Results 11 to 20 of about 10,909 (272)

Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma [PDF]

Advanced Science
RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their potential role
Cunjie Chang, Lina Li, Ling Su, Fan Yang, Quanxiu Zha, Mengqing Sun, Lin Tao, Menglan Wang, Kangli Song, Liangyu Jiang, Haojin Gao, Yexin Liang, Chao Xu, Caiyu Yong, Minmin Wang, Jiacheng Huang, Jing Liu, Weiwei Jin, Wenyuan Lv, Heng Dong, Qian Li, Fangtian Bu, Shuanghong Yan, Haoxiang Qi, Shujuan Zhao, Yingshuang Zhu, Yu Wang, Junping Shi, Yiting Qiao, Jian Xu, Benoit Chabot, Jianxiang Chen   +31 more
doaj   +3 more sources

DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure (DIGIT-HF): Baseline characteristics compared to recent randomized controlled heart failure trials. [PDF]

Eur J Heart Fail
Effects of digitoxin compared to placebo on efficacy and safety in patients with heart failure and reduced ejection fraction (HFrEF). Primary endpoint: time to all‐cause death and first hospitalization for worsening heart failure (whatever occurs first). ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin
Bavendiek U, Thomas NH, Berliner D, Liu X, Schwab J, Rieth A, Maier LS, Schallhorn S, Angelini E, Soltani S, Rathje F, Sandu MA, Geller W, Gaspar T, Hambrecht R, Zdravkovic M, Philipp S, Kosevic D, Nickenig G, Scheiber D, Winkler S, Becher PM, Lurz P, Hülsmann M, von Karpowitz M, Schröder C, Neuhaus B, Seltmann A, von der Leyen H, Veltmann C, Störk S, Böhm M, Koch A, Großhennig A, Bauersachs J, DIGIT‐HF Study Group.   +35 more
europepmc   +3 more sources

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

Integrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang   +5 more
doaj   +2 more sources

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard   +18 more
doaj   +2 more sources

Digitoxin and its analogs as novel cancer therapeutics

Experimental Hematology & Oncology, 2012
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A, Stueckle Todd A, Tse William, Rojanasakul Yon, Dinu Cerasela   +4 more
doaj   +2 more sources

A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa [PDF]

iScience
Summary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield, Ian A. Dubery, Paul A. Steenkamp   +2 more
doaj   +2 more sources

The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner [PDF]

Basic Research in Cardiology, 2020
Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as \textquotedblpositive adhesiotropy\textquotedbl, was demonstrated to be a function of sympathetic ...
Egu, Desalegn Tadesse, Feinendegen, Manouk, Flaswinkel, Heinrich, Kempf, Ellen, Olivares-Florez, Silvana, Schinner, Camilla, Schlipp, Angela, Trenz, Sebastian, Waschke, Jens, Yeruva, Sunil   +9 more
core   +2 more sources

Report on Digitoxin [PDF]

Journal of AOAC INTERNATIONAL, 1955
Daniel Banes
openaire   +3 more sources

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +2 more sources

Exploring bacterial key genes and therapeutic agents for breast cancer among the Ghanaian female population: Insights from In Silico analyses. [PDF]

PLoS ONE
Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of BC development and progression, and ...
Md Kaderi Kibria, Md Ahad Ali, Md Nurul Haque Mollah   +2 more
doaj   +2 more sources