Results 41 to 50 of about 217,358 (308)

Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]

, 2016
Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F., Forster, Victoria J., Halsey, Christina, Mair, Shona, Skinner, Roderick, van Delft, Frederik W.   +5 more
core   +2 more sources

Self-organizing Neural Networks for Modeling Robust 3D and 4D QSAR: Application to Dihydrofolate Reductase Inhibitors

Molecules, 2004
We have used SOM and grid 3D and 4D QSAR schemes for modeling the activity of a series of dihydrofolate reductase inhibitors. Careful analysis of the performance and external predictivities proves that this method can provide an efficient inhibition ...
Tomasz Magdziarz, Rafal Gieleciak, Andrzej Bak, Jaroslaw Polanski   +3 more
doaj   +1 more source

Loop Interactions during Catalysis by Dihydrofolate Reductase fromMoritella profunda [PDF]

, 2014
Dihydrofolate reductase (DHFR) is often used as a model system to study the relation between protein dynamics and catalysis. We have studied a number of variants of the cold-adapted DHFR from Moritella profunda (MpDHFR), in which the catalytically ...
Adamczyk A. J., Agarwal P. K., Allemann R. K., Bhabha G., Blakley R. L., Boehr D. D., Cameron C. E., Cayley P. J., E. Joel Loveridge, Enas M. Behiry, Evans R. M., Fan Y., Fierke C. A., Fuhrmann M., Gekko K., Gekko K., Guo J., Hammes-Schiffer S., Hay S., Jiannan Guo, Loveridge E. J., Loveridge E. J., Loveridge E. J., Loveridge E. J., Luk L. Y. P., Mauldin R. V., Mauldin R. V., Miller G. P., Oyeyemi O. A., Rajagopalan P. T. R., Rhiannon M. Evans, Rod T. H., Rudolf K. Allemann, Ruiz-Pernia J. J., Sawaya M. R., Stone S. R., Swanwick R. S., Swanwick R. S., Thorpe I. F., Venkitakrishnan R. P., Watney J. B., Xu Y.   +41 more
core   +1 more source

Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays

Molecules, 2019
Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates.
Magambo Phillip Kimuda, Dustin Laming, Heinrich C. Hoppe, Özlem Tastan Bishop   +3 more
doaj   +1 more source

A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]

, 2018
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI, Cowan, Don A, Makhalanyane, Thulani P, Pierneef, Rian, Van de Peer, Yves, Van Goethem, Marc W   +5 more
core   +2 more sources

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

PLoS ONE, 2015
The lack of success in target-based screening approaches to the discovery of antibacterial agents has led to reemergence of phenotypic screening as a successful approach of identifying bioactive, antibacterial compounds.
Grace Mugumbate, Katherine A Abrahams, Jonathan A. G. Cox, G. Papadatos, G. V. van Westen, J. Lelièvre, S. Calus, N. Loman, Lluís Ballell, David Barros, John P. Overington, G. Besra   +11 more
semanticscholar   +1 more source

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

Frontiers in Pharmacology, 2022
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties.
Sadhna Aggarwal, Kanchan Bhadana, Baldeep Singh, Meenakshi Rawat, Taj Mohammad, Lamya Ahmed Al-Keridis, Nawaf Alshammari, Md. Imtaiyaz Hassan, Satya N. Das   +8 more
doaj   +1 more source

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Cell Reports, 2019
Summary: Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others.
Andrew F. Schober, Andrew D. Mathis, Christine Ingle, Junyoung O. Park, Li Chen, Joshua D. Rabinowitz, Ivan Junier, Olivier Rivoire, Kimberly A. Reynolds   +8 more
doaj   +1 more source

A silent sulfonamide-resistant microbial world: The curious case of missing DHPS in candidate phyla radiation

Journal of Global Antimicrobial Resistance
Candidate phyla radiation (CPR) microbes exhibit minimal genomes, episymbiotic/parasitic lifestyles, and metabolic dependencies on host cells. In this study, we look for the presence of dihydropteroate synthase (DHPS) and dihydrofolate reductase, key ...
Riyad Razzouk, Adel Azour, Jean-Marc Rolain, Fadi Bittar   +3 more
doaj   +1 more source

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

PLoS Neglected Tropical Diseases, 2021
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by
Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette   +2 more
doaj   +1 more source