Results 61 to 70 of about 6,942 (191)

Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

BMC Medicine, 2022
Background Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence of PPQ resistance in Southeast Asia threaten its continued use in Kenya and Africa.
Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M. Akala   +18 more
doaj   +1 more source

A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia. [PDF]

, 2007
OBJECTIVES: To compare the efficacy and tolerability of dihydroartemisinin-piperaquine (DHA-PQP) with that of a 3-day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia.
D. Socheat, Van Herp, M, Nong, S, Goubert, L, Ashley, E A, M. Van Herp, S. Nong, E. A. Ashley, Brockman, A., Uong, S, L. Goubert, Goubert, L., Socheat, D, Van Damme, W., W. Van Damme, Chan, S, Van Herp, M., Uong, S., B. Janssens, S. Chan, A. Brockman, Van Damme, W, Socheat, D., Brockman, A, Ashley, E. A., S. Uong, Janssens, B., Janssens, B, Chan, S.   +28 more
core   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

The pharmaceutical death-ride of dihydroartemisinin

Malaria Journal, 2010
In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies.
Jansen Frans
doaj   +1 more source

Malaria Transmission After Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine: A Randomized Trial [PDF]

The Journal of Infectious Diseases, 2013
Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmission, compared with non-ACTs. It is unclear whether this effect differs between ACTs.A total of 298 children (age, 6 months to 10 years) with uncomplicated falciparum malaria were randomized to artemether-lumefantrine (AL; n = 153) or dihydroartemisinin-piperaquine ...
Sawa, P., Shekalaghe, S., Drakeley, C., Sutherland, C.J., Mweresa, C.K., Baidjoe, A.Y., Manjurano, A., Kavishe, R.A., Beshir, K.B., Yussuf, R.U., Omar, S.A., Hermsen, C.C., Okell, L., Schallig, H.D., Sauerwein, R.W., Hallett, R.L., Bousema, T.   +16 more
openaire   +3 more sources

Effect of dihydroartemisinin/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV. [PDF]

, 2022
BACKGROUND: In sub-Saharan Africa, the burdens of malaria and HIV infections overlap. In settings with moderate-to-high malaria transmission intensity, pregnant women living with HIV (PLWH) require both ART and malaria intermittent preventive treatment ...
Allen, Elizabeth, Ter Kuile, Feiko O., Kapulula, Mayamiko, Maartens, Gary, Phiri, Kamija S., Workman, Lesley, Banda, Clifford G, Munharo, Steven, Barnes, Karen I, Mwapasa, Victor, Ter Kuile, Feiko; id_orcid, Muyaya, Sharon, Barnes, Karen I., Ter Kuile, Feiko O, Nkosi, Dumisile, Phiri, Kamija S, Chirwa, Marumbo, Wiesner, Lubbe, Madanitsa, Mwayiwawo, Banda, Clifford G.   +19 more
core   +1 more source

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Artemisinin derivatives and their partner drugs in artemisinin combination therapies (ACTs) have played a pivotal role in global malaria mortality reduction during the last two decades.
Duangkamon Loesbanluechai, Namfon Kotanan, Cristina de Cozar, Theerarat Kochakarn, Megan R. Ansbro, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Marcus C.S. Lee, Francisco Javier Gamo, Laura Maria Sanz, Thanat Chookajorn, Krittikorn Kümpornsin   +12 more
doaj   +1 more source

Effects of Dihydroartemisinin-Piperaquine Phosphate and Artemether-Lumefantrine on QTc Interval Prolongation [PDF]

Scientific Reports, 2019
AbstractQT/QTc interval prolongation reflects delayed cardiac repolarization which can lead to Torsade de Pointes and sudden death. Many antimalarial drugs prolong QT/QTc interval. However, due to confounding factors in patients with malaria, the precise extent of this effect has been found to be highly variable among studies.
Funck-Brentano, Christian, Bacchieri, Antonella, Valentini, Giovanni, Pace, Silvia, Tommasini, Silva, Voiriot, Pascal, Ubben, David, Duparc, Stephan, Evene, Eric, Felices, Mathieu, Corsi, Marco   +10 more
openaire   +3 more sources

An Efficient, Green Chemical Synthesis of the Malaria\ud Drug, Piperaquine [PDF]

, 2013
To provide a robust, efficient synthesis of the malaria drug piperaquine for potential use in resource-poor settings. We used in-process analytical technologies (IPAT; HPLC) and a program of experiments to develop a synthesis of piperaquine that avoids ...
Fortunak, Joseph MD, Thompson, Keeshaloy, King, Christopher L, Byrn, Stephen R, Dyson, Brandon, Ellison, Tiffany, Conrad, Chelsea, Lee, Mindy, Kulkarni, Amol A, Ekeocha, Zita   +9 more
core  

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source