Results 41 to 50 of about 40,047,387 (232)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Longitudinal Effects of a Digital Weight Management Program on Weight Loss: A Randomized Controlled Trial

Obesity Science & Practice
Objective Digital weight management (WM) programs have emerged as a novel solution for facilitating successful weight loss. However, there is a lack of long‐term, rigorous evaluations of digital WM programs, and there is high variability in weight loss ...
Meaghan McCallum, Robert G. Moulder, Sydney Earl, Kelly Blessing, Paige Thompson, M. Cole Ainsworth, Matt Baldwin, Christine N. May   +7 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study

Obesities
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were originally developed in the late 1980s as a class of antidiabetic medication. However, research over the past decade has found them to be a safe and effective weight-loss agent, which has led to ...
Louis Talay, Matt Vickers
doaj   +1 more source

FEASIBILITY OF A CAMPAIGN INTERVENTION COMPARED TO A STANDARD BEHAVIORAL WEIGHT LOSS INTERVENTION IN OVERWEIGHT AND OBESE ADULTS [PDF]

, 2013
Overweight and obesity are a significant public health concern. Behavioral treatment is considered the first line of intervention for individuals attempting to lose weight.
Garcia, David
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Why People with Overweight and Obesity Are Seeking Care Through Digital Obesity Services: A Qualitative Analysis of Patients from Australia’s Largest Digital Obesity Provider

Telemedicine Reports
Background: Increasingly large numbers of people with overweight and obesity (PWOO) are seeking care through digital services. Digital weight-loss service (DWLS) advocates claim that this is due to the modality’s mitigation of obesity care access ...
Louis Talay, Matt Vickers, Sarah Loftus
doaj   +1 more source

A quasi-experimental study on adult weight loss using a multidimensional approach among a rural population

SAGE Open Medicine, 2023
Objectives: The study aimed to investigate the effectiveness of a yearlong digital multidimensional weight-loss intervention among residents in a southern rural community.
Chelsea Burrell
doaj   +1 more source

Words matter: a qualitative investigation of which weight status terms are acceptable and motivate weight loss when used by health professionals [PDF]

, 2011
<p><b>Background:</b> Obesity prevalence is increasing, which is a major public health concern due to increased risks of associated morbidity.
Benzeval, Michaela, Michaela Benzeval, Gray, Cindy M., Lorimer Karen, Karen Lorimer, Anderson Annie S, Hunt, K., Sally Wyke, Annie S Anderson, Gray Cindy M, Wyke, S., Hunt Kate, Anderson, Annie S, Wyke Sally, Anderson, A.S., Lorimer, Karen, Cindy M Gray, Gray, C.M., Hunt, Kate, Anderson, Annie S., Benzeval, M., Gray, Cindy M, Wyke, Sally, Benzeval Michaela, Lorimer, K., Anderson, Annie S.; id_orcid, Kate Hunt   +26 more
core   +2 more sources