Results 61 to 70 of about 1,096,635 (280)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study

Obesities
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were originally developed in the late 1980s as a class of antidiabetic medication. However, research over the past decade has found them to be a safe and effective weight-loss agent, which has led to ...
Louis Talay, Matt Vickers
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Weight Loss and Engagement in a Tirzepatide-Supported Digital Obesity Program: A Four-Arm Patient-Blinded Retrospective Cohort Study

Telemedicine Reports
Background: Obesity is arguably the greatest public health concern in the present day. Digital weight-loss services (DWLSs) that utilize modern medications have demonstrated potential in increasing access to effective obesity treatment.
Louis Talay, Matt Vickers, Catherine Bell, Tom Galvin   +3 more
doaj   +1 more source

Impact of COVID‐19 on a worksite weight loss program for employees with overweight and obesity

Obesity Science & Practice, 2023
Objective The COVID‐19 pandemic has been shown to be negatively associated with physical activity engagement, adherence to healthy diet, and weight management among people with obesity.
Che Young Lee, Michael C. Robertson, Kendahl Servino, Thuan Le, Margaret Raber, Katherine Oestman, Karen M. Basen‐Engquist   +6 more
doaj   +1 more source

CIA-Net: Robust Nuclei Instance Segmentation with Contour-aware Information Aggregation

, 2019
Accurate segmenting nuclei instances is a crucial step in computer-aided image analysis to extract rich features for cellular estimation and following diagnosis as well as treatment. While it still remains challenging because the wide existence of nuclei
AE Carpenter, C Jung, H Chen, H Oda, J Cheng, J Friedman, J Schindelin, L Pantanowitz, M Veta, N Kumar, O Ronneberger, Q Dou   +11 more
core   +1 more source

Injuries in the Chinese Arena Football League: American Versus Chinese Players. [PDF]

, 2018
Background: Arena football is an indoor version of American football played in indoor arenas on a smaller field with 8 players per team. Only 1 study has evaluated injury rates in arena football, and no study had compared 2 distinct cohorts of players ...
Chen, Shiyi, Chen, Tianwu, Feldman, Michael, Gillespie, Gunnar, Rubenstein, David, Singer, Scott, Wetzler, Austin, Wetzler, Merrick   +7 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Why People with Overweight and Obesity Are Seeking Care Through Digital Obesity Services: A Qualitative Analysis of Patients from Australia’s Largest Digital Obesity Provider

Telemedicine Reports
Background: Increasingly large numbers of people with overweight and obesity (PWOO) are seeking care through digital services. Digital weight-loss service (DWLS) advocates claim that this is due to the modality’s mitigation of obesity care access ...
Louis Talay, Matt Vickers, Sarah Loftus
doaj   +1 more source

Dynamic weight parameter for the Random Early Detection (RED) in TCP networks [PDF]

, 2012
This paper presents the Weighted Random Early Detection (WTRED) strategy for congestion handling in TCP networks. WTRED provides an adjustable weight parameter to increase the sensitivity of the average queue size in RED gateways to the changes in the ...
Cole, P., Dixon, M., Hamadneh, N., Murray, D.   +3 more
core   +1 more source