Results 71 to 80 of about 36,624 (198)

Incretin‐Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice

Obesity Reviews, EarlyView.
ABSTRACT Introduction Pregnancy concurrent with incretin‐based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin‐based medications in relation to preconception, pregnancy, and postnatal health, and to propose ...
Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart, Sam Schoenmakers, Amihai Rottenstreich, Heather Hopper, Mojca Jensterle, Angela C. Flynn, Sarah Siegelaar, Annick Bogaerts, Isy Douek, Nicola Heslehurst, Dries Ceulemans, Tricia Tan, Johnathan Pinkney, Martin Whyte, Shahrad Taheri, Roland Devlieger   +19 more
wiley   +1 more source

Inhibition of P-glycoprotein–Mediated Efflux of Digoxin and Its Metabolites by Macrolide Antibiotics

Journal of Pharmacological Sciences, 2010
This study was conducted to determine the rate of P-glycoprotein (P-gp)–mediated efflux of digoxin analogues and metabolites and to assess the effects of macrolide antibiotics on this efflux.
Jeff Hughes, Andrew Crowe
doaj   +1 more source

Inpatient Cardiac Resynchronization Therapy During Heart Failure Hospitalization: A Distinct High‐Risk Phenotype

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background The role of cardiac resynchronization therapy (CRT) during hospitalization for heart failure (HFH) is uncertain, because hospitalized patients were routinely excluded from landmark CRT trials. Despite this, CRT implantation during HFH is common.
Oliver Rees, James Dargan, Jemima Weir, Robin Ray, Giuseppe Rosano, Fadi Johura   +5 more
wiley   +1 more source

EFFECTS OF MONENSIN SODIUM ON DIGOXIN KINETICS IN CONSCIOUS MALE RABBITS

Zagazig Journal of Pharmaceutical Sciences, 2001
The investigation was performed on male rabbits equally divided into two groups: digoxin treated group and monensin plus digoxin treated group. Digoxın (0.2 mg/kg) was administered orally as a single dose to normal and monensin (6mg/kg for three ...
Atef El-Gharbawy
doaj   +1 more source

Safety of Intra‐Amniotic and Intra‐Fetal Digoxin Administration in Late Second‐Trimester Abortion by Dilation and Evacuation

Perspectives on Sexual and Reproductive Health, EarlyView.
ABSTRACT Objective The study's purpose was to determine the safety of two routes and doses of digoxin through assessment of systemic absorption, cardiac rhythm, and coagulation parameters injected as part of second‐trimester dilation and evacuation abortion.
Eleanor A. Drey, Nora Goldschlager, Neal L. Benowitz, Abby Sokoloff, Rebecca A. Jackson   +4 more
wiley   +1 more source

Falling into complexity: A case of digitalis-induced fall, trauma, symptomatic bradycardia, and syncope

Journal of Family Medicine and Primary Care
Digoxin, a cardiac glycoside, functions by inhibiting the sodium potassium ATPase pump. It’s crucial to note that digoxin has a very narrow therapeutic range. Its serum level vary due to changes in body weight, age, renal function, hepatic impairment and
Rajathadri H. Ravikumar, Baby Pegu, Himanti Bansal, Kapil Dev Soni   +3 more
doaj   +1 more source

Predicting the serum digoxin concentrations of infants in the neonatal intensive care unit through an artificial neural network

BMC Pediatrics, 2019
Background Given its narrow therapeutic range, digoxin’s pharmacokinetic parameters in infants are difficult to predict due to variation in birth weight and gestational age, especially for critically ill newborns. There is limited evidence to support the
Shu-Hui Yao, Hsiang-Te Tsai, Wen-Lin Lin, Yu-Chieh Chen, Chiahung Chou, Hsiang-Wen Lin   +5 more
doaj   +1 more source

A pharmacokinetic study of digoxin holiday dosing practice in Egypt: A prospective-randomized trial

Bulletin of Faculty of Pharmacy Cairo University, 2016
Background: Because of the narrow therapeutic index of digoxin, most cardiologists in Egypt give digoxin holiday for atrial fibrillation and heart failure, it is not clear if the interrupted digoxin regimens are effective since serum digoxin ...
S.A. Alshabasy, M.M. Abbassi, M.S. Mohamed, S.F. Farid   +3 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source