Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation [PDF]
Molecules, 2016 Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang +11 more
doaj +3 more sources
Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3
Integrative Cancer Therapies, 2021 Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou +5 more
doaj +2 more sources
Short term protective effect of digitoxin in sepsis-induced acute lung injury [PDF]
Biocell (Mendoza), 2022 Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in ...
Bora, Ejder Saylav +6 more
core +2 more sources
The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner [PDF]
Basic Research in Cardiology, 2020 Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as \textquotedblpositive adhesiotropy\textquotedbl, was demonstrated to be a function of sympathetic ...
Egu, Desalegn Tadesse +9 more
core +2 more sources
Frontiers in Oncology, 2019 Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard +18 more
doaj +2 more sources
Digitoxin and its analogs as novel cancer therapeutics
Experimental Hematology & Oncology, 2012 A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A +4 more
doaj +2 more sources
Simultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury. [PDF]
Semin DialABSTRACT Extracorporeal therapies could be required for treatment of life‐threatening severe acute intoxication. We present the case of an 82‐year‐old patient admitted to our Nephrology Unit because of metformin‐associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria).
Zappulo F +7 more
europepmc +2 more sources
Digitoxin metabolism by rat liver microsomes. [PDF]
, 1975 Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs. Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Benthe, H.F. +2 more
core +3 more sources
A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa [PDF]
iScienceSummary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield +2 more
doaj +2 more sources