Results 51 to 60 of about 92,853 (340)

Digoxin-associated mortality: a systematic review and meta-analysis of the literature.

European Heart Journal, 2015
There are conflicting data regarding the effect of digoxin use on mortality in patients with atrial fibrillation (AF) or with congestive heart failure (CHF).
M. Vámos, J. Erath, S. Hohnloser
semanticscholar   +1 more source

Treatment with Digoxin – is it a clinical challenge? A Retrospective Analysis of Hospitalizations due to Digoxin intoxication

Journal of Education, Health and Sport
Introduction and purpose: Digoxin, a cardiac glycoside derived from Digitalis lanata, has stood as a cornerstone in the treatment of various cardiovascular disorders for centuries.
Marcin Wais, Marlena Zając, Dariusz Gruca, Paweł Zalewski, Wiktor Wróblewski, Adam Raabe, Michał Tchórz   +6 more
doaj   +1 more source

The effect of different digoxin concentrations on heart tissue and antioxidant status in iron-overloaded rats

ARYA Atherosclerosis, 2018
BACKGROUND: Thalassaemia is a hereditary disorder and has an economic burden on patients and the government. The most prevalent complication in these patients is iron overload which is followed by cardiomyopathy.
Beydolah Shahouzehi, Hamid Reza Nasri, Yaser Masoumi-Ardakani   +2 more
doaj   +1 more source

Acute myocardial uptake of digoxin in humans: Correlation with hemodynamic and electrocardiographic effects [PDF]

, 1990
Acute myocardial uptake of digoxin was measured at a constant paced heart rate (75 beats/min) for 30 min after an intravenous bolus injection of 500 µg of digoxin in 14 patients with ischemic heart disease.
Hasin, Yonathan, Horomidis, Soumela, Horowitz, John D., Louis, William J., Powell, Anne C., Syrjanen, Marie L.   +5 more
core   +1 more source

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

BMC Medicine, 2004
Background The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin.
Michaëlsson Karl, Artursson Per, Hallberg Pär, Englund Gunilla, Melhus Håkan   +4 more
doaj   +1 more source

Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data

British medical journal, 2015
Objective To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods.
O. Ziff, D. Lane, Monica Samra, Michael Griffith, P. Kirchhof, G. Lip, R. Steeds, J. Townend, D. Kotecha   +8 more
semanticscholar   +1 more source

Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]

, 2016
Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian, Jhund, Pardeep S., Lefkowitz, Martin P., McMurray, John J.V., Okumura, Naoki, Packer, Milton, Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +11 more
core   +2 more sources

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Improvement of Adequate Digoxin Dosage: An Application of Machine Learning Approach

Journal of Healthcare Engineering, 2018
Digoxin is a high-alert medication because of its narrow therapeutic range and high drug-to-drug interactions (DDIs). Approximately 50% of digoxin toxicity cases are preventable, which motivated us to improve the treatment outcomes of digoxin.
Ya-Han Hu, Chun-Tien Tai, Chih-Fong Tsai, Min-Wei Huang   +3 more
semanticscholar   +1 more source

Does Digoxin Provide Additional Hemodynamic and Autonomic Benefit at Higher Doses in Patients With Mild to Moderate Heart Failure and Normal Sinus Rhythm? [PDF]

, 1997
Objectives. This study sought to examine the hemodynamic and autonomic dose response to digoxin.Background. Previous studies have demonstrated an increase in contractility and heart rate variability with digitalis preparations.
Eichhorn, Eric J, Grayburn, Paul A, Hall, Shelley A, Irani, Waleed N, Marcoux, Lucille G, Page, Richard L, Slatton, Monte L   +6 more
core   +1 more source