Results 21 to 30 of about 6,942 (191)

Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia. [PDF]

J Trop Med, 2022
After decades of successful artemisinin regimen in combating malaria, its effectiveness has decreased since parasite resistance to the treatment regimen has begun to appear. Adherence to artemisinin combination therapy (ACT) in a population is considered to be the key factor contributing to such resistance phenomenon.
Chakim I, Pumpaibool T, Sayono, Fauzi ER.   +3 more
europepmc   +4 more sources

Stability Studies of Reconstituted Dihydroartemisinin–Piperaquine Paediatric Formulation

Journal of Chemistry
This study investigated the stability of a paediatric dihydroartemisinin (DHA)–piperaquine (PPQ) powder for reconstitution (DHP) available in Ghana, addressing concerns about nonadherence to recommended refrigeration and the use of various water sources ...
Kingsley Amponsah Nti, James Oppong-Kyekyeku, Samuel Oppong Bekoe, John Nii Adotey Addotey   +3 more
doaj   +2 more sources

The Impact of <i>pfmdr1</i> Gene Copy Number on the Efficacy of Dihydroartemisinin-Piperaquine in Treating Malaria in West Sumba and Kupang Districts, East Nusa Tenggara, Indonesia. [PDF]

J Parasitol Res
The efficacy of antimalarial treatment, particularly artemisinin‐based combination therapy (ACT), continues to face persistent threats due to the development of drug resistance in Plasmodium falciparum. Although artemisinin derivatives remain effective, ACT regimen failure often results from decreased efficacy of the companion drug.
Irdayanti I, Aswad H, Asih PBS, Rozi IE, Herdiana H, Diptyanusa A, Prameswari HD, Yusuf Y, Bahrani B, Hidayah N, Artika IM, Syafruddin D.   +11 more
europepmc   +2 more sources

Pilot study: bioequivalence of dihydroartemisinin in dihydroartemisinin-piperaquine tablet generic formulation in healthy Indonesian volunteers. [PDF]

Nagoya J Med Sci, 2023
Bioequivalence test should be carried out for copy medicine, including dihydroartemisinin-piperaquine (DHP), which is used to treat critical diseases requiring medication.
Isnawati A, Gitawati R, Alegantina S, Setyorini HA.   +3 more
europepmc   +2 more sources

Correction: Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia. [PDF]

Malar J, 2023
Correction to: "Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection ...
Assefa A, Mohammed H, Anand A, Abera A, Sime H, Minta AA, Tadesse M, Tadesse Y, Girma S, Bekele W, Etana K, Alemayehu BH, Teka H, Dilu D, Haile M, Solomon H, Moriarty LF, Zhou Z, Svigel SS, Ezema B, Tasew G, Woyessa A, Hwang J, Murphy M.   +23 more
europepmc   +2 more sources

Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa [PDF]

, 2001
We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non-panmictic molecular forms,
Akogbeto, M, della Torre, A, Dossou-Yovo, J, Coluzzi, M, Fanello, C, Favia, G, Petrarca, V   +6 more
core   +5 more sources

Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial

The Lancet Microbe, 2022
Summary: Background: Pyronaridine–artesunate is the most recently licensed artemisinin-based combination therapy. WHO has recommended that a single low dose of primaquine could be added to artemisinin-based combination therapies to reduce Plasmodium ...
William Stone, PhD, Almahamoudou Mahamar, MD, Koualy Sanogo, MD, Youssouf Sinaba, MD, Sidi M Niambele, PharmD, Adama Sacko, MS, Sekouba Keita, MS, Ahamadou Youssouf, PharmD, Makonon Diallo, MD, Harouna M Soumare, PharmD, Harparkash Kaur, PhD, Kjerstin Lanke, BSc, Rob ter Heine, PhD, John Bradley, PhD, Djibrilla Issiaka, MD, Halimatou Diawara, MD, Sekou F Traore, PhD, Teun Bousema, ProfPhD, Chris Drakeley, ProfPhD, Alassane Dicko, ProfMD   +19 more
doaj   +1 more source

Therapeutic response to artemisinin combination therapies among individuals with Plasmodium falciparum single infection vs mixed Plasmodium species infections: a retrospective posthoc analysis in Kisumu County, western Kenya

International Journal of Infectious Diseases, 2023
Objectives: This study examined the treatment response of mixed vs single-species Plasmodium falciparum infections to artemisinin-based combination therapies (ACTs).
Gladys C. Chemwor, Ben M. Andagalu, Irene A. Onyango, Benjamin H. Opot, Raphael O. Okoth, Redemptah A. Yedah, Jackline A. Juma, Edwin W. Mwakio, Dancan M. Wakoli, Joseph G. Amwoma, Agnes C. Cheruiyot, Dennis W. Juma, Bernhards R. Ogutu, Timothy E. Egbo, Eric C. Garges, Amanda L. Roth, Edwin Kamau, Oliver J. Watson, Hoseah M. Akala   +18 more
doaj   +1 more source

Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis.

PLoS ONE, 2022
BackgroundSub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the global burden of malaria.
Karol Marwa, Anthony Kapesa, Vito Baraka, Evelyne Konje, Benson Kidenya, Jackson Mukonzo, Erasmus Kamugisha, Gote Swedberg   +7 more
doaj   +2 more sources

Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Malaria Journal, 2019
Mutations in the propeller domain of Plasmodium falciparum kelch 13 (Pfk13) gene are associated with artemisinin resistance in Southeast Asia. Artemisinin resistance is defined by increased ring survival rate and delayed parasite clearance half-life in ...
Francis Foguim Tsombeng, Mathieu Gendrot, Marie Gladys Robert, Marylin Madamet, Bruno Pradines   +4 more
doaj   +1 more source