Results 111 to 120 of about 6,942 (191)

Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria. [PDF]

, 2015
This prospective trial investigated the population pharmacokinetics of piperaquine given with dihydroartemisinin to treat uncomplicated malaria in 107 Ugandan children 6 months to 2 years old, an age group previously unstudied.
Parikh, S, Arinaitwe, E, Bigira, V, Creek, D J, Wanzira, H, Sambol, N C, Kakuru, A, Lindegardh, N, Tarning, J, McCormack, S A, Yan, L, Nosten, F, Aweeka, F T, Tappero, J W   +13 more
core   +1 more source

A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

npj Vaccines
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potential interactions of this combination affecting
Borimas Hanboonkunupakarn, Mavuto Mukaka, Podjanee Jittamala, Kittiyod Poovorawan, Pongphaya Pongsuwan, Lisa Stockdale, Samuel Provstgaard-Morys, Kesinee Chotivanich, Joel Tarning, Richard M. Hoglund, Natenapa Chimjinda, Katie Ewer, Fernando Ramos-Lopez, Nicholas P. J. Day, Arjen M. Dondorp, Adrian V. Hill, Nicholas J. White, Lorenz von Seidlein, Sasithon Pukrittayakamee   +18 more
doaj   +1 more source

Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion

Nature Communications
Genetic surveillance of Plasmodium falciparum (Pf) can track antimalarial-resistant strains, to inform decision-making by National Malaria Control Programmes (NMCPs).
Varanya Wasakul, Tess D. Verschuuren, Nguyen Thuy-Nhien, Ethan Booth, Huynh Hong Quang, Ngo Duc Thang, Keobouphaphone Chindavongsa, Siv Sovannaroth, Virasak Banouvong, Viengphone Sengsavath, Mayfong Mayxay, Nguyen Thi Kim Tuyen, Vo Ngoc Lam Phuong, Pham Duc Trung, Sónia Gonçalves, Soun Chen, Sonexay Phalivong, Saiamphone Xayvanghang, Supaporn Mahaphontrakoon, Richard D. Pearson, Paul N. Newton, Richard J. Maude, Elizabeth A. Ashley, Cristina V. Ariani, Victoria J. Simpson, Nicholas P. Day, Arjen M. Dondorp, Olivo Miotto   +27 more
doaj   +1 more source

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance

Nature Communications
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear.
Gabrielle C. Ngwana-Joseph, Jody E. Phelan, Emilia Manko, Jamille G. Dombrowski, Simone da Silva Santos, Martha Suarez-Mutis, Gabriel Vélez-Tobón, Alberto Tobón Castaño, Ricardo Luiz Dantas Machado, Claudio R. F. Marinho, Debbie Nolder, François Nosten, Colin J. Sutherland, Susana Campino, Taane G. Clark   +14 more
doaj   +1 more source

Towards Intermittent Preventive Therapy in Pregnancy with Dihydroartemisinin‐Piperaquine?

Clinical Pharmacology & Therapeutics, 2021
openaire   +3 more sources

Effects of malaria intermittent preventive treatment with dihydroartemisinin-piperaquine on antiretroviral drug concentrations in African pregnant women living with HIV. [PDF]

Antimicrob Agents Chemother
Stöger L, Mischlinger J, Nhampossa T, Mombo-Ngoma G, Esen M, Tchouatieu A-M, Brunet M, Mendes A, Dimessa Mbadinga LB, Gamberini S, Ndzebe Ndoumba W, Figueroa-Romero A, Lell B, Lagler H, Zoleko-Manego R, El Gaaloul M, Méndez S, Botella N, Sanz S, Piqueras M, Sevene E, Saúte F, Wicha SG, Soy D, Menéndez C, Ramharter M, González R, MAMAH Study Group.   +27 more
europepmc   +1 more source

Efficacy of dihydroartemisinin-piperaquine to prevent malaria and complication-related malaria during pregnancy compared to sulfadoxine-pyrimethamine: a systematic review, meta-analysis, and meta-regression. [PDF]

Epidemiol Infect
Simanjuntak AMT, Wijayanto FPS, Nugraha RTH, Prathama FH, Ramadhan RN, Mulya Perdana T, Haposan JH, Nugrahani AD, Hartantri Y, Maulana S.   +9 more
europepmc   +1 more source

Impact of intermittent preventive treatment for malaria in pregnancy with sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and their combination on infant outcomes: A randomized controlled trial. [PDF]

Clin Infect Dis
Nankabirwa JI, Kakuru A, Nguyen AT, Roh ME, Aguti M, Adrama H, Kizza J, Olwoch P, Camanag K, Benjamin-Chung J, Rosenthal PJ, Kamya MR, Dorsey G, Jagannathan P.   +13 more
europepmc   +1 more source

Maternal, Fetal, and Neonatal Outcomes of Additional Dihydroartemisinin-Piperaquine to Trimethoprim-Sulfamethoxazole in Intermittent Preventive Treatment for Malaria in HIV-Positive Pregnancies: A Systematic Review and Meta-Analysis. [PDF]

Ther Clin Risk Manag
Yunivita V, Maharani AJ, Bernadus CA, Sinaga EIJ, Simanjuntak ER.   +4 more
europepmc   +1 more source

Agent-based simulation of seasonal malaria chemoprevention strategy in Southern Tanzania: comparing dihydroartemisinin-piperaquine with or without primaquine. [PDF]

Malar J
Mfala CT, Nyambo DG, Mwaiswelo RO, Tchuenche JM, Clemen T.   +4 more
europepmc   +1 more source