Results 51 to 60 of about 37,303,817 (298)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Urban digital twins: Digital twins for participatory steering

open access: yesNew Media & Society
Originating in the field of manufacturing, the Digital Twin (DT) concept is now being applied across a range of application domains, from personal healthcare to whole Earth observation. Despite enthusiasm for DTs, uncertainties have arisen concerning their lack of definition and technical specificity.
Oliver Dawkins, Rob Kitchin
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Digital Twins for Healthcare Using Wearables

open access: yesBioengineering
Digital twins are a relatively new form of digital modeling that has been gaining popularity in recent years. This is in large part due to their ability to update in real time to their physical counterparts and connect across multiple devices.
Zachary Johnson, Manob Jyoti Saikia
doaj   +1 more source

A Feature-Based Framework for Structuring Industrial Digital Twins

open access: yesIEEE Access, 2020
Digital twin is a virtual entity that is linked to a real-world entity. Both the link and the virtual representation can be realized in several different ways.
Juuso Autiosalo   +3 more
doaj   +1 more source

Smart City and Digital Twins

open access: yes, 2021
The chapter proposed aims at facing the various implications underlying the smart city concept based on digital twins. The structure of the text is articulated in three main themes: the use of the term “smart city” and the role that technologies had in
Sara Giaveno, Giaveno, Sara.
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

open access: yesJournal of Medical Internet Research
BackgroundThe concept of digital twins, widely adopted in industry, is entering health care. However, there is a lack of consensus on what constitutes the digital twin of a patient.
David Drummond, Apolline Gonsard
doaj   +1 more source

Improving cloud storage and privacy security for digital twin based medical records

open access: yesJournal of Cloud Computing: Advances, Systems and Applications, 2023
As digital transformation progresses across industries, digital twins have emerged as an important technology. In healthcare, digital twins are created by digitizing patient parameters, medical records, and treatment plans to enable personalized care ...
Haibo Yi
doaj   +1 more source

Digital Twin and 3D Digital Twin: Concepts, Applications, and Challenges in Industry 4.0 for Digital Twin

open access: yesComputers
The rapid development of digitalization, the Internet of Things (IoT), and Industry 4.0 has led to the emergence of the digital twin concept. IoT is an important pillar of the digital twin. The digital twin serves as a crucial link, merging the physical and digital territories of Industry 4.0.
April Lia Hananto   +6 more
openaire   +2 more sources

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