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Inhibitors of Dihydrofolate Reductase
1983Methotrexate (1b), which remains the single most important antifol anticancer agent after 30 years of clinical use, owes its activity to its stoichiometric inhibition of the enzyme dihydrofolate reductase (EC 1. 5. 1. 3.). Methotrexate was introduced as an antileukaemic agent 10 years before dihydrofolate reductase was demonstrated to be its prime ...
B. Roth, E. Bliss, C. R. Beddell
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Dihydrofolate reductase inhibitors: patent landscape and phases of clinical development (2001–2021)
Expert Opinion on Therapeutic Patents, 2022Dr. kavita bhagat +2 more
exaly
Dihydrofolate Reductase Inhibitors
1984While exploring structural variations of anilinopyrimidines with antimalarial activity, a group at Imperial Chemical Industries found that certain biguanides synthesised as ring-opened analogues possessed good activity against Plasmodium gallinaceum infections in chicks (Curd et al. 1945).
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An Insight into Synthetic Strategies and Recent Developments of Dihydrofolate Reductase Inhibitors
ChemistrySelect, 2021Pooja A Chawla
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Multiple forms of dihydrofolate reductase
Biochemical and Biophysical Research Communications, 1968G P, Mell +3 more
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