Results 71 to 80 of about 128,358 (272)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Digital Twin

, 2023
Denne masteroppgaven har som mål å bidra til å utvikle en Digital Tvilling som i samarbeid med industrielle samarbeidspartnere er på vei. Oppgaven produserer pålitelige eksperimentelle caser som lager et solid fundament for framtidig bruk i en Digital Tvilling.
Ranjan Ganguli, Sondipon Adhikari, Souvik Chakraborty, Mrittika Ganguli   +3 more
openaire   +3 more sources

The crane radar: Development and deployment of an operational eco-digital twin

Ecological Informatics
As virtual copies of real-world phenomena, digital twins are rapidly gaining popularity in industry, academia and policy. Their main strength is informing decision makers in an operational environment by giving detailed up-to-date information about the ...
K. De Koning
doaj   +1 more source

A New Concept of Digital Twin Supporting Optimization and Resilience of Factories of the Future

Applied Sciences, 2020
In the context of Industry 4.0, a growing use is being made of simulation-based decision-support tools commonly named Digital Twins. Digital Twins are replicas of the physical manufacturing assets, providing means for the monitoring and control of ...
Adrien Bécue, Eva Maia, Linda Feeken, Philipp Borchers, Isabel Praça   +4 more
doaj   +1 more source

Detecting outliers and learning complex structures with large spectroscopic surveys - a case study with APOGEE stars

, 2018
In this work we apply and expand on a recently introduced outlier detection algorithm that is based on an unsupervised random forest. We use the algorithm to calculate a similarity measure for stellar spectra from the Apache Point Observatory Galactic ...
Baron, Dalya, Poznanski, Dovi, Reis, Itamar, Shahaf, Sahar, Zasowski, Gail   +4 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Characterizing the Digital Twin in Structural Mechanics

Designs
The Digital Twin is one of the major technology trends of the last decade. During the course of its rapid expansion into various fields of application, many definitions of the Digital Twin emerged, tailored to its respective applications.
Rebecca Richstein, Kai-Uwe Schröder
doaj   +1 more source

Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest. [PDF]

, 2016
Leg muscle mass and strength are decreased during reduced activity and non-weight-bearing conditions such as bed rest (BR) and spaceflight. Supine treadmill exercise within lower body negative pressure (LBNPEX) provides full-body weight loading during BR
Feiveson, Alan H, Hargens, Alan R, Lee, Stuart MC, Macias, Brandon R, Schneider, Suzanne M, Watenpaugh, Donald E   +5 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels. [PDF]

, 2018
While it is clear that behavioral experience modulates epigenetic profiles, it is less evident how the nature of that experience influences outcomes and whether epigenetic/genetic biomarkers could be extracted to classify different types of behavioral ...
Cory-Slechta, Deborah A., Schneider, Jay S., Singh, Garima, Sobolewski, Marissa   +3 more
core   +2 more sources