Results 21 to 30 of about 11,104 (231)
Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation [PDF]
Journal of Virology, 2018 Rupkatha Mukhopadhyay +3 more
semanticscholar +2 more sources
International Journal of Molecular Sciences, 2022 Digitoxin has repeatedly shown to have negative effects on cancer cell viability; however, the actual mechanism is still unknown. In this study, we investigated the effects of digitoxin (1–100 nM) in four pancreatic cancer cell lines, BxPC-3, CFPAC-1 ...
H. Lindholm +2 more
semanticscholar +1 more source
Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up. [PDF]
Clin Pharmacol TherOverview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Tremmel R +13 more
europepmc +2 more sources
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Biocell (Mendoza), 2022 Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying ...
Ejder Saylav Bora +6 more
semanticscholar +1 more source
Transforming Growth Factor-β Pathway: Biological Functions and Therapeutic Targets. [PDF]
MedComm (2020)Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Mekky RH +9 more
europepmc +2 more sources
Medicine International, 2022 The alpha subunits (ATP1A1-3) of Na+/K+-ATPase binds digitoxin with varying affinity. The expression levels of these subunits dictate the anticancer effects of digitoxin.
H. Lindholm +2 more
semanticscholar +1 more source
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses
Molecules, 2021 Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition.
Jan Škubník +3 more
doaj +1 more source
Quo vadis Cardiac Glycoside Research?
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
doaj +1 more source
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Molecules, 2021 Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček +3 more
doaj +1 more source