Results 251 to 260 of about 217,358 (308)

The mammalian dihydrofolate reductase locus

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990
Synthese de resultats relatifs au gene de la dihydrofolate reductase, en particulier: expression et replication, structure de la chromatine et organisation nucleaire, mutation, reparation et recombinaison du gene; role de ce gene dans la division des cellules tumorales et applications en chimiotherapie et genie ...
J L, Hamlin, C, Ma
openaire   +2 more sources

Directed Mutagenesis of Dihydrofolate Reductase

Science, 1983
Three mutations of the enzyme dihydrofolate reductase were constructed by oligonucleotide-directed mutagenesis of the cloned Escherichia coli gene. The mutations—at residue 27, aspartic acid replaced with asparagine; at residue 39, proline replaced with cysteine; and at residue 95, glycine replaced with alanine—were
Villafranca, Jesus E., Howell, Elizabeth E., Voet, Donald H., Strobel, Marjorie C., Ogden, Richard C., Abelson, John N., Kraut, Joseph   +6 more
openaire   +3 more sources

Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings

Nature Chemistry, 2020
N. S. Galenkamp, Annemie Biesemans, G. Maglia   +2 more
semanticscholar   +1 more source

Dihydrofolate reductase inhibitors for use as antimicrobial agents.

European journal of medicinal chemistry, 2020
Juan He, Wenlian Qiao, Qi An, Tao Yang, Youfu Luo   +4 more
semanticscholar   +1 more source

Dihydrofolate Reductase Inhibitors

1984
While exploring structural variations of anilinopyrimidines with antimalarial activity, a group at Imperial Chemical Industries found that certain biguanides synthesised as ring-opened analogues possessed good activity against Plasmodium gallinaceum infections in chicks (Curd et al. 1945).
openaire   +1 more source

Dihydrofolate reductase

Journal of Molecular Biology, 1986
S.J. Hammond, B. Birdsall, M.S. Searle, G.C.K. Roberts, J. Feeney   +4 more
openaire   +1 more source

Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase.

Journal of Medicinal Chemistry, 2017
H. Ng, Xiang Ma, Eng-Hui Chew, W. Chui
semanticscholar   +1 more source

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system

Proteins: Structure, Function, and Bioinformatics, 1988
P. Dauber-Osguthorpe, V. Roberts, D. Osguthorpe, Jon Wolff, Moniqe Genest, A. Hagler   +5 more
semanticscholar   +1 more source

Triazine-benzimidazole hybrids: anticancer activity, DNA interaction and dihydrofolate reductase inhibitors.

Bioorganic & Medicinal Chemistry, 2015
P. Singla, Vijay Luxami, Kamaldeep Paul
semanticscholar   +1 more source

Ampere-level current density ammonia electrochemical synthesis using CuCo nanosheets simulating nitrite reductase bifunctional nature

Nature Communications, 2022
, , Yao-Yin Lou
exaly