Results 61 to 70 of about 43,790 (236)

Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation (AF). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation.
Daniele Pastori, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Marta Novo, Vittoria Cammisotto, Silvia Piconese, Maria Santulli, Fortunata Vasaturo, Francesco Violi, Pasquale Pignatelli   +10 more
doaj   +1 more source

Comparative effectiveness of pharmacotherapy for heart failure with preserved ejection fraction: A systematic review and network meta‐analysis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim Heart failure with preserved ejection fraction (HFpEF) presents a therapeutic challenge, characterised by a paucity of validated treatments. Emerging data suggest that targeting adiposity is central to HFpEF pathogenesis. We conducted an updated network meta‐analysis to compare the efficacy of emerging and established HFpEF therapies ...
Szu‐Han Chen, Yu‐Wen Tseng, Chi‐Jung Huang, Shu‐Mei Yang, Marat Fudim, Shao‐Yuan Chuang, Shih‐Hsien Sung, Hao‐Min Cheng   +7 more
wiley   +1 more source

Intrinsic Influences on Medical Emergency Team Call Stand‐Down Decision‐Making: An Observational Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim The aim of this research was to describe factors that influence Intensive Care Unit liaison nurses' decision to stand down a medical emergency team call response. The decision to end a medical emergency team response for a deteriorating patient is referred to as the medical emergency team call stand‐down decision.
Natalie A. Kondos, Jo McDonall, Jonathan Barrett, Tracey Bucknall   +3 more
wiley   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

A pharmacokinetic study of digoxin holiday dosing practice in Egypt: A prospective-randomized trial

Bulletin of Faculty of Pharmacy Cairo University, 2016
Background: Because of the narrow therapeutic index of digoxin, most cardiologists in Egypt give digoxin holiday for atrial fibrillation and heart failure, it is not clear if the interrupted digoxin regimens are effective since serum digoxin ...
S.A. Alshabasy, M.M. Abbassi, M.S. Mohamed, S.F. Farid   +3 more
doaj   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Digoxin Use to Control Ventricular Rate in Patients with Atrial Fibrillation and Heart Failure Is Not Associated with Increased Mortality

Cardiology Research and Practice, 2015
Introduction. Digoxin is used to control ventricular rate in atrial fibrillation (AF). There is conflicting evidence regarding safety of digoxin. We aimed to evaluate the risk of mortality with digoxin use in patients with AF using meta-analyses. Methods.
Surbhi Chamaria, Anand M. Desai, Pratap C. Reddy, Brian Olshansky, Paari Dominic   +4 more
doaj   +1 more source

Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction

ESC Heart Failure, 2020
Aims The aim of this study was to investigate the impact of digoxin use on the outcomes of patients with heart failure with reduced ejection fraction (HFrEF) and its possible interaction with atrial fibrillation or use of currently guideline‐recommended ...
Jingmin Zhou, Juan Cao, Xuejuan Jin, Jun Zhou, Zhenyue Chen, Dingli Xu, Xinchun Yang, Wei Dong, Liwen Li, Yuyuan Fan, Li Chen, Qiaoqing Zhong, Micheal Fu, Kai Hu, Junbo Ge, CN‐HF investigators   +15 more
doaj   +1 more source