Results 71 to 80 of about 37,303,817 (298)

Characterizing the Digital Twin in Structural Mechanics

Designs
The Digital Twin is one of the major technology trends of the last decade. During the course of its rapid expansion into various fields of application, many definitions of the Digital Twin emerged, tailored to its respective applications.
Rebecca Richstein, Kai-Uwe Schröder
doaj   +1 more source

Digital twins for conservation - Digital twin strategy

, 2023
The digital documentation process that was addressed for the knowledge, conservation and management of Pier Luigi Nervi’s Turin Exhibition Center reflected the complexity of the object and required an immense effort to develop a novel, holistic approach, tailored to the strong, interdisciplinary nature of the research.
Giacomo Patrucco, Stefano Perri, Giulia Sammartano, Antonia Spano'   +3 more
openaire   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Digital Twins for Biofluids

Annual Review of Biomedical Engineering
Digital twins—virtual representations dynamically linked to physical systems—have the potential to transform biomedical engineering by enabling real-time prediction, optimization, and personalization in health and disease. In biofluids, digital twins offer a framework for integrating physics-based models with data from clinical imaging, sensors, and ...
C Alberto, Figueroa, Krishna, Garikipati, Haizhou, Yang, Jesse, Capecelatro   +3 more
openaire   +2 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Towards integrated data control for digital twins in industry 4.0

, 2022
The Digital Twin is currently a widely discussed topic for presenting and exchanging information on physical assets through virtual networks. Especially the digitisation of the manufacturing industry, Industry 4.0, drives the implementation of Digital ...
Bader, Sebastian R., Maleshkova, Maria
core   +1 more source

Cognitive Digital Twins in the Process Industries

Cognitive Digital Twins aim to enhance Digital Twins by providing a cognition-first approach. To that end, it is essential to understand the types of knowledge that can be realized in the digital domain and their interplay to deliver business value. This
Eirinakis, Pavlos, Kiritsis, Dimitris, Stojanović, Nenad, Lu, Jinzhi, Zheng, Xiaochen, Kalaboukas, Kostas, Rožanec, Jože Martin, Arampatzis, George   +7 more
core   +1 more source

Digital Twins for Process Industries [PDF]

Publisher Copyright: © 2024 selection and editorial matter, Zhihan Lyu; individual chapters, the contributors.The term process industry is used to refer to a broad range of applications involving the storage and transportation of processing of liquids or
Sierla, Seppo
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source