Results 41 to 50 of about 62,419 (246)

Digoxin and Heart Failure: Are We Clear Yet?

Cardiovascular Innovations and Applications, 2017
The Digoxin Investigation Group trial has multiple flaws in the trial design for the findings to be universally applicable. Digoxin in low serum concentrations (0.5–0.9 ng/mL) has been shown to decrease mortality in heart failure patients.
Amit Gupta, Melissa Dakkak, Alan Miller
doaj   +1 more source

Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
Non-small cell lung cancer is the predominant type of lung cancer, resulting in high mortality worldwide. Digoxin, a cardiac glycoside, has recently been suggested to be a novel chemotherapeutic agent.
Sheng-Yi Lin, Hsiu-Hui Chang, Yi-Hua Lai, Ching-Hsiung Lin, Min-Hsuan Chen, Gee-Chen Chang, Meng-Feng Tsai, Jeremy J W Chen   +7 more
doaj   +1 more source

Recognize and Treatment of Digitalis Intoxication

Majalah Kardiologi Indonesia, 2013
Background: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common ...
Dewi H Suprobo, Bambang B Siswanto, Yoga Yuniadi, Ganesja M Harimurti   +3 more
doaj   +1 more source

The effect of different digoxin concentrations on heart tissue and antioxidant status in iron-overloaded rats

ARYA Atherosclerosis, 2018
BACKGROUND: Thalassaemia is a hereditary disorder and has an economic burden on patients and the government. The most prevalent complication in these patients is iron overload which is followed by cardiomyopathy.
Beydolah Shahouzehi, Hamid Reza Nasri, Yaser Masoumi-Ardakani   +2 more
doaj   +1 more source

Digoxin use after diagnosis of prostate cancer and survival: a population-based cohort study [PDF]

, 2016
PURPOSE:Preclinical studies have shown that digoxin exerts anticancer effects on different cancer cell lines including prostate cancer. A recent observational study has shown that digoxin use was associated with a 25% reduction in prostate cancer risk ...
Cardwell, Chris R., Hughes, Carmel M., Karasneh, Reema A., Murray, Liam J.   +3 more
core   +1 more source

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Junctional Bradycardia as Early Sign of Digoxin Toxicity in a Premature Infant with Congestive Heart Failure due to a Left to Right Shunt

American Journal of Perinatology Reports, 2016
Introduction Congestive heart failure due to left to right cardiac shunt is usually managed medically with diuretics, angiotensin converting enzyme inhibitors, and, in some cases, with the addition of digoxin.
Soham Dasgupta, Ashraf M. Aly, Sunil K. Jain   +2 more
doaj   +1 more source

The Evolving Role of Ivabradine for Focal Atrial Tachycardia: A Systematic Review. [PDF]

J Arrhythm
Overview of the evolving role of ivabradine in focal atrial tachycardia (FAT), highlighting its HCN‐mediated mechanism, features of ivabradine‐sensitive FAT, hypothesized predictors of response, special populations requiring special considerations, and potential adverse effects.
Balweel H, Eri RR, Zahrani S, Quinncilla KH, Tafriend NA, Harsoyo A.   +5 more
europepmc   +2 more sources

Digitalis for treatment of heart failure in patients in sinus rhythm [PDF]

, 2014
<b>Background</b><p></p> Digitalis glycosides have been in clinical use for the treatment of heart failure (HF) for longer than 200 years.
Dans, Antonio L, Guyatt, Gordon H, Hood, Jr., William B, Jaeschke, Roman, McMurray, John JV   +4 more
core   +1 more source

Treatment with Digoxin – is it a clinical challenge? A Retrospective Analysis of Hospitalizations due to Digoxin intoxication

Journal of Education, Health and Sport
Introduction and purpose: Digoxin, a cardiac glycoside derived from Digitalis lanata, has stood as a cornerstone in the treatment of various cardiovascular disorders for centuries.
Marcin Wais, Marlena Zając, Dariusz Gruca, Paweł Zalewski, Wiktor Wróblewski, Adam Raabe, Michał Tchórz   +6 more
doaj   +1 more source