Results 21 to 30 of about 10,900 (273)

DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure (DIGIT‐HF): Baseline characteristics compared to recent randomized controlled heart failure trials

European Journal of Heart Failure, EarlyView.
Effects of digitoxin compared to placebo on efficacy and safety in patients with heart failure and reduced ejection fraction (HFrEF). Primary endpoint: time to all‐cause death and first hospitalization for worsening heart failure (whatever occurs first). ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin
Udo Bavendiek, Nele Henrike Thomas, Dominik Berliner, Xiaofei Liu, Johannes Schwab, Andreas Rieth, Lars S. Maier, Sven Schallhorn, Eleonora Angelini, Samira Soltani, Fabian Rathje, Mircea‐Andrei Sandu, Welf Geller, Thomas Gaspar, Rainer Hambrecht, Marija Zdravkovic, Sebastian Philipp, Dragana Kosevic, Georg Nickenig, Daniel Scheiber, Sebastian Winkler, Peter Moritz Becher, Philipp Lurz, Martin Hülsmann, Maria von Karpowitz, Christoph Schröder, Barbara Neuhaus, Anika Seltmann, Heiko von der Leyen, Christian Veltmann, Stefan Störk, Michael Böhm, Armin Koch, Anika Großhennig, Johann Bauersachs, on behalf of the DIGIT‐HF Study Group   +35 more
wiley   +2 more sources

Digitalis Therapy Is Associated With an Increased Risk of ICD Shock Delivery and Device Revision. [PDF]

Ann Noninvasive Electrocardiol
In the presence of more nonischemic cardiomyopathy and more comorbidities in the digoxin group, digitalis glycosides were associated with an increased risk for rehospitalization or device revision, while no significant differences in mortality or major complications, including stroke or myocardial infarction, were observed.
Frommeyer G, Lange PS, Kleemann T, Stellbrink C, Ince H, Brachmann J, Lewalter T, Hochadel M, Senges J, Eckardt L.   +9 more
europepmc   +2 more sources

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +2 more sources

Ex vivo activity of cardiac glycosides in acute leukaemia. [PDF]

PLoS ONE, 2011
BACKGROUND: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this potential clinically. Reports have demonstrated promising in vitro
Helene Hallböök, Jenny Felth, Anna Eriksson, Mårten Fryknäs, Lars Bohlin, Rolf Larsson, Joachim Gullbo   +6 more
doaj   +5 more sources

Exploring bacterial key genes and therapeutic agents for breast cancer among the Ghanaian female population: Insights from In Silico analyses. [PDF]

PLoS ONE
Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of BC development and progression, and ...
Md Kaderi Kibria, Md Ahad Ali, Md Nurul Haque Mollah   +2 more
doaj   +2 more sources

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein [PDF]

Scientific Reports
SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, ENaC, the ...
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Ognoon Mungunsukh, Qingfeng Yang, Nathan I. Walton, Bette S. Pollard, Sara Khanal, Shannon Hentschel, Catalina Florez, Andrew S. Herbert, Harvey B. Pollard   +11 more
doaj   +2 more sources

Der Nachweis von Digitoxin [PDF]

Fresenius' Zeitschrift für analytische Chemie, 1900
n ...
R. H. Lavermann
openaire   +5 more sources

Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial. [PDF]

Clin Res Cardiol, 2023
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial. In DIGIT-HF, digitoxin
Bavendiek U, Großhennig A, Schwab J, Berliner D, Liu X, Maier L, Gaspar T, Rieth A, Philipp S, Hambrecht R, Westenfeld R, Münzel T, Winkler S, Hülsmann M, Westermann D, Zdravkovic M, Lichtinghagen R, von der Leyen H, Zimmermann S, Veltmann C, Böhm M, Störk S, Koch A, Bauersachs J.   +23 more
europepmc   +2 more sources

Ueber Digitoxin und Digitalin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1898
n ...
H. Kiliani
openaire   +3 more sources

Development of a new ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the determination of digoxin and digitoxin in plasma: Comparison with a clinical immunoassay

Electrophoresis, 2022
Cardiac glycosides digoxin and digitoxin are used in therapy for the treatment of congestive heart failure. Moreover, these compounds can be responsible for intoxication cases caused by fortuitous ingestion of leaves of Digitalis.
Marco Ballotari, Francesco Taus, Giulia Tolle, E. Danese, R. Dorizzi, F. Tagliaro, R. Gottardo   +6 more
semanticscholar   +1 more source