Results 31 to 40 of about 48,162 (258)

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies

Chempublish Journal, 2023
Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population.
Muhammad Fikriansyah, Nelson, Madyawati Latief, Indra Lasmana Tarigan   +3 more
doaj   +1 more source

Modeling Dihydrofolate Reductase

The FASEB Journal, 2010
Dihydrofolate reductase (DHFR) is a ubiquitous enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is crucial for purine and thymidylate synthesis, precursors to DNA and RNA. Inhibition of DHFR leads to cessation of cell proliferation because the cell is unable to build DNA and RNA.
Ben Rangel, Guataum Soundarajaran, Colby Ryan, Maddy Jennewein, Kenny Bitar, Gira Bhabha, Amanda Worthen, Susan Moerder   +7 more
openaire   +2 more sources

Self-organizing Neural Networks for Modeling Robust 3D and 4D QSAR: Application to Dihydrofolate Reductase Inhibitors

Molecules, 2004
We have used SOM and grid 3D and 4D QSAR schemes for modeling the activity of a series of dihydrofolate reductase inhibitors. Careful analysis of the performance and external predictivities proves that this method can provide an efficient inhibition ...
Tomasz Magdziarz, Rafal Gieleciak, Andrzej Bak, Jaroslaw Polanski   +3 more
doaj   +1 more source

The requirement of matrix ATP for the import of precursor proteins into the mitochondrial matrix and intermembrane space [PDF]

, 1994
The role of ATP in the matrix for the import of precursor proteins into the various mitochondrial subcompartments was investigated by studying protein translocation at experimentally defined ATP levels.
Gruhler, Albrecht, Guiard, Bernard, Klei, Ida J. van der, Koll, Hans, Neupert, Walter, Stuart, Rosemary A.   +5 more
core   +4 more sources

Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays

Molecules, 2019
Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates.
Magambo Phillip Kimuda, Dustin Laming, Heinrich C. Hoppe, Özlem Tastan Bishop   +3 more
doaj   +1 more source

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

PLoS Neglected Tropical Diseases, 2021
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by
Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette   +2 more
doaj   +1 more source

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

Frontiers in Pharmacology, 2022
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties.
Sadhna Aggarwal, Kanchan Bhadana, Baldeep Singh, Meenakshi Rawat, Taj Mohammad, Lamya Ahmed Al-Keridis, Nawaf Alshammari, Md. Imtaiyaz Hassan, Satya N. Das   +8 more
doaj   +1 more source

Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda [PDF]

, 2014
Dihydrofolate reductase (DHFR) is often used as a model system to study the relation between protein dynamics and catalysis. We have studied a number of variants of the cold-adapted DHFR from Moritella profunda (MpDHFR), in which the catalytically ...
Adamczyk A. J., Agarwal P. K., Allemann R. K., Bhabha G., Blakley R. L., Boehr D. D., Cameron C. E., Cayley P. J., E. Joel Loveridge, Enas M. Behiry, Evans R. M., Fan Y., Fierke C. A., Fuhrmann M., Gekko K., Gekko K., Guo J., Hammes-Schiffer S., Hay S., Jiannan Guo, Loveridge E. J., Loveridge E. J., Loveridge E. J., Loveridge E. J., Luk L. Y. P., Mauldin R. V., Mauldin R. V., Miller G. P., Oyeyemi O. A., Rajagopalan P. T. R., Rhiannon M. Evans, Rod T. H., Rudolf K. Allemann, Ruiz-Pernia J. J., Sawaya M. R., Stone S. R., Swanwick R. S., Swanwick R. S., Thorpe I. F., Venkitakrishnan R. P., Watney J. B., Xu Y.   +41 more
core   +1 more source

CoMFA and CoMSIA Analyses of Pneumocystis carinii Dihydrofolate Reductase, Toxoplasma gondii Dihydrofolate Reductase, and Rat Liver Dihydrofolate Reductase [PDF]

Journal of Medicinal Chemistry, 2005
In a continuing effort to develop potent and selective dihydrofolate reductase (DHFR) inhibitors against opportunistic pathogens, we developed three-dimensional quantitative structure-activity relationship (3D QSAR) models for the inhibitory activity against Pneumocystis carinii (pc) DHFR, Toxoplasma gondii (tg) DHFR, and rat liver DHFR, using a data ...
Xin Lin, Aleem Gangjee
openaire   +3 more sources

Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

BMC Chemistry, 2019
Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR)
Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed   +3 more
doaj   +1 more source