Results 21 to 30 of about 2,840 (150)

Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors

Digital Chinese Medicine, 2023
Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
doaj   +1 more source

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard   +18 more
doaj   +1 more source

In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations

Molecules, 2022
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed, Rafaela S. Ferreira, José Rogério A. Silva   +2 more
doaj   +1 more source

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

Scientific Reports, 2021
To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I. Walton, Tony T. Wang, Harvey B. Pollard   +8 more
doaj   +1 more source

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Respiratory Research, 2019
Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs.
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard   +9 more
doaj   +1 more source

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

Chemical Composition of Methanolic Extracts of Scutellaria orientalis L.: Digitoxin and Neocurdione Detection by Gas Chromatography/Mass Spectrometry

Pharmaceutical and Biomedical Research, 2022
Background: Scutellaria orientalis subsp. virens is a species of Scutellaria genus (the Lamiaceae family). The aqueous root extract of S. orientalis has been traditionally used by Iranians to treat neurological disorders, dermatitis, and bronchitis.
Zahra Gharari, Khadijeh Bagheri, Ali Sharafi   +2 more
doaj  

Estimulación de cardenólidos en brotes de Digitalis purpurea L. cultivados in vitro mediante elicitores

Revista Colombiana de Biotecnología, 2014
Digitalis purpurea L. es una de las principales fuentes de cardenólidos tales como digoxina y digitoxina. Estos fármacos son ampliamente usados en la disfunción cardíaca y para regular las arritmias del corazón.
Naivy Lisbet Pérez-Alonso, Franklyn Arana Labrada, Alina Capote Pérez, Anabel Pérez Pérez, Rafael Sosa, Angel Mollineda, Elio Jiménez González   +6 more
doaj   +1 more source

Ex vivo activity of cardiac glycosides in acute leukaemia. [PDF]

PLoS ONE, 2011
BACKGROUND: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this potential clinically. Reports have demonstrated promising in vitro
Helene Hallböök, Jenny Felth, Anna Eriksson, Mårten Fryknäs, Lars Bohlin, Rolf Larsson, Joachim Gullbo   +6 more
doaj   +1 more source

Drug Repurposing Against SARS-CoV-2: Targeting NSP16-NSP10 Interaction

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
Drug repurposing studies played an important role for fighting with the Covid-19 pandemic. Discovering a new drug molecule for a disease takes a very long time. However, repurposing a drug molecule developed for another disease can accelerate to find new
Sefer BADAY
doaj   +1 more source