Results 61 to 70 of about 92,853 (340)
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
‘Digoxin conundrum – Time for validation?’
Indian Heart Journal, 2021 Despite no incontrovertible data, Digoxin use has been demonised. As a consequence, a lot of patients, stable on Digoxin, have been taken off it and offered alternative drugs.
O.P. Yadava
doaj
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Digoxin acutely increases cardiac output in patients with pulmonary arterial hypertension (PAH) and right ventricular failure; however, the effects of chronic digoxin use in PAH are unclear.
Kevin Y. Chang +8 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Objective To determine the optimal anticoagulation intensity of warfarin in a South‐East Asian population with moderate‐to‐severe rheumatic mitral stenosis. Methods A multicentre, retrospective study examined patients with rheumatic mitral stenosis who had not undergone valve replacement or repair and required long‐term warfarin therapy at two ...
Punyawee Puchsaka +6 more
wiley +1 more source
Drugs - Real World Outcomes, 2023 Background Cardiac glycosides such as digoxin, digitoxin and ouabain are still used around the world to treat patients with chronic heart failure with reduced ejection fraction (HFrEF) and/or atrial fibrillation (AF).
Amanda L. Banaag +2 more
doaj +1 more source
Assumption versus evidence: the case of digoxin in atrial fibrillation and heart failure
European Heart Journal, 2017 Despite development of new and innovative medical therapies, still millions of patients with chronic heart failure (HF) with reduced ejection fraction and/or atrial fibrillation (AF) are treated with cardiac glycosides (overall 122 millions of patients ...
U. Bavendiek +3 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims To develop an evidence‐ and consensus‐based patient prioritization tool for use by UK mental health inpatient pharmacy teams. Methods A modified‐Delphi technique was used to obtain experts' agreement on the content, design and practical use of the patient prioritization tool.
Fatima Q. Alshaikhmubarak +3 more
wiley +1 more source
Management of digoxin toxicity.
Australian Prescriber, 2016 Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms.
M. Pincus
semanticscholar +1 more source
Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]
, 2012 Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang +3 more
wiley +1 more source