Results 51 to 60 of about 6,942 (191)

Protecting future antimalarials from the trap of resistance: Lessons from artemisinin-based combination therapy (ACT) failures

Journal of Pharmaceutical Analysis, 2021
Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine (DHA-PPQ), Cambodia swapped the first line artemisinin-based combination therapy (ACT) from DHA-PPQ to artesunate-mefloquine given that parasites resistant to ...
Nekpen Erhunse, Dinkar Sahal
doaj   +1 more source

Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam [PDF]

Malaria Journal, 2017
ظهرت المتصورة المنجلية المقاومة للأرتيميسينين في بلدان منطقة الميكونغ الكبرى دون الإقليمية مما يشكل تهديدًا خطيرًا للجهود العالمية للقضاء على الملاريا. كانت علاقة مقاومة الأرتيميسينين بفشل العلاج غير واضحة. في الدراسات السنوية التي أجريت في ثلاث مقاطعات موبوءة بالملاريا في جنوب فيتنام (بينه فوك ونينه ثوان وجيا لاي) بين عامي 2011 و 2015، تم تسجيل 489 ...
Ngo Viet Thanh, Thuy-Nhien Nguyen, Nguyen Thi Kim Tuyen, Nguyen Thanh Tong, Nguyen Thuy Nha-Ca, Le Thanh Dong, Huynh Hong Quang, Jeremy Farrar, Guy Thwaites, Nicholas J. White, Marcel Wolbers, Tran Tinh Hien   +11 more
openaire   +3 more sources

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

Malaria Journal, 2017
Background Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene.
Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth A. Ashley, Arjen M. Dondorp, Nicholas J. White, Dyann Wirth, Rick Fairhurst, Sarah K. Volkman   +17 more
doaj   +1 more source

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

, 2006
In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT).
van Overmeir, C, Karema, Corine, Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., van Doren, W., van Doren, W, Karema, C., Fanello, Caterina I, Fanello, Caterina I., D'Alessandro, Umberto, Van Overmeir, C., Fanello, CI, d' Alessandro, Umberto, van Geertruyden, Jean-Pierre, Ngamije, Daniel, van Overmeir, Chantal, van Doren, Walli, D'Alessandro, U, Karema, C, van Geertruyden, JP, Van Geertruyden, J. P.   +22 more
core   +1 more source

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley   +1 more source

A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan

Malaria Journal, 2012
Background Pregnancy is associated with an increased risk of developing a malaria infection and a higher risk of developing severe malaria. The pharmacokinetic properties of many anti-malarials are also altered during pregnancy, often resulting in a ...
Hoglund Richard M, Adam Ishag, Hanpithakpong Warunee, Ashton Michael, Lindegardh Niklas, Day Nicholas PJ, White Nicholas J, Nosten Francois, Tarning Joel   +8 more
doaj   +1 more source

Dosing table for dihydroartemisinin piperaquine used in Indonesia.

, 2023
Dosing table for dihydroartemisinin piperaquine used in Indonesia.
Nicholas P. Day (12366670), Julie A. Simpson (242873), Ari Satyagraha (16943021), Niamh Meagher (10905688), Mohammad Anwar Hasanzai (16939316), Ayodhia Pitaloka Pasaribu (8842943), Krisin Chand (16939310), Awab Ghulam Rahim (13744507), Naomi Waithira (8188137), Inge Sutanto (391795), Nicholas J. White (35779), J. Kevin Baird (7464932), Ric N. Price (7464974), Walter R. J. Taylor (8537583), Tamiru S. Degaga (16943024), Adugna Woyessa (802684), Nguyen Thi Tuyet-Trinh (16943030), Nguyen Hoang Chau (13744510), Arjen Dondorp (229103), Benedikt Ley (148722), Asrat Hailu (59005), Ashenafi Assefa (776696), Lenny L. Ekawati (14241842), Mehul Dhorda (351592), Germana Bancone (34875), Lorenz von Seidlein (45473), Kamala Thriemer (148725), Mohammad Nader Naddim (16939313), Ngo Viet Thanh (16943027)   +28 more
core   +1 more source

Development of a Disease‐Specific Virtual Malaria Population for Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Malaria remains a major global health challenge, with an urgent need for new therapies to combat the evolving resistance to anti‐malarial treatments. Physiologically‐based pharmacokinetic (PBPK) modeling offers a promising approach to accurately predict PK, optimize dosing strategies, reduce development time and cost, and de‐risk the ...
Junjie Ding, Qi Pei, Richard M. Hoglund, Joel Tarning   +3 more
wiley   +1 more source

Therapeutic Efficacy and Safety of Dihydroartemisinin-Piperaquine (DP) for the Treatment of Uncomplicated Plasmodium Vivax Malaria: A Single Center Study

JLUMHS, 2017
BACKGROUND: Ninety-five millions of Pakistan's 161 million people, roughly 60% of Pakistan’s population live in malaria endemic regions. Despite a well-established malaria control programme, 500,000 malaria infections and 50,000 malaria-attributable ...
Salma Shaikh, Imran Ahmed, Sikander Munir Memon , Abdul Saleem, Hafeezullah Memon, Ayaz Babar   +5 more
doaj   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source