Results 61 to 70 of about 128,358 (272)

Improving cloud storage and privacy security for digital twin based medical records

Journal of Cloud Computing: Advances, Systems and Applications, 2023
As digital transformation progresses across industries, digital twins have emerged as an important technology. In healthcare, digital twins are created by digitizing patient parameters, medical records, and treatment plans to enable personalized care ...
Haibo Yi
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Digital twins of the Earth with and for humans

Communications Earth & Environment
Digital twins of the Earth are digital representations of the Earth system, spanning scales and domains. Their purpose is to monitor, forecast and assess the Earth system and the consequences of human interventions on the Earth system.
W. Hazeleger, J. P. M. Aerts, P. Bauer, M. F. P. Bierkens, G. Camps-Valls, M. M. Dekker, F. J. Doblas-Reyes, V. Eyring, C. Finkenauer, A. Grundner, S. Hachinger, D. M. Hall, T. Hartmann, F. Iglesias-Suarez, M. Janssens, E. R. Jones, T. Kölling, M. Lees, S. Lhermitte, R. V. van Nieuwpoort, A.-K. Pahker, O. J. Pellicer-Valero, F. P. Pijpers, A. Siibak, J. Spitzer, B. Stevens, V. V. Vasconcelos, F. C. Vossepoel   +27 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A generic framework for qualifications of digital twins in maintenance

Journal of Automation and Intelligence, 2023
Digital twins have emerged as a promising technology for maintenance applications, enabling organizations to simulate and monitor physical assets to improve their performance. In Operation and Maintenance (O&M), digital twin facilitates the diagnosis and
Jie Liu, Xingheng Liu, Jørn Vatn, Shen Yin   +3 more
doaj   +1 more source

DIGITAL TWINS: Video demonstration (digital twin)

, 2017
DIGITAL TWINS. Project funded by the Valencian Institute of Business Competitiveness (IVACE) and European Union through the European Regional Development Fund (ERDF), within the public grant program adressed to Technological Institutes of the Valencian Community for the development of non-economic R&D projects carried out in cooperation with ...
openaire   +1 more source

Digital twins for conservation - Digital twin strategy

, 2023
The digital documentation process that was addressed for the knowledge, conservation and management of Pier Luigi Nervi’s Turin Exhibition Center reflected the complexity of the object and required an immense effort to develop a novel, holistic approach, tailored to the strong, interdisciplinary nature of the research.
Giacomo Patrucco, Stefano Perri, Giulia Sammartano, Antonia Spano'   +3 more
openaire   +1 more source

How Digital Twin Concept Supports Internal Transport Systems?—Literature Review

Energies, 2021
In the Industry 4.0 era, the Digital Twin has become one of the most promising enabling technologies supporting material flow. Although the literature on the Digital Twin is becoming relatively well explored, including a certain number of review papers ...
Monika Kosacka-Olejnik, Mariusz Kostrzewski, Magdalena Marczewska, Bogna Mrówczyńska, Paweł Pawlewski   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

New measurements of total ionizing dose in the lunar environment [PDF]

, 2011
[1] We report new measurements of solar minimum ionizing radiation dose at the Moon onboard the Lunar Reconnaissance Orbiter (LRO) from June 2009 through May 2010.
Blake, J. B., Case, A. W., Crain, W. R., Golightly, M. J., Kasper, J. C., Looper, M. D., Mabry, D. J., Mazur, J. E., Spence, Harlan E.   +8 more
core   +3 more sources