Results 61 to 70 of about 45,192 (224)

Antimalarial flavonoid glycoside from Carica papaya with inhibitory potential against Plasmodium falciparum dihydrofolate reductase thymidylate synthase: an in-silico study

Universa Medicina
BACKGROUND Carica papaya is traditionally used to treat malaria. The mechanism of action of the active constituents may be determined by molecular docking.
Dewa Ayu Agus Sri Laksemi, I Dewa Ayu Inten Dwi Primayanti, I Wayan Surudarma, Putu Ayu Asri Damayanti, Ni Made Pitri Susanti   +4 more
doaj   +1 more source

Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]

, 1987
Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core   +2 more sources

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase [PDF]

, 2013
BACKGROUND: Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfDHFR-TS) is a well-defined target of anti-malarial drug, such as pyrimethamine and cycloguanil. Emergence of malaria parasites resistant to these drugs has been shown to be
Natpasit Chaianantakul, Rachada Sirawaraporn, Worachart Sirawaraporn   +2 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase

Cell Death and Disease, 2021
Metformin, the first-line drug for type II diabetes, has recently been considered an anticancer agent. However, the molecular target and underlying mechanism of metformin’s anti-cancer effects remain largely unclear.
Yinghui Wang, Hui Lu, Linchong Sun, Xin Chen, Haoran Wei, Caixia Suo, Junru Feng, Mengqiu Yuan, Shengqi Shen, Weidong Jia, Ying Wang, Huafeng Zhang, Zijun Li, Xiuying Zhong, Ping Gao   +14 more
doaj   +1 more source

Dihydrofolate reductase of Streptococcus faecium II. Purification and some properties of two dihydrofolate reductases from the Amethopterin-resistant mutant, Streptococcus Faecium Var. Durans Strain A [PDF]

, 1968
From a single amethopterin-resistant organism, Streptococcus faecium var. durans strain A, two different dihydrofolate reductases have been obtained as essentially homogeneous proteins in good yield.
Blakley, R. L., Nixon, P. F.
core  

Synergistic Enhancement: Whole Wheat Substrate Improves Memory in Mice by Optimizing Folate Metabolism and Systemic Antioxidant Capacity

Food Bioengineering, EarlyView.
ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi, Songyi Lin, Meina Zhang, Yue Tang   +3 more
wiley   +1 more source

Import of apocytochrome c into the mitochondrial intermembrane space along a cytochrome c1 sorting pathway [PDF]

, 1990
The question of whether cytochrome c could be functionally sorted to the mitochondrial intermembrane space along a "conservative sorting" pathway was investigated using a fusion protein termed pLc1-c. pLc1-c contains 3-fold targeting information, namely,
Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A., Wienhues, Ulla   +3 more
core  

Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Methotrexate is widely used to treat ectopic pregnancy (EP). Concerns about its teratogenicity have led to uncertainty regarding the optimal interval before attempting conception. Guidelines recommend a 3‐month washout period, while the manufacturer advises 6 months. Evidence on the safety of early conception is limited.
Bar Rosh, Joul Hadad, Naomi Gronich
wiley   +1 more source

Thermal Adaptation of Dihydrofolate Reductase from the Moderate ThermophileGeobacillus stearothermophilus [PDF]

, 2014
The thermal melting temperature of dihydrofolate reductase from Geobacillus stearothermophilus (BsDHFR) is 30 °C higher than that of its homologue from the psychrophile Moritella profunda.
Andreotti G., Back J. F., Bogin O., Bystroff C., Charlton P. A., Charlton P. A., Dams T., Donk P. J., E. Joel Loveridge, Elcock A. H., Evans R. M., Fierke C. A., Guo J., Haney P., Hashizume S., Hédoux A., Jiannan Guo, Kim H. S., Klingeberg M., Koch R., Kumar S., Kumar S., Louis Y. P. Luk, Loveridge E. J., Loveridge E. J., Loveridge E. J., Loveridge E. J., Loveridge E. J., Loveridge E. J., Maglia G., Meinhold L., Nazina T. N., Ng T. M., Oyeyemi O. A., Oyeyemi O. A., Pace C. N., Rudolf K. Allemann, Russell R. J. M., Russell R. J. M., Salminen T., Sawaya M. R., Sola-Penna M., Stone S. R., Swanwick R. S., Thompson J. D., Vogt G., Vogt G., Walsh K. A. J., Watanabe K., Xiao L., Yadav J. K., Yip K. S. P., Yip K. S. P., Zakrzewski S. F., Zuber H.   +54 more
core   +1 more source