Results 21 to 30 of about 10,909 (272)

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein [PDF]

Scientific Reports
SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, ENaC, the ...
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Ognoon Mungunsukh, Qingfeng Yang, Nathan I. Walton, Bette S. Pollard, Sara Khanal, Shannon Hentschel, Catalina Florez, Andrew S. Herbert, Harvey B. Pollard   +11 more
doaj   +2 more sources

Ueber Digitoxin und Digitalin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1898
n ...
H. Kiliani
openaire   +3 more sources

Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial. [PDF]

Clin Res Cardiol, 2023
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial. In DIGIT-HF, digitoxin
Bavendiek U, Großhennig A, Schwab J, Berliner D, Liu X, Maier L, Gaspar T, Rieth A, Philipp S, Hambrecht R, Westenfeld R, Münzel T, Winkler S, Hülsmann M, Westermann D, Zdravkovic M, Lichtinghagen R, von der Leyen H, Zimmermann S, Veltmann C, Böhm M, Störk S, Koch A, Bauersachs J.   +23 more
europepmc   +2 more sources

The DIGIT-HF trial: Key amendments of study design. [PDF]

Eur J Heart Fail
European Journal of Heart Failure, Volume 27, Issue 3, Page 606-608, March 2025.
Bavendiek U, Berliner D, Thomas NH, Liu X, Schwab J, Rieth A, Maier LS, Schallhorn S, Angelini E, Rathje F, Sandu MA, Geller W, Gaspar T, Hambrecht R, Zdravkovic M, Philipp S, Kosevic D, Nickenig G, Scheiber D, Winkler S, Becher PM, Lurz P, Hülsmann M, Schröder C, Seltmann A, von der Leyen H, Veltmann C, Störk S, Böhm M, Koch A, Bauersachs J.   +30 more
europepmc   +2 more sources

Transforming Growth Factor-β Pathway: Biological Functions and Therapeutic Targets. [PDF]

MedComm (2020)
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Mekky RH, Abo-El Fetoh ME, Faheem SA, Radwan AF, Fawzy MH, Mustafa AM, Said MA, Calina D, Sharifi-Rad J, Cho WC.   +9 more
europepmc   +2 more sources

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

Development of a new ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the determination of digoxin and digitoxin in plasma: Comparison with a clinical immunoassay

Electrophoresis, 2022
Cardiac glycosides digoxin and digitoxin are used in therapy for the treatment of congestive heart failure. Moreover, these compounds can be responsible for intoxication cases caused by fortuitous ingestion of leaves of Digitalis.
Marco Ballotari, Francesco Taus, Giulia Tolle, E. Danese, R. Dorizzi, F. Tagliaro, R. Gottardo   +6 more
semanticscholar   +1 more source

Short term protective effect of digitoxin in sepsis-induced acute lung injury

Biocell (Mendoza), 2022
Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying ...
Ejder Saylav Bora, MüMIN ALPER ERDOĞAN, B. Özkul, İbrahim HALIL SEVER, İ. Söğüt, C. Hürdağ, O. Erbaş   +6 more
semanticscholar   +1 more source

Digitoxin Affects Metabolism, ROS Production and Proliferation in Pancreatic Cancer Cells Differently Depending on the Cell Phenotype

International Journal of Molecular Sciences, 2022
Digitoxin has repeatedly shown to have negative effects on cancer cell viability; however, the actual mechanism is still unknown. In this study, we investigated the effects of digitoxin (1–100 nM) in four pancreatic cancer cell lines, BxPC-3, CFPAC-1 ...
H. Lindholm, K. Ejeskär, Ferenc L. M. Szekeres   +2 more
semanticscholar   +1 more source

Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses

Molecules, 2021
Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition.
Jan Škubník, Jiří Bejček, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová   +3 more
doaj   +1 more source