Results 161 to 170 of about 11,186 (206)

A dynamic pharmacometric framework defining the relationship between ivermectin exposure and mosquito lethality

Hoglund RM, Kobylinski KC, Jittamala P, Hanboonkunupakarn B, Wamaket N, Sriwichai P, Phasomkusolsil S, White NJ, Day NP, Tarning J.   +9 more
europepmc   +1 more source

Effect of malaria chemoprevention for school-age children across transmission archetypes: a modelling study.

Lancet Glob Health
Suresh J, Zimmermann M, Maiteki C, Stahlfeld A, Pratt A, Mathanga DP, Staedke SG, Laufer MK, Drakeley C, Bever C, Cohee LM.   +10 more
europepmc   +1 more source

Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity

ChemMedChem, 2019
AbstractA series of hybrid compounds based on natural products—bile acids and dihydroartemisinin—were prepared by different synthetic methodologies and investigated for their in vitro biological activity against HL‐60 leukemia and HepG2 hepatocellular carcinoma cell lines.
Daniela Perrone, Maria Luisa Navacchia, Elena Marchesi   +2 more
exaly   +7 more sources

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PEGylated-Paclitaxel and Dihydroartemisinin Nanoparticles for Simultaneously Delivering Paclitaxel and Dihydroartemisinin to Colorectal Cancer

Pharmaceutical Research, 2020
Development of a nanoplatform constructed by the PEG-dual drug conjugation for co-delivery of paclitaxel (PTX) and Dihydroartemisinin (DHA) to the tumor.PEG was conjugated with PTX and DHA to form PTX-PEG-DHA complex as a nanocarrier. The PTX and DHA were co-encapsulated in PTX-PEG-DHA nanoparticles (PD@PPD NPs) by the emulsion evaporation method.
Cao Dai Phung, Chien Nguyen, Jong Oh Kim   +2 more
exaly   +3 more sources

Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone

Archives of Pharmacal Research, 2008
In the present study the physicochemical characteristics of dihydroartemisinin, polyvinylpyrrolidone and their solid dispersions were evaluated at various proportions of drug and polyvinylpyrrolidone. These properties were investigated with X-ray diffraction, fourier transform infrared spectrophotometry, differential scanning calorimetry, equilibrium ...
Muhammad Tayyab Ansari
exaly   +4 more sources

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells [PDF]

Frontiers in Pharmacology, 2020
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults and accounts for 85–90% of all primary liver cancer. Based on the estimation by the International Agency for Research on Cancer in 2018, liver cancer is the fourth leading cause of cancer death globally.
Daniela Perrone, Maria Luisa Navacchia, Elena Marchesi   +2 more
exaly   +5 more sources

A new decomposition product of dihydroartemisinin

Die Pharmazie, 2007
After prolonged storage, samples of dihydroartemisinin were found to contain a decomposition product with a molecular weight of 238, as evidenced by MS analysis, the formation of which was accelerated by heating at 60 °C for several days. This decomposition product was isolated and identified as 2-(3-oxobutyl)-3-methyl-6-(2-propanal)-cyclohexanon ...
Dhooghe, L., van Miert, S., Jansen, H., Vlietinck, A., Pieters, L.   +4 more
openaire   +3 more sources

Effects of artesunate, dihydroartemisinin, and an artesunate-dihydroartemisinin combination against Toxoplasma gondii.

The American journal of tropical medicine and hygiene, 2000
The effect of artesunate and its metabolite dihydroartemisinin against the cerebral cysts of Toxoplasma gondii was studied. In vitro experiments were performed with the THP-1 cell line and showed an inhibition of parasite growth of approximately 70% with 0.1-0.5 microg/ml of dihydroartemisinin for 96 hr. However, with artesunate, dihydroartemisinin, or
M E, Sarciron, C, Saccharin, A F, Petavy, F, Peyron   +3 more
openaire   +2 more sources