Results 81 to 90 of about 117,772 (261)

Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]

, 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, García Domínguez, Irene, López Lázaro, Miguel, Maldonado Navas, Dolores, Orta Vázquez, Manuel Luis   +5 more
core   +3 more sources

Monoclonal antibodies that distinguish between two related digitalis glycosides, ouabain and digoxin.

Journal of Immunology, 1999
The exogenous digitalis glycosides, ouabain and digoxin, have been widely used in humans to treat congestive heart failure and cardiac arrhythmias. Several reports have also pointed to the existence of endogenous ouabain- and digoxin-like compounds, but ...
B. Parhami-Seren, C. Bell, M. N. Margolies, G. T. Haupert   +3 more
semanticscholar   +1 more source

Catheter‐based ablation to improve outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction: Rationale and design of the CABA‐HFPEF‐DZHK27 trial

European Journal of Heart Failure, Volume 26, Issue 10, Page 2203-2212, October 2024.
Abstract Aims Atrial fibrillation (AF) is common in heart failure (HF) and negatively impacts outcomes. The role of ablation‐based rhythm control in patients with AF and HF with preserved (HFpEF) or mildly reduced ejection fraction (HFmrEF) is not known.
Abdul S. Parwani, Stefan Kääb, Tim Friede, Roland Richard Tilz, Johann Bauersachs, Norbert Frey, Gerhard Hindricks, Thorsten Lewalter, Michiel Rienstra, Andreas Rillig, Daniel Scherr, Daniel Steven, Paulus Kirchhof, Burkert Pieske   +13 more
wiley   +1 more source

Evaluation of chromosome abberations induced by digoxin in Chinese hamster ovary cells [PDF]

, 2013
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells.
Saadat, Iraj, Saadat, Mostafa, Sedigh-Ardekani, Mozhgan   +2 more
core  

Efficacy and safety of low‐dose digoxin in patients with heart failure. Rationale and design of the DECISION trial

European Journal of Heart Failure, Volume 26, Issue 10, Page 2223-2230, October 2024.
Rationale and design of the DECISION trial. ECG, electrocardiogram; HF, heart failure; LVEF, left ventricular ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association. Abstract Aims Digoxin is the oldest drug in cardiovascular (CV) medicine, and one trial conducted >25 years ago showed a reduction in ...
Dirk J. van Veldhuisen, Michiel Rienstra, Arend Mosterd, A. Marco Alings, Antoinette D.J. van Asselt, Marcel L Bouvy, Jan G.P. Tijssen, Jeroen Schaap, Ernst E. van der Wall, Adriaan A. Voors, Eva M. Boorsma, Dirk J.A. Lok, Harry J.G.M. Crijns, Astrid Schut, Marlene A.T. Vijver, Geert H.D. Voordes, Agaath H. de Vos, Ester L. Maas‐Soer, Nicoline W. Smit, Daan J. Touw, Michelle Samuel, Peter van der Meer, DECISION Investigators and Committees, Dirk J. van Veldhuisen, Peter van der Meer, Michiel Rienstra, Arend Mosterd, Marco Alings, Jan Tijssen, Thea van Asselt, Marcel Bouvy, Ernst E. van der Wall, Jeroen Schaap, Adriaan A. Voors, Harry J. G. M. Crijns, Carlo Gaillard, Nick Veeger   +36 more
wiley   +1 more source

Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na. [PDF]

, 1987
Reduction of the transsarcolemmal [Na] gradient in rabbit cardiac muscle leads to an increase in the force of contraction. This has frequently been attributed to alteration of Ca movements via the sarcolemmal Na/Ca exchange system.
Bers, DM
core  

Clinical Use of Digitalis Glycosides

Cardiology, 1985
Digitalis glycosides continue to place high on the list of prescribed drugs. Digoxin is 8th on prescriptions written in the United States in 1980, digitoxin 16th, and digitalis leaf 23rd. There is little doubt that most physicians continue to believe these drugs are useful.
openaire   +3 more sources

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Determination of the minimal inhibitory concentration of Geneticin G418 in the process of callus Digitalis purpurea L.

Biotecnología Vegetal, 2008
Digitalis purpurea L. produces cardiatonic glycosides such as digoxin and digitoxin, which are widely used for congestive heart failure. Genomic studies in this specie are limited because there is not an efficient genetic transformation system.
Borys Chong-Pérez, Naivy Pérez-Alonso, Zenaida Occeguera Águila, Alina Capote, Anabel Pérez, Elio Jiménez   +5 more
doaj  

The Chemical Estimation of Digitalis and Strophanthus Glycosides

Journal of Pharmacy and Pharmacology, 1949
Abstract Certain glycosides of plant origin possess valuable cardiotonic properties. The Families Scrophulariaceae and Apocynaceae are the plant orders which contain most members furnishing drugs of therapeutic value. If in this connection the toad poisons are included, the heart-active substances from a chemical viewpoint may be ...
openaire   +3 more sources