Results 11 to 20 of about 2,840 (150)

Exploring bacterial key genes and therapeutic agents for breast cancer among the Ghanaian female population: Insights from In Silico analyses. [PDF]

PLoS ONE
Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of BC development and progression, and ...
Md Kaderi Kibria, Md Ahad Ali, Md Nurul Haque Mollah   +2 more
doaj   +2 more sources

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses

Molecules, 2021
Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition.
Jan Škubník, Jiří Bejček, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová   +3 more
doaj   +1 more source

Quo vadis Cardiac Glycoside Research?

Toxins, 2021
Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček, Michal Jurášek, Vojtěch Spiwok, Silvie Rimpelová   +3 more
doaj   +1 more source

Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up. [PDF]

Clin Pharmacol Ther
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Tremmel R, Schreeck F, Jaeger S, Schricker S, Schaeffeler E, Igel S, Steinberger D, Pagitz M, Latus J, Ketteler M, Bühl K, Dahlke MH, Kopp HG, Schwab M.   +13 more
europepmc   +2 more sources

Digitoxin and its analogs as novel cancer therapeutics

Experimental Hematology & Oncology, 2012
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A, Stueckle Todd A, Tse William, Rojanasakul Yon, Dinu Cerasela   +4 more
doaj   +1 more source

The in vivo effect of digitoxin on rat heart phosphatides*

Journal of Lipid Research, 1961
Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin.
G.V. Marinetti, K. Temple, Elmer Stotz
doaj   +1 more source

Na⁺/K⁺-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation

Molecules, 2021
Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček, Vojtěch Spiwok, Eva Kmoníčková, Silvie Rimpelová   +3 more
doaj   +1 more source

Digitoxin medication and cancer; case control and internal dose-response studies

BMC Cancer, 2001
Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer
Spigset Olav, Klepp Olbjørn, Haux Johan, Tretli Steinar   +3 more
doaj   +1 more source

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

Integrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang   +5 more
doaj   +1 more source