Results 11 to 20 of about 264 (104)
Hematoporphyrin derivative (HPD) and its newly purified form, dihematoporphyrin ether (DUE) have been shown to selectively localize in malignant tissues and virally induced papillomas (Sliikowitz et.al.). Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by ultraviolet light.
Mark J Shikowitz
exaly +3 more sources
Abstract The fluorescent molecule dihematoporphyrin ether (DHE), which is known to become sequestered in cells and which is currently being used for “photoradiation” cancer therapy in clinical trials, may organize into two-dimensional arrays at a water-membrane interface.
Dietmar Möbius
exaly +4 more sources
Chloroaluminum sulfonated phthalocyanine versus dihematoporphyrin ether: Early vascular events in the rat window chamber [PDF]
AbstractThe development of a simple and well‐tolerated rat window chamber has allowed direct comparison of the vascular effects of two photosensitizers, chloroaluminum sulfonated phthalocyanine (CASP) and dihematoporphyrin ether (DHE).CASP and DHE were given 4 days after the implantation of the window chamber.
S J, Stern +4 more
openaire +3 more sources
Dihematoporphyrin Ether Clearance in Primate Bladders
The techniques of in vivo tissue fluorescence photometry and chemical extractions of DHE, which have been recently developed in our laboratory, were employed to study DHE uptake and clearance in the primate bladders. Data show these techniques are readily applicable in studying porphyrin uptake and clearance in primate bladders.
U O, Nseyo, T S, Mang, W R, Potter
openaire +3 more sources
Results of dihematoporphyrin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40-60 μg DHE/g of tissue at an injected dose of 40 mg/kg. Previously concentrations on this order have only been found in organs of the reticuloendothelial system.
Thomas S. Mang, Thomas J. Wieman
openaire +2 more sources
Drug-induced photosensitivity: culprit drugs, potential mechanisms and clinical consequences. [PDF]
Summary Drug‐induced photosensitivity, the development of phototoxic or photoallergic reactions due to pharmaceuticals and subsequent exposure to ultraviolet or visible light, is an adverse effect of growing interest. This is illustrated by the broad spectrum of recent investigations on the topic, ranging from molecular mechanisms and culprit drugs ...
Hofmann GA, Weber B.
europepmc +2 more sources
Successful Treatment of Adult-Onset Recurrent Respiratory Papillomatosis with CO2 Laser and Photodynamic Therapy. [PDF]
Recurrent respiratory papillomatosis is a noninvasive benign epithelial tumor caused by human papillomavirus. Clinically, it featured rapid growth, multifocus, and frequent recurrence. Though a number of therapies have been investigated, the recurrence after treatment is always a challenge.
Lu S, Liu Y, Shi R, Zhou P, Zhou P.
europepmc +2 more sources
Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies. [PDF]
We highlight the development and molecular mechanisms underlying the activation of photosensitizers, the challenges of PDT in tumor management, and the advantages of nanocarriers‐based PDT against cancer. Abstract Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, and potentially highly efficient method of ...
Zhao W +8 more
europepmc +2 more sources

