Results 161 to 170 of about 45,192 (224)

Solution Ionic Strength Can Modulate Functional Loop Conformations in E. coli Dihydrofolate Reductase. [PDF]

J Phys Chem B
Babu CS, Chen JY, Lim C.
europepmc   +1 more source

Synthesis, in vitro biological evaluation and in silico studies of novel pyrrolidine derived thiosemicarbazones as dihydrofolate reductase inhibitors. [PDF]

RSC Adv
Aftab H, Ullah S, Khan A, Al-Rashida M, Islam T, Alshammari A, Albekairi NA, Taslimi P, Al-Harrasi A, Shafiq Z, Alghamdi S.   +10 more
europepmc   +1 more source

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate. [PDF]

PLoS Genet
Rouleau FD, Dubé AK, Gagnon-Arsenault I, Dibyachintan S, Pageau A, Després PC, Lagüe P, Landry CR.   +7 more
europepmc   +1 more source

Synthesis, molecular docking study and biological evaluation of new pyrrole scaffolds as potential antitubercular agents for dual targeting of enoyl ACP reductase and dihydrofolate reductase. [PDF]

PLoS One
Mahnashi MH, Avunoori S, Gopi S, Shaikh IA, Saif A, Bantun F, Faidah HS, Alhadi AA, Alshehri JH, Alharbi AA, S R PK, Joshi SD.   +11 more
europepmc   +1 more source

Studies on Dihydrofolic Reductase

Journal of Biological Chemistry, 1966
Bernard T. Kaufman, Rita C. Gardiner
openaire   +1 more source

The Function of the Active Site Glutamate in Human Dihydrofolate Reductase

Pteridines, 1991
Blakley R. L., Appleman J. R., Tsay J. T., Beard W. A., Freisheim J. H., Ayling J. E., Jablonsky M. J.   +6 more
doaj   +1 more source

TaqMan-quantitative PCR assays applied in Neospora caninum knock-outs generated through CRISPR-Cas9 allow to determine the copy numbers of integrated dihydrofolate reductase-thymidylate synthase drug selectable markers. [PDF]

Front Cell Infect Microbiol
Rico-San Román L, Hänggeli KPA, Hemphill A, Horcajo P, Collantes-Fernández E, Ortega-Mora LM, Boubaker G.   +6 more
europepmc   +1 more source

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Dismutation of dihydrofolate by dihydrofolate reductase

Biochemistry, 1984
Degradation of 7,8-dihydrofolate (H2folate) in the presence of dihydrofolate reductase (DHFR) has been shown due not to an oxygenase activity of the reductase as previously reported but to dismutation of H2folate to folate and 5,6,7,8-tetrahydrofolate (H4folate). The reaction can be followed spectrophotometrically or by analysis of the reaction mixture
R L, Blakley, L, Cocco
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Dihydrofolic Acid Reductase

Nature, 1958
THE enzymatic reduction of dihydrofolic acid (FH2) to tetrahydrofolic acid (FH4) has been reported by several investigators1–3. Futterman1 noted that dihydrofolic acid was reduced by chicken liver extracts when either reduced di- or tri-phospho-pyridine nucleotide served as the co-factor. We have found that the rate of reduction of dihydrofolic acid by
J M, PETERS, D M, GREENBERG
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How Dihydrofolate Reductase Facilitates Protonation of Dihydrofolate

Journal of the American Chemical Society, 2003
Dihydrofolate Reductase (DHFR) catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate. On the basis of 10-12.5 ns molecular dynamics simulations of two conformations (closed and occluded) of the ternary DHFR/NADPH/H2F complex from Escherichia coli and a free energy perturbation approach, we have calculated the pKa value for the N5 atom in ...
Thomas H, Rod, Charles L, Brooks
openaire   +2 more sources