Results 211 to 220 of about 217,358 (308)

In search of dihydrofolate reductase [PDF]

Protein Science, 1996
openaire   +2 more sources

Interactions of Methotrexate, Trimetrexate and Piritrexim with Human and L. casei Dihydrofolate Reductases — Steady State Inhibition Constants and Dissociation Rates

, 1991
Peter F. Nixon, Mark Waltham
openalex   +2 more sources

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

Proceedings of the National Academy of Sciences of the United States of America, 2011
Andrew J. Adamczyk, Jie Cao, S. C. Kamerlin, A. Warshel   +3 more
semanticscholar   +1 more source

Benzamide Trimethoprim Derivatives as Human Dihydrofolate Reductase Inhibitors-Molecular Modeling and In Vitro Activity Study. [PDF]

Biomedicines
Drozdowska D, Wróbel-Tałałaj A, Parzych C, Ratkiewicz A.   +3 more
europepmc   +1 more source

Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus. [PDF]

Antimicrob Agents Chemother
Aragaw WW, Negatu DA, Bungard CJ, Dartois VA, Marrouni AE, Nickbarg EB, Olsen DB, Warrass R, Dick T.   +8 more
europepmc   +1 more source

Probing the Active Site of Candida glabrata Dihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

, 2008
Jieying Liu, David B. Bolstad, Adrienne E. Smith, Nigel D. Priestley, Dennis L. Wright, Amy C. Anderson   +5 more
openalex   +1 more source

Solution Ionic Strength Can Modulate Functional Loop Conformations in E. coli Dihydrofolate Reductase. [PDF]

J Phys Chem B
Babu CS, Chen JY, Lim C.
europepmc   +1 more source

A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials

, 2004
França Tanos C. C., Medeiros André L. R. de, Santos Edison C. P. dos, Santos-Filho Osvaldo A., Figueroa-Villar José D.   +4 more
openalex   +1 more source

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

, 1997
Worachart Sirawaraporn, Tanajit Sathitkul, Rachada Sirawaraporn, Yongyuth Yuthavong, Daniel V. Santi   +4 more
openalex   +2 more sources

Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes

Proceedings of the National Academy of Sciences of the United States of America, 2011
S. Mharakurwa, Taida Kumwenda, M. Mkulama, Mulenga Musapa, Sandra Chishimba, C. Shiff, D. Sullivan, P. Thuma, Kun Liu, P. Agre   +9 more
semanticscholar   +1 more source