Results 61 to 70 of about 23,665 (170)

Review on benzothiazole as a privileged nucleus for Plasmodium DHFR inhibition with structure guided comprehensive analysis

Discover Chemistry
Malaria continues to be a major global health concern as Plasmodium falciparum became resistant to current drugs that target dihydrofolate reductase (DHFR).
Khyatirupa Sarma, Nasreen Ahmed, Zartaj Washmin Banu, Lima Patowary, Dhrubajyoti Gogoi, Nongmaithem Binita Devi, Jun Moni Kalita   +6 more
doaj   +1 more source

Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

Redox Biology, 2019
Hypertension and abdominal aortic aneurysm (AAA) are severe cardiovascular diseases with incompletely defined molecular mechanisms. In the current study we generated dihydrofolate reductase (DHFR) knockout mice for the first time to examine its potential
Qiang Li, Ji Youn Youn, Kin Lung Siu, Priya Murugesan, Yixuan Zhang, Hua Cai   +5 more
doaj   +1 more source

New Insights Into the Phytochemical Composition and Biological Potential of Leaf Extracts From Algerian Autochthonous Vitis vinifera L.

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Phenolic‐rich extracts from five indigenous Algerian Vitis vinifera leaf cultivars were characterized by LC–MS and evaluated for antioxidant, antidiabetic, antibacterial, and molecular docking activities. The Azorith‐fereinguel cultivar showed superior bioactivity, attributed mainly to isoquercitrin, hesperidin, and rutin.
Radhia Belmanaa, Azzeddine Zeraib, Ziane Laiadi, Ahmed Simozrag, Khadra Afaf Bendrihem, Ayomide Victor Atoki, Mohammed Messaoudi   +6 more
wiley   +1 more source

NOX isoforms in the development of abdominal aortic aneurysm

Redox Biology, 2017
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease.
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai   +6 more
doaj   +1 more source

Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 1061-1069, August 2026.
Abstract Objective Methotrexate is widely used to treat ectopic pregnancy (EP). Concerns about its teratogenicity have led to uncertainty regarding the optimal interval before attempting conception. Guidelines recommend a 3‐month washout period, while the manufacturer advises 6 months. Evidence on the safety of early conception is limited.
Bar Rosh, Joul Hadad, Naomi Gronich
wiley   +1 more source

Methotrexate Alters Nrf2/HO‐1 Protein Expression and Intrinsic Apoptosis‐Associated Protein Responses in OVCAR‐3 Ovarian Cancer Cells: Differential Modulation by Antioxidant Compounds

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Methotrexate (MTX) altered oxidative stress parameters, reduced Nrf2 and HO‐1 protein expression, increased intrinsic apoptosis‐associated protein markers, and decreased cell viability in OVCAR‐3 cells. Antioxidant co‐treatment partially modulated these protein responses and oxidative stress parameters.
Oya Korkmaz
wiley   +1 more source

Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase

Molecular Therapy: Methods & Clinical Development, 2018
Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater control over transgene integration site, copy number, and expression—significant advantages over traditional vector-mediated gene therapy with random genome ...
Biswajit Paul, Guillermo S. Romano Ibarra, Nicholas Hubbard, Teresa Einhaus, Alexander Astrakhan, David J. Rawlings, Hans-Peter Kiem, Christopher W. Peterson   +7 more
doaj   +1 more source

SNHG15 Positively Regulates Influenza Virus Infection Through Its Association With miR‐153 and RABL2A

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Influenza viruses cause seasonal epidemics, and current vaccines do not fully protect against them. This study focuses on long non‐coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in various biological processes. We identified 17 lncRNAs altered by the influenza virus.
Samuel Pushparaj, Kishore Vaddadi, Chaoqun Huang, Yurong Liang, Dao Xu, Gayan Bamunuarachchi, Prince Jhandai, Keerthana Santhosh, Elizabeth Varghese, Lin Liu   +9 more
wiley   +1 more source

Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism

Viruses
Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (
Shih-Yen Lo, Meng-Jiun Lai, Chee-Hing Yang, Hui-Chun Li   +3 more
doaj   +1 more source

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source