Results 71 to 80 of about 6,942 (191)

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine [PDF]

Malaria Journal, 2014
The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine.
Lon, Chanthap, Spring, Michele, Sok, Somethy, Chann, Soklyda, Bun, Rathvichet, Ittiverakul, Mali, Buathong, Nillawan, Thay, Khengheng, Kong, Nareth, You, Yom, Kuntawunginn, Worachet, Lanteri, Charlotte A, Saunders, David L   +12 more
openaire   +2 more sources

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015

Emerging Infectious Diseases, 2018
One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum.
Himanshu Gupta, Eusebio Macete, Helder Bulo, Crizolgo Salvador, Marian Warsame, Eva Carvalho, Didier Ménard, Pascal Ringwald, Quique Bassat, Sonia Enosse, Alfredo Mayor   +10 more
doaj   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023

Tropical Medicine &International Health, Volume 31, Issue 1, Page 43-48, January 2026.
ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Albert Dennis Kegya, Elizabeth Oppong, Eric Darko, Kwame Ayisi Boateng, Richard Odame Phillips, Melina Heinemann, Michael Ramharter, Clement Igiraneza, Jules Minega Ndoli, Frank P. Mockenhaupt, Welmoed van Loon   +10 more
wiley   +1 more source

Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomized safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine, and primaquine in healthy Thai adult volunteers

Human Vaccines & Immunotherapeutics, 2020
Introduction: RTS,S/AS01 is currently the most advanced malaria vaccine but provides incomplete, short-term protection. It was developed for use within the expanded program on immunizations (EPI) for African children. Another use could be adding mass RTS,
Lorenz von Seidlein, Borimas Hanboonkunupakarn, Podjanee Jittamala, Pongphaya Pongsuwan, Kesinee Chotivanich, Joel Tarning, Richard M. Hoglund, Markus Winterberg, Mavuto Mukaka, Pimnara Peerawaranun, Pasathorn Sirithiranont, Zoe Doran, Christian F. Ockenhouse, Karen Ivinson, Cynthia Lee, Ashley J. Birkett, David C. Kaslow, Pratap Singhasivanon, Nicholas P.J. Day, Arjen M. Dondorp, Nicholas J. White, Sasithon Pukrittayakamee   +21 more
doaj   +1 more source

Prevalence of Plasmodium Species Using Rapid Diagnostic Tests in Cameroon: First‐Year Data From Routine Malaria Surveillance

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a major public health concern in Cameroon. Although Plasmodium falciparum is the predominant parasite, the prevalence of other Plasmodium species remains poorly documented due to the absence of a formal surveillance system.
Raymond Ngomdjum Tabue, Flora Neh, Elvira Evina, Dominique Amougou Bomba, Junior Voundi Voundi, Jean Fosso, Albert Meka Zeh, Yoel A. Klug   +7 more
wiley   +1 more source

Genetic Profiles of Plasmodium falciparum Isolates from a Therapeutic Efficacy Study on the Antimalarial Drug Dihydroartemisinin-Piperaquine in the West Sumba and Kupang Districts of East Nusa Tenggara Province, Indonesia [PDF]

BIO Web of Conferences
Artemisinin resistance, first reported on the Thai-Cambodian border in 2009, has spread across Southeast Asia, characterized by delayed parasite clearance. Extended artemisinin-based combination therapy (ACT) regimens have shown efficacy where standard 3-
Irdayanti, Aswad Hijral, Asih Puji BS, Rozi Ismail E., Basri Herdiana H., Diptyanusa Ajib, Prameswari Helen D., Yusuf Yenni, Bahrani, Hidayah Najdah, Artika I Made, Syafruddin Din   +11 more
doaj   +1 more source

Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.

PLoS ONE, 2020
BackgroundA considerable challenge in quantification of the antimalarial piperaquine in plasma is carryover of analyte signal between assays. Current intensive pharmacokinetic studies often rely on the merging of venous and capillary sampling.
Norah Mwebaza, Vincent Cheah, Camilla Forsman, Richard Kajubi, Florence Marzan, Erika Wallender, Grant Dorsey, Philip J Rosenthal, Francesca Aweeka, Liusheng Huang   +9 more
doaj   +1 more source