Results 91 to 100 of about 6,942 (191)

A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.

, 2008
We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different ...
Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., Karema, C., Van Doren, W., Ndahindwa, V, Uwimana, A, Van Overmeir, C, Uwimana, A., Fanello, CI, Van Doren, W, Van Overmeir, C., Ndahindwa, V., D'Alessandro, U, Curtis, J., Karema, C, Curtis, J   +17 more
core   +1 more source

Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal

Malaria Journal, 2017
Background The monitoring of Plasmodium falciparum sensitivity to anti-malarial drugs is a necessity for effective case management of malaria. This species is characterized by a strong resistance to anti-malarial drugs.
Aminata Mbaye, Amy Gaye, Baba Dieye, Yaye D. Ndiaye, Amy K. Bei, Muna Affara, Awa B. Deme, Mamadou S. Yade, Khadim Diongue, Ibrahima M. Ndiaye, Tolla Ndiaye, Mouhamed Sy, Ngayo Sy, Ousmane Koita, Donald J. Krogstad, Sarah Volkman, Davis Nwakanma, Daouda Ndiaye   +17 more
doaj   +1 more source

A randomized trial of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali

Malaria Journal, 2018
Background Artemether–lumefantrine (AL) and artesunate–amodiaquine are first-line treatment for uncomplicated malaria in many endemic countries, including Mali.
Souleymane Dama, Hamidou Niangaly, Moussa Djimde, Issaka Sagara, Cheick Oumar Guindo, Amatigue Zeguime, Antoine Dara, Abdoulaye A. Djimde, Ogobara K. Doumbo   +8 more
doaj   +1 more source

Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults.

, 2006
OBJECTIVE: To assess the tolerability and efficacy of amodiaquine (AQ)+sulphadoxine-pyrimethamine (SP), the first-line malaria treatment in Rwanda. METHOD: Randomized, double-blind trial in 2003 in Kigali town.
Karema, Corine, D'Alessandro, U., Fanello, C. I., van Doren, W., Rwagacondo, C. E., van Doren, W, Karema, C., Fanello, Caterina I, D'Alessandro, Umberto, Fanello, CI, van Doren, Walli, D'Alessandro, U, Karema, C, Rwagacondo, CE, Rwagacondo, Claude E   +14 more
core   +1 more source

Risk of sudden unexplained death after use of dihydroartemisinin-piperaquine for malaria: A systematic review and Bayesian meta-analysis [PDF]

, 2018
Background Dihydroartemisinin–piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria.
White, Nicholas J., Josep Brugada, Mawer, LJ, Win, YN, Chan, XHS, Nicholas J White, Tan, JY, Jireh Y Tan, Yan Naung Win, White, NJ, Xin Hui S Chan, Brugada, J, Chan, Xin H.S., Laura J Mawer   +13 more
core   +1 more source

Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam

Malaria Journal, 2019
Background Reduced artemisinin susceptibility and artemisinin-based combination therapy (ACT)-resistance against Plasmodium falciparum and chloroquine (CQ)-resistant P. vivax malaria has been reported in Vietnam.
Nguyen Chinh Phong, Marina Chavchich, Huynh Hong Quang, Nguyen Ngoc San, Geoffrey W. Birrell, Ilin Chuang, Nicholas J. Martin, Nguyen Duc Manh, Michael D. Edstein   +8 more
doaj   +1 more source

A randomised trial to assess the safety and efficacy of artemether-lumefantrine (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda.

, 2006
Coartem is a fixed-dose combination of artemether-lumefantrine that, given in six doses, provides effective treatment for children with uncomplicated Plasmodium falciparum infection in areas with highly endemic and multidrug-resistant malaria.
Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., van Doren, W, van Doren, W., Karema, C., Van Overmeir, C, Fanello, CI, Van Overmeir, C., Van Overmeir, Chantal, D'Alessandro, U, Karema, C   +12 more
core   +1 more source

Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine

BMC Infectious Diseases, 2019
Background Treatment for severe malaria must be prompt with effective parenteral antimalarial drugs for at least 24 h to achieve fast parasite clearance, and when the patient can tolerate oral therapy, treatment should be completed with effective ...
Pauline Byakika-Kibwika, Ronald Ssenyonga, Mohammed Lamorde, Daniel Blessborn, Joel Tarning   +4 more
doaj   +1 more source

Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa

Malaria Journal, 2011
Background The choice of appropriate artemisinin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate and simplicity of administration). To assess whether the combination dihydroartemisinin-piperaquine (DP) could
Yavo William, Faye Babacar, Kuete Thomas, Djohan Vincent, Oga Serge A, Kassi Richard R, Diatta Mariama, Ama Moor V, Tine Roger, Ndiaye Jean-Louis, Evi Jean-Bedel, Same-Ekobo Albert, Faye Oumar, Koné Moussa   +13 more
doaj   +1 more source

Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects [PDF]

, 2009
The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects.
Geue, J. P., Addison, R. S., Dai, B., Chinh, N.T., Edstein, M. D., Thanh, N. X., Quang, N. Q., Travers, T.   +7 more
core   +1 more source