Results 61 to 70 of about 5,715 (204)

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta [PDF]

, 2013
Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the
Balskus, Emily Patricia, Chatman, Kelly, Gootenberg, David Benjamin, Haiser, Henry J., Sirasani, Gopal, Turnbaugh, Peter   +5 more
core   +1 more source

Production of cadiotonic glycosides in Digitalis purpurea using temporary immersion systems

Biotecnología Vegetal, 2005
Digitalis purpurea, is an example of cardiotonic drug. Digoxin and digitoxin are glycosides produced by this plant which are cardiac stimulants with a wide use in the treatment of heart problems.
Naivy Pérez-Alonso, Elio Jiménez, Dirk Wilken, André Gerth, Annett Jähn, Horst-Michael Nitzsche, Gerhard Kerns   +6 more
doaj  

Catheter Ablation Is Associated With a Decrease in Major Adverse Cardiovascular Events and All‐Cause Mortality in Patients With Atrial Fibrillation and Obstructive Sleep Apnea

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 1, Page 36-45, January 2026.
ABSTRACT Introduction Obstructive sleep apnea (OSA) is a common risk factor for the development and progression of atrial fibrillation (AF). Whether catheter ablation for AF management in patients with coexisting OSA yields survival benefit remains unclear.
Ghassan Bidaoui, Christian Massad, Joe Abi‐Rached, Ahmed Abdelmaksoud, Eman Toraih, Michel Abou‐Khalil, Mayana Bsoul, Montaser Atasi, Amitabh Pandey, Nassir Marrouche, and other members of the TRIAD Team, Yara Menassa, Han Feng, Swati Rao, Chanho Lim, Ala' Assaf, Hadi Younes   +16 more
wiley   +1 more source

Cardenolides metabolism and genetic transformation of Digitalis. Potentialities and challenges

Biotecnología Vegetal, 2010
Cardenolides are secondary metabolites produced by plants of the genus Digitalis. These are widely used in treatments of congestive heart failure. Failed attempts to obtain suitable cardenolide levels from in vitro culture of Digitalis plants have ...
Yovanny Izquierdo, Naivy Pérez-Alonso, Elio Jiménez   +2 more
doaj  

Evaluation of chromosome abberations induced by digoxin in Chinese hamster ovary cells [PDF]

, 2013
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells.
Saadat, Iraj, Saadat, Mostafa, Sedigh-Ardekani, Mozhgan   +2 more
core  

Colored floaters as a manifestation of digoxin toxicity

American Journal of Ophthalmology Case Reports, 2018
Purpose: Since its report in one patient more than 70 years ago, digitalis-induced colored muscae volitantes have not surfaced again in the literature. We report here a case of digoxin induced colored floaters. Observations: An 89-year-old man on 0.25 mg
Lynn Shi, Linus D. Sun, Jeffrey G. Odel
doaj   +1 more source

Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]

, 2019
The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF, Allen, LA, Francis, GS, Gottlieb, SS, Lancellotti, P, Psotka, MA, Rosano, GMC, Teerlink, JR   +7 more
core   +2 more sources

Exploring the Cancer Therapeutic Potential of Traditional Medicinal Plants by Modulating the Apoptotic Pathway

BioMed Research International, Volume 2026, Issue 1, 2026.
Introduction Cancer is a versatile disease with a high rate of relapse and mortality. Despite the presence of various treatment modalities, there is a serious need for the development of its management. Phytochemicals, which are abundant in nature, can be turned into novel medications for these types of diseases by optimizing their functions and ...
Mithila Kulkarni, Mohammad Amjad Hussain, Reginald Samson Valdar, Shreya Hebbar, Suparna Laha, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Growth and Photosynthetic Characteristics of Two Strawberry Cultivars in Response to Furostanol Glycosides Treatments

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2013
Furostanol glycosides represent a large group of steroid compounds of plant origin with a broad spectrum of biological activities (anabolic, antioxidant, anti-fungal and nematicidal).
Raluca Petronela CĂULEŢ, Aliona MORARIU, Dorina IUREA, Gică GRĂDINARIU   +3 more
doaj   +1 more source

Contemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM‐HF registry

European Journal of Heart Failure, Volume 27, Issue 12, Page 2691-2704, December 2025.
Medical therapy use across the left ventricular ejection fraction spectrum in the OPTIPHARM‐HF registry. ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin II receptor blocker; ARNI, angiotensin receptor–neprilysin inhibitor; GDMT, guideline‐directed medical therapy; HF, heart failure; HFmrEF, heart failure with mildly reduced ejection ...
Riccardo M. Inciardi, Maurizio Volterrani, Gianluigi Savarese, Muthiah Vaduganathan, Chiara Oriecuia, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Giuseppe Armentaro, Chiara Arzilli, Nadia Aspromonte, Andrea Attanasio, Roberto Badagliacca, Lucia Barbieri, Pier Paolo Bocchino, Francesca Bursi, Matteo Cameli, Martino Canonero, Jeness S. Campodonico, Teresa Capovilla, Erberto Carluccio, Stefano Carugo, Vincenzo Castiglione, Dario Catapano, Manlio Cipriani, Michele Correale, Domenico D'Amario, Raffaele De Caterina, Gaetano M. De Ferrari, Emilia D'Elia, Luca Di Odoardo, Michele Emdin, Luigi Falco, Giulia Ferrante, Alessandra Fornaro, Paolo Fornaro, Gionata Guastamiglio, Marco Guazzi, Massimo Iacoviello, Massimo Imazio, Enrico Incaminato, Maria Teresa La Rovere, Sergio Leonardi, Marta Maccallini, Giulia E. Mandoli, Daniele Masarone, Marco Masetti, Alberto Mazzoni, Marta Mazzotta, Marco Merlo, Luigi Moschini, Filippo Novarese, Alberto Palazzuoli, Maria C. Pastore, Giuseppe Patti, Roberto F.E. Pedretti, Stefano Pidello, Massimo F. Piepoli, Giuseppe Pinto, Luciano Potena, Claudia Raineri, Filippo M. Rubbo, Mario Sabatino, Andrea Salzano, Angela Sciacqua, Michele Senni, Paolo Severino, Gianfranco Sinagra, Barbara Sposato, Stefano Taddei, Alessandro Valleggi, Carlo Vignati, Dario Vizza, Claudia Specchia, Giuseppe Rosano, Marco Metra, on behalf of the OPTIPHARM‐HF investigators, Marianna Adamo, Marilisa Ambrosio, Paolo Biagioli, Valeria Borelli, Natale Brunetti, Margherita Calcagnino, Giuseppe Caminiti, Francesco Canonico, Angelo Caporotondi, Velia Cassano, Ali Chraim, Valentina Codazzi, Giuliana Cimino, Francesco Clemenza, Giuditta Cuccuru, Giulia De Lio, Giandomenico Disabato, Marcello Divino, Salvatore D'Isa, Roberta Famiani, Enrica Fede, Letizia Fiòorentino, Alberto Foa', Paolo Fornaro, Noemi Furlotti, Nicolò Gallingani, Alberto Genova, Stefano Ghio, Federico Gobbi, Daniela Grassano, Lucia Guerisoli, Manuela Iseppi, Simona Leone, Ferdinando Loiacono, Valeria Luberto, Rossella Manai, Niccolò Manetti, Lina Manzi, Fabio Marsico, Francesco Maruca, Gabriele Masini, Irene Mattavelli, Ciro Mauro, Alberto Mazzoni, Marta Mazzotta, Pierre Meynet, Valentina Morsella, Giulia Nemola, Martina Niccolai, Savina Nodari, Matteo Pagnesi, Gianpaolo Palmieri, Alberto Panza, Francesca Parisi, Carlo Alberto Pastura, Anna Lisa Picerni, Riccardo Pilia, Ilaria Pirrone, Nicola R. Pugliese, Claudio Puteo, Federica Ramani, Gloria Santangelo, Laura Scelsi, Edoardo Sciatti, Lorenza Sforzini, Giulia Spoto, Davide Stolfo, Roberto Tarantini, Maria Cristina Tavera, Floriana Tortomasi, Eduardo Valente, Giuseppe Varricchione, Enrico Vizzardi, Greta Zagni, Mattia Zampieri   +152 more
wiley   +1 more source