Results 61 to 70 of about 35,324,095 (281)

Managing Intellectual Property Issues with Digital Twins

, 2021
The application of Digital Twins is increasing across industry sectors from transport, energy, built environment, medical and health to manufacturing. The potential benefits of Digital Twins for understanding, anticipating and influencing behaviours of ...
Clementson, J.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The crane radar: Development and deployment of an operational eco-digital twin

Ecological Informatics
As virtual copies of real-world phenomena, digital twins are rapidly gaining popularity in industry, academia and policy. Their main strength is informing decision makers in an operational environment by giving detailed up-to-date information about the ...
K. De Koning
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Characterizing the Digital Twin in Structural Mechanics

Designs
The Digital Twin is one of the major technology trends of the last decade. During the course of its rapid expansion into various fields of application, many definitions of the Digital Twin emerged, tailored to its respective applications.
Rebecca Richstein, Kai-Uwe Schröder
doaj   +1 more source

Cognitive Digital Twins in the Process Industries

Cognitive Digital Twins aim to enhance Digital Twins by providing a cognition-first approach. To that end, it is essential to understand the types of knowledge that can be realized in the digital domain and their interplay to deliver business value. This
Eirinakis, Pavlos, Kiritsis, Dimitris, Stojanović, Nenad, Lu, Jinzhi, Zheng, Xiaochen, Kalaboukas, Kostas, Rožanec, Jože Martin, Arampatzis, George   +7 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Digital twins for conservation - Digital twin strategy

, 2023
The digital documentation process that was addressed for the knowledge, conservation and management of Pier Luigi Nervi’s Turin Exhibition Center reflected the complexity of the object and required an immense effort to develop a novel, holistic approach, tailored to the strong, interdisciplinary nature of the research.
Giacomo Patrucco, Stefano Perri, Giulia Sammartano, Antonia Spano'   +3 more
openaire   +1 more source

Digital Twins for Process Industries

Publisher Copyright: © 2024 selection and editorial matter, Zhihan Lyu; individual chapters, the contributors.The term process industry is used to refer to a broad range of applications involving the storage and transportation of processing of liquids or
Sierla, Seppo
core   +1 more source