Results 91 to 100 of about 92,853 (340)

Association of Digoxin With Interstage Mortality: Results From the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Use Dataset

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background Mortality for infants with single ventricle congenital heart disease remains as high as 8% to 12% during the interstage period, the time between discharge after the Norwood procedure and before the stage II palliation.
M. Oster, M. Kelleman, C. McCracken, R. Ohye, W. Mahle   +4 more
semanticscholar   +1 more source

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta [PDF]

, 2013
Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the
Balskus, Emily Patricia, Chatman, Kelly, Gootenberg, David Benjamin, Haiser, Henry J., Sirasani, Gopal, Turnbaugh, Peter   +5 more
core   +1 more source

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source

Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation (AF). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation.
Daniele Pastori, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Marta Novo, Vittoria Cammisotto, Silvia Piconese, Maria Santulli, Fortunata Vasaturo, Francesco Violi, Pasquale Pignatelli   +10 more
doaj   +1 more source

Digoxin-induced retinal degeneration depends on rhodopsin [PDF]

, 2017
Na,K-ATPases are energy consuming ion pumps that are required for maintaining ion homeostasis in most cells. In the retina, Na,K-ATPases are especially important to sustain the dark current in photoreceptor cells needed for rapid hyperpolarization of ...
Landfried, Britta, Samardzija, Marijana, Barben, Maya, Schori, Christian, Klee, Katrin, Storti, Federica, Grimm, Christian   +6 more
core   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Effects of Age, Gender, and Comorbid Diseases on Serum Digoxin Levels During Digoxin Treatment

Bezmiâlem Science, 2018
Objective:Digoxin is widely used in controlling ventricular rhythm in atrial fibrillation and heart failure. Therapeutic serum levels of digoxin are 0.5–2 ng/mL. Toxicity may occur after acute accidental or suicidal ingestion or with chronic therapy.
Zeynep ÖZTÜRK, Serap ÇUHADAR
doaj   +1 more source

A pharmacokinetic study of digoxin holiday dosing practice in Egypt: A prospective-randomized trial

Bulletin of Faculty of Pharmacy Cairo University, 2016
Background: Because of the narrow therapeutic index of digoxin, most cardiologists in Egypt give digoxin holiday for atrial fibrillation and heart failure, it is not clear if the interrupted digoxin regimens are effective since serum digoxin ...
S.A. Alshabasy, M.M. Abbassi, M.S. Mohamed, S.F. Farid   +3 more
doaj   +1 more source