Results 171 to 180 of about 217,358 (308)

Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning. [PDF]

Sci Adv
Romanowicz KJ, Resnick C, Hinton SR, Plesa C.   +3 more
europepmc   +1 more source

Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage. [PDF]

Front Mol Neurosci, 2023
Miao SH, Gao SQ, Li HX, Zhuang YS, Wang X, Li T, Gao CC, Han YL, Qiu JY, Zhou ML.   +9 more
europepmc   +1 more source

Design, Synthesis, and Antifolate Activity of New Analogues of Piritrexim and Other Diaminopyrimidine Dihydrofolate Reductase Inhibitors with ω-Carboxyalkoxy or ω-Carboxy-1-alkynyl Substitution in the Side Chain

, 2005
David C. Chan, Hongning Fu, Ronald A. Forsch, Sherry F. Queener, A. Rosowsky   +4 more
openalex   +1 more source

Peer Review #3 of "A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase (v0.1)"

, 2021

openalex   +1 more source

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Proceedings of the National Academy of Sciences of the United States of America, 2013
Louis Y. P. Luk, J. Javier Ruiz-Pernía, W. Dawson, Maite Roca, E. Loveridge, D. Glowacki, J. Harvey, A. Mulholland, I. Tuñón, V. Moliner, R. Allemann   +10 more
semanticscholar   +1 more source

Identification of potential inhibitors of dihydrofolate reductase (DHFR) through blocking the folate biosynthetic pathway of <i>Mycobacterium tuberculosis</i> utilizing structure-based virtual screening. [PDF]

RSC Adv
Halder SK, Sultana A, Ahmad I, Rafi MO, Sultana I, Elma F, Ananna IJ, Patel H, Himel MK, Shil A.   +9 more
europepmc   +1 more source

Comparison of the Role of Protein Dynamics in Catalysis by Dihydrofolate Reductase from E. coli and H. sapiens. [PDF]

J Phys Chem B, 2022
Andrews BA, Dyer RB.
europepmc   +1 more source

Design, Synthesis, and Biological Activities of Classical N-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-l-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents

, 2003
Aleem Gangjee, Jianming Yu, Roy L. Kisliuk, William H. Haile, G. Sobrero, John J. McGuire   +5 more
openalex   +1 more source

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

Proceedings of the National Academy of Sciences of the United States of America, 2013
C. Liu, Philip Hanoian, J. French, Tom H. Pringle, S. Hammes‐Schiffer, S. Benkovic   +5 more
semanticscholar   +1 more source

Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase. [PDF]

J Phys Chem B
Kalmer TL, Ancajas CMF, Cohen CI, McDaniel JM, Oyedele AS, Thirman HL, Walker AS.   +6 more
europepmc   +1 more source