Results 111 to 120 of about 3,700,434 (389)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

spotlight no. 5, 2018 - #SmartHealthSystems Digitalization requires an effective strategy, compelling political leadership and a coordinating institution with a national mandate [PDF]

, 2018
In terms of digitalizing its healthcare sector, Germany trails far behind several other countries as the potential for quality and efficiency in German healthcare remains untapped ●● Countries that are succeeding in digitalizing their healthcare systems ...
Kostera, Thomas, Thranberend, Timo
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The transformation of traditional banking activity in digital [PDF]

, 2019
Purpose: This article investigates specifics of the transformation of banking activity in the conditions of digitalization of the economy. In the light of penetration of digital technologies into all the spheres of our life, the rapid development of ...
Galazova, S. S., Magomaeva, L. R.
core  

The critical role of innovation for the well-being of our society: a multilateral approach matters [PDF]

, 2018
The article analyzes the importance of innovation in promoting social well-being and its possible role in driving prosperity and accelerating regional development. It elaborates on the paramount role of small and mediium sized enterprises in generating
Billi, Andrea, PFEIFFER, CHRISTIN
core   +1 more source

On Digital History

BMGN - Low Countries Historical Review, 2013
Digital humanities seem to be omnipresent these days and the discipline of history is no exception. This introduction is concerned with the changing practice of ‘doing’ history in the digital age, seen within a broader historical context of developments in the digital humanities and ‘digital history’.
openaire   +8 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Digital humanities, digital methods, digital history, and digital outputs: History writing and the digital revolution [PDF]

History Compass, 2018
AbstractWhile the term “digital humanities” appears inclusive, its exact meaning remains unclear and its early association with studies in English Literature means the term has already been partially superceded by “digital methods.” However, that renaming is problematic as it emphasises the research tools used while the field itself is adjusting to ...
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Design of an Efficient Interconnection Network of Temperature Sensors [PDF]

, 2010
Temperature has become a first class design constraint because high temperatures adversely affect circuit reliability, static power and degrade the performance. In this scenario, thermal characterization of ICs and on-chip temperature monitoring represent
Gomez Osuna, Carlos, Ituero Herrero, Pablo, López Vallejo, Marisa, Sánchez Marcos, Miguel Ángel   +3 more
core   +1 more source