Results 81 to 90 of about 102,393 (385)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Cloud technologies as a means of open education

open access: yesCTE Workshop Proceedings, 2013
The development of modern society is acquiring more pronounced signs of internationality, globalization, competitiveness, causing the need for comprehensive modernization of virtually all branches of human life: production, science, education, life, etc.
Yu. H. Zaporozhchenko
doaj   +1 more source

The Birth of Pictoriality in Computer Media [PDF]

open access: yes, 2016
The aim of the paper is to follow some milestones of the story of computer media as far as the notion of pictoriality is concerned. I am going to describe in the most general way how it happens that two quite separate technologies as computer machine ...
Gajewski, Krzysztof
core  

Digitalisation and environmental management activities: The effects of family ownership`

open access: yesBusiness Strategy and the Environment
While digitalisation has significant implications for environmental management activities, this nexus has received minimal attention in research. Given this backdrop, this study uses a unique survey dataset of 386 micro and small enterprises (MSEs) and ...
W. Issah   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Electronic grade book as tool for monitoring the level of students’ physics research competencies

open access: yesCTE Workshop Proceedings, 2014
The purpose of this study is to describe the methods of monitoring the level of students’ physics research competencies. The main task is to show the possibilities of electronic grade book using for determination the level of students’ physics research ...
O. V. Merzlykin
doaj   +1 more source

Reflections on the EU objectives in addressing aggressive tax planning and harmful tax practices Final Report. CEPS Report November 2019 [PDF]

open access: yes, 2019
This Report analyses the EU’s instruments to tackle aggressive tax planning and harmful tax practices. Based on desk research, interviews with stakeholders and expert assessments, it considers the coherence, relevance, and added value of the EU’s ...
Campmas, Alexandra   +4 more
core  

Do Cyber security, Digitalisation and Data Visualisation Affect the Quality of Internal Environmental Audits?

open access: yesAustralasian Business, Accounting and Finance Journal
Introduction/Main Objectives: This research was conducted to provide empirical evidence regarding the analysis of the influence of cyber security, digitalisation, and data visualisation on the quality of internal environmental audits. Background Problems:
K. Saputra, Selmita Paranoan
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Effects of a Multifunctional Cover Crop (LivinGro®) on Soil Quality Indicators in Zaragoza, Spain

open access: yesLand
Soil degradation is a significant threat to agricultural systems and contemporary societies worldwide, especially in the context of climate change.
Javier González-Pérez   +5 more
doaj   +1 more source

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