Results 61 to 70 of about 37,303,817 (298)

The Economics of Digital Twins [PDF]

Computer, 2021
Digital twins provide a number of economic, health, social, and environmental benefits. Their value can be amplified by combining them with other technologies and tools.
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Digital Twins for Wastewater Treatment: A Technical Review

Engineering
The digital twins concept enhances modeling and simulation through the integration of real-time data and feedback. This review elucidates the foundational elements of digital twins, covering their concept, entities, domains, and key technologies.
Ai-Jie Wang, Hewen Li, Zhejun He, Yu Tao, Hongcheng Wang, Min Yang, Dragan Savic, Glen T. Daigger, Nanqi Ren   +8 more
doaj   +1 more source

Using digital twins to manage traffic flows [PDF]

E3S Web of Conferences
This paper explores the use of digital twins for traffic flows. Explores how digital twins can be applied to effectively manage traffic flows, including improving road safety, optimizing vehicle flow, and improving overall transportation system ...
Shamlitsky Yaroslav, Aleksey Ovsyankin, Morozov Evgeny, Strekaleva Tatiana   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Digital twins of the Earth with and for humans

Communications Earth & Environment
Digital twins of the Earth are digital representations of the Earth system, spanning scales and domains. Their purpose is to monitor, forecast and assess the Earth system and the consequences of human interventions on the Earth system.
W. Hazeleger, J. P. M. Aerts, P. Bauer, M. F. P. Bierkens, G. Camps-Valls, M. M. Dekker, F. J. Doblas-Reyes, V. Eyring, C. Finkenauer, A. Grundner, S. Hachinger, D. M. Hall, T. Hartmann, F. Iglesias-Suarez, M. Janssens, E. R. Jones, T. Kölling, M. Lees, S. Lhermitte, R. V. van Nieuwpoort, A.-K. Pahker, O. J. Pellicer-Valero, F. P. Pijpers, A. Siibak, J. Spitzer, B. Stevens, V. V. Vasconcelos, F. C. Vossepoel   +27 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The crane radar: Development and deployment of an operational eco-digital twin

Ecological Informatics
As virtual copies of real-world phenomena, digital twins are rapidly gaining popularity in industry, academia and policy. Their main strength is informing decision makers in an operational environment by giving detailed up-to-date information about the ...
K. De Koning
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source