Results 11 to 20 of about 10,900 (273)

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation [PDF]

open access: goldMolecules, 2016
Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang   +11 more
doaj   +3 more sources

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

open access: yesIntegrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou   +5 more
doaj   +2 more sources

Short term protective effect of digitoxin in sepsis-induced acute lung injury [PDF]

open access: yesBiocell (Mendoza), 2022
Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in ...
Bora, Ejder Saylav   +6 more
core   +2 more sources

The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner [PDF]

open access: yesBasic Research in Cardiology, 2020
Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as \textquotedblpositive adhesiotropy\textquotedbl, was demonstrated to be a function of sympathetic ...
Egu, Desalegn Tadesse   +9 more
core   +2 more sources

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

open access: yesFrontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard   +18 more
doaj   +2 more sources

Digitoxin and its analogs as novel cancer therapeutics

open access: yesExperimental Hematology & Oncology, 2012
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A   +4 more
doaj   +2 more sources

Simultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury. [PDF]

open access: yesSemin Dial
ABSTRACT Extracorporeal therapies could be required for treatment of life‐threatening severe acute intoxication. We present the case of an 82‐year‐old patient admitted to our Nephrology Unit because of metformin‐associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria).
Zappulo F   +7 more
europepmc   +2 more sources

Digitoxin metabolism by rat liver microsomes. [PDF]

open access: green, 1975
Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs. Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Benthe, H.F.   +2 more
core   +3 more sources

Report on Digitoxin [PDF]

open access: bronzeJournal of AOAC INTERNATIONAL, 1955
Daniel Banes
openaire   +3 more sources

A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa [PDF]

open access: yesiScience
Summary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield   +2 more
doaj   +2 more sources

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