Results 31 to 40 of about 58,682 (199)

Improving Postdischarge Outcomes in Acute Heart Failure [PDF]

, 2018
The global burden that acute heart failure (AHF) carries has remained unchanged over the past several decades (1). European registries (2–5) showed that 1-year outcome rates remain unacceptably high (Table 1) and confirm that hospitalization for AHF ...
Ambrosy, Andrew P., Antohi, Elena-Laura, Butler, Javed, Chioncel, Ovidiu, Collins, Sean P., Iliescu, Vlad Anton, Maggioni, Aldo P., Mebazaa, Alexandre, Pang, Peter S.   +8 more
core   +1 more source

Digoxin, an Overlooked Agonist of RORγ/RORγT

Frontiers in Pharmacology, 2019
Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects.
Kaja Karaś, Anna Sałkowska, M. Sobalska-Kwapis, A. Walczak-Drzewiecka, Dominik Strapagiel, J. Dastych, R. Bachorz, M. Ratajewski   +7 more
semanticscholar   +1 more source

Digoxin for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and trial sequential analysis of randomised clinical trials

PLoS ONE, 2018
Background During recent years, systematic reviews of observational studies have compared digoxin to no digoxin in patients with atrial fibrillation or atrial flutter, and the results of these reviews suggested that digoxin seems to increase the risk of ...
N. Sethi, E. Nielsen, Sanam Safi, J. Feinberg, C. Gluud, J. Jakobsen   +5 more
semanticscholar   +1 more source

Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report [PDF]

, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org ...
Chan, Mark, G, Natasha, Gorog, Diana, Gue, Ying X.   +3 more
core   +2 more sources

Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices

Circulation: Heart Failure, 2018
Background Gastrointestinal bleeding (GIB) is one of the principal adverse events affecting patients with continuous-flow left ventricular assist devices (CF-LVADs).
S. Vukelic, P. Vlismas, Snehal R. Patel, X. Xue, Sanyog G. Shitole, O. Saeed, D. Sims, T. Chinnadurai, Julia J. Shin, S. Forest, D. Goldstein, U. Jorde   +11 more
semanticscholar   +1 more source

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis [PDF]

, 2005
BACKGROUND AND AIMS: The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with ...
Arnott, Ian D, Drummond, Hazel, Fennell, Janice, Ho, Gwo-Tzer, Mowat, Craig, Nimmo, Elaine R, Satsangi, Jack, Tenesa, Albert   +7 more
core   +1 more source

Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data

British medical journal, 2015
Objective To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods.
O. Ziff, D. Lane, Monica Samra, Michael Griffith, P. Kirchhof, G. Lip, R. Steeds, J. Townend, D. Kotecha   +8 more
semanticscholar   +1 more source

Randomised controlled trial of specialist nurse intervention in heart failure [PDF]

, 2001
<p>Objectives. To determine whether specialist nurse intervention improves outcome in patients with chronic heart failure.</p> <p>Design. Randomised controlled trial.</p> <p>Setting.
Blue, L., Connolly, E., Davie, A.P., Ford, I., Lang, E., McDonagh, T.A., McMurray, J.J.V., Morrison, C., Murdoch, D.R., Norrie, J., Petrie, M.C., Round, C.E.   +11 more
core   +2 more sources

Improvement of Adequate Digoxin Dosage: An Application of Machine Learning Approach

Journal of Healthcare Engineering, 2018
Digoxin is a high-alert medication because of its narrow therapeutic range and high drug-to-drug interactions (DDIs). Approximately 50% of digoxin toxicity cases are preventable, which motivated us to improve the treatment outcomes of digoxin.
Ya-Han Hu, Chun-Tien Tai, Chih-Fong Tsai, Min-Wei Huang   +3 more
semanticscholar   +1 more source

Adapting clinical guidelines to take account of multimorbidity [PDF]

, 2012
Most people with a chronic condition have multimorbidity, but clinical guidelines almost entirely focus on single conditions. It will never be possible to have good evidence for every possible combination of conditions, but guidelines could be made more ...
Alderson, P., Guthrie, B., McMurdo, M.E.T., Mercer, S.W., Payne, K.   +4 more
core   +1 more source