatment plans to enable personalized care ...
Haibo Yi
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Digital Twin and 3D Digital Twin: Concepts, Applications, and Challenges in Industry 4.0 for Digital Twin

Computers
The rapid development of digitalization, the Internet of Things (IoT), and Industry 4.0 has led to the emergence of the digital twin concept. IoT is an important pillar of the digital twin. The digital twin serves as a crucial link, merging the physical and digital territories of Industry 4.0.
April Lia Hananto, Andy Tirta, Safarudin Gazali Herawan, Muhammad Idris, Manzoore Elahi M. Soudagar, Djati Wibowo Djamari, Ibham Veza   +6 more
openaire   +2 more sources

Using digital twins to manage traffic flows [PDF]

E3S Web of Conferences
This paper explores the use of digital twins for traffic flows. Explores how digital twins can be applied to effectively manage traffic flows, including improving road safety, optimizing vehicle flow, and improving overall transportation system ...
Shamlitsky Yaroslav, Aleksey Ovsyankin, Morozov Evgeny, Strekaleva Tatiana   +3 more
doaj   +1 more source

Digital Human Twins: Our Future Data Selves (Plenary Keynote)

This keynote explored the evolving concept of Digital Human Twins as the next frontier in self-representation, with a particular focus on the convergence of data, technology, and the human body.
Boddington, Ghislaine
core   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Digital twins of the Earth with and for humans

Communications Earth & Environment
Digital twins of the Earth are digital representations of the Earth system, spanning scales and domains. Their purpose is to monitor, forecast and assess the Earth system and the consequences of human interventions on the Earth system.
W. Hazeleger, J. P. M. Aerts, P. Bauer, M. F. P. Bierkens, G. Camps-Valls, M. M. Dekker, F. J. Doblas-Reyes, V. Eyring, C. Finkenauer, A. Grundner, S. Hachinger, D. M. Hall, T. Hartmann, F. Iglesias-Suarez, M. Janssens, E. R. Jones, T. Kölling, M. Lees, S. Lhermitte, R. V. van Nieuwpoort, A.-K. Pahker, O. J. Pellicer-Valero, F. P. Pijpers, A. Siibak, J. Spitzer, B. Stevens, V. V. Vasconcelos, F. C. Vossepoel   +27 more
doaj   +1 more source

A Feature-Based Framework for Structuring Industrial Digital Twins

IEEE Access, 2020
Digital twin is a virtual entity that is linked to a real-world entity. Both the link and the virtual representation can be realized in several different ways.
Juuso Autiosalo, Jari Vepsalainen, Raine Viitala, Kari Tammi   +3 more
doaj   +1 more source