Results 41 to 50 of about 6,942 (191)

Efficacy of two versus three-day regimens of dihydroartemisinin-piperaquine for uncomplicated malaria in military personnel in northern Cambodia: an open-label randomized trial.

PLoS ONE, 2014
IntroductionEmerging antimalarial drug resistance in mobile populations remains a significant public health concern. We compared two regimens of dihydroartemisinin-piperaquine in military and civilians on the Thai-Cambodian border to evaluate national ...
Chanthap Lon, Jessica E Manning, Pattaraporn Vanachayangkul, Mary So, Darapiseth Sea, Youry Se, Panita Gosi, Charlotte Lanteri, Suwanna Chaorattanakawee, Sabaithip Sriwichai, Soklyda Chann, Worachet Kuntawunginn, Nillawan Buathong, Samon Nou, Douglas S Walsh, Stuart D Tyner, Jonathan J Juliano, Jessica Lin, Michele Spring, Delia Bethell, Jaranit Kaewkungwal, Douglas Tang, Char Meng Chuor, Prom Satharath, David Saunders   +24 more
doaj   +1 more source

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.

PLoS ONE, 2008
BackgroundUganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation for administration with fatty ...
Adoke Yeka, Grant Dorsey, Moses R Kamya, Ambrose Talisuna, Myers Lugemwa, John Bosco Rwakimari, Sarah G Staedke, Philip J Rosenthal, Fred Wabwire-Mangen, Hasifa Bukirwa   +9 more
doaj   +1 more source

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens. [PDF]

, 2015
BACKGROUND: The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and ...
Tamara Clark, Grant Dorsey, Achan, Jane, Dorsey, Grant, Mwangwa, Florence, Kapisi, James, Kamya, Moses, Seyi Soremekun, Moses Kamya, Bigira, Victor, Soremekun, Seyi, Florence Mwangwa, Clark, Tamara, Kinara, Stephen, James Kapisi, Victor Bigira, Stephen Kinara, Jane Achan   +17 more
core   +1 more source

Effectiveness of dihydroartemisinin-piperaquine after 10 years as treatment for vivax malaria in Indonesia

Journal of Infection in Developing Countries, 2023
Introduction: Dihydroartemisin-piperaquine (DHP) is a type of artemisinin-based combination therapy (ACT) that is extensively used in Indonesia as first-line malaria treatment over the past 10 years.
Fanny Arcelia, Ayodhia Pitaloka Pasaribu, Gema Nazri Yanni   +2 more
doaj   +1 more source

Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Emerging Infectious Diseases, 2018
Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 ...
Juliana Inoue, Miguel Silva, Bakary Fofana, Kassim Sanogo, Andreas Mårtensson, Issaka Sagara, Anders Björkman, Maria Isabel Veiga, Pedro Eduardo Ferreira, Abdoulaye Djimde, José Pedro Gil   +10 more
doaj   +1 more source

Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial [PDF]

, 2009
BACKGROUND: Artemisinin combination therapies (ACTs) are currently the preferred option for treating uncomplicated malaria. Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in ...
Corsi Marco, Nambozi Michael, Bassat Quique, Piola, Patrice, Nabasumba, C., Umberto D'Alessandro, Bassat, Q., D'Alessandro Umberto, Halidou Tinto, D’Alessandro, U., Clara Menéndez, Nabasumba Carolyn, Valéa Innocent, Ubben, D., Borrmann Steffen, Mulenga Modest, Corsi, M., Mulenga, Modest, Nambozi, M., Talisuna, A., Tinto, Halidou, Vale´a, I., David Ubben, Innocent Valéa, Sasi Philip, Marco Corsi, Piola Patrice, Bacchieri, Antonella, Sasi, P., Nabasumba, Carolyn, Bacchieri, A., Michael Nambozi, Ambrose Talisuna, Carolyn Nabasumba, Nambozi, Michael, Valéa, Innocent, Philip Sasi, Menéndez, Clara, Talisuna, Ambrose, Menéndez Clara, Patrice Piola, Ubben, David, Sasi, Philip, Antonella Bacchieri, Borrmann, S., Tinto Halidou, Bassat, Quique, D'Alessandro, Umberto, Tinto, H., Mulenga, M., Bacchieri Antonella, Piola, P., Borrmann, Steffen, Corsi, Marco, Talisuna Ambrose, Ubben David, Quique Bassat, Modest Mulenga, Steffen Borrmann, Mene´ndez, C.   +59 more
core   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

Efficacy of antimalarial drugs for treatment of uncomplicated falciparum malaria in Asian region: A network meta-analysis.

PLoS ONE, 2019
BackgroundThe WHO recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria. Hence, monitoring the efficacy of antimalarial drugs is a key component of malaria control and elimination.
Cho Naing, Maxine A Whittaker, Norah Htet Htet, Saint Nway Aye, Joon Wah Mak   +4 more
doaj   +1 more source

Evaluation of a sticky trap for collecting Aedes (Stegomyia) adults in a dengue-endemic area in Thailand. [PDF]

, 2008
Development of new operational techniques for collection and monitoring of adult Stegomyia mosquitoes is considered a pressing need for surveillance and prevention of arboviruses.
Valerio, Laura, Jones, JW, Facchinelli, Luca, Scott, Thomas W, Koenraadt, CJ, Kijchalao, U, della Torre, A, Koenraadt, Constantianus JM, Jones, James W, Valerio, L, Scott, TW, Facchinelli, L, Fanello, C, della Torre, Alessandra, Fanello, Caterina, Kijchalao, Udom   +15 more
core   +1 more source

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.

PLoS Medicine, 2017
BackgroundArtemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia.
Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning   +23 more
doaj   +1 more source