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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014
The UV-vis absorption, steady state/time resolved fluorescence spectroscopy and synchronous fluorescence, circular dichroism (CD) spectroscopy are used to investigate the interaction mechanisms of dihydroartemisinin (DHA) and 9-hydroxy-dihydroartemisinin (9-OH DHA), respectively.
Mengsi, Xiao +9 more
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The UV-vis absorption, steady state/time resolved fluorescence spectroscopy and synchronous fluorescence, circular dichroism (CD) spectroscopy are used to investigate the interaction mechanisms of dihydroartemisinin (DHA) and 9-hydroxy-dihydroartemisinin (9-OH DHA), respectively.
Mengsi, Xiao +9 more
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Pharmacokinetics of Dihydroartemisinin in a Murine Malaria Model
The American Journal of Tropical Medicine and Hygiene, 2008Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls.
Batty, Kevin +3 more
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Antimalarial dihydroartemisinin also inhibits angiogenesis
Cancer Chemotherapy and Pharmacology, 2004Dihydroartemisinin, a more water-soluble metabolite of artemisinin derivatives, is a safe and most effective antimalarial analog of artemisinin. In the present study, we investigated the antiangiogenic activity of dihydroartemisinin in vitro and in vivo, and investigated dihydroartemisinin-induced apoptosis in human umbilical vein endothelial cells ...
Huan-Huan, Chen +3 more
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การประเมินความจำเพาะของวิธีวิเคราะห์ตามเภสัชตำรับของยา Dihydroartemisinin
Dihydroartemisinin (DHA) is an Artemisinin derivative used in combination with Piperaquine as antimalarial regimen which is actively used in Eastern Thailand, Cambodia, and Vietnam. Based on several labile functional groups on DHA structure, such as peroxide and hemiacetal, the drug has been reported to have stability problem and can be degraded viaopenaire +1 more source