Results 71 to 80 of about 125,417 (229)

Inhibition of pteridine reductase 1 (PTR1) expression in Leishmania promastigotes using a full-length antisense construct [PDF]

, 2009
Leishmania exhibit many unusual features, one of which is the pteridine metabolic pathway essential for the growth for these parasites. Leishmania have evolved a complex and versatile pteridine salvage network capable of scavenging a wide array of ...
Nariman Mosaffa, Ali Haghighi, Mojgan Bandehpour, Fereydoun Mahboudi, Nushin Davoudi, Bahram Kazemi, Mehdi Mohebali, Farnaz Kheirandish   +7 more
core  

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Inhibition of Leishmania Major PTR1 Gene Expression by Anti-sense in Escherichia Coli [PDF]

Iranian Journal of Public Health, 2012
Background:Protozoa related to Trypanosome family including Leishmania,synthesize enzymes to escape from drug therapy.One of them is PTR1 that its enzymatic activity is similar to dihydrofolate reductase(DHFR)Dihydrofolate reductase - thymidylate ...
M Mohebali, F Mahboudi, A Haghighi, M Bandehpour, F Kheirandish, B Kazemi   +5 more
doaj   +2 more sources

INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME

Vitae, 2009
Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful ...
Diego A. ZABALA, Bibiana ECAVARRÍA, Alejandro MARTÍNEZ   +2 more
doaj  

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Quantitative Pharmacodynamic Analysis of Trimethoprim‐Sulfonamide Combination Activity Against Staphylococcus pseudintermedius

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Trimethoprim (TMP)‐sulfonamide combinations are widely used in veterinary medicine, yet the quantitative nature of their pharmacodynamic interaction remains incompletely characterised. This study investigated the interaction between TMP and sulfamethoxazole (SMX), sulfadiazine (SDZ) and sulfadimethoxine (SDMX) against two Staphylococcus ...
Andrew Mead, Alexis Viel, Marine Boulanger, Gudrun Overesch, Carl Ekstrand, Pierre‐Louis Toutain, Aude A. Ferran, Ludovic Pelligand   +7 more
wiley   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

The former annotated human pseudogene dihydrofolate reductase-like 1 ( DHFRL1 ) is expressed and functional

, 2011
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate ...
Christine Loscher, Anne Parle-McDermott, Kirsty O’Brien, Gráinne McEntee, Ciarán Ó’Fágáin, Nadia Ben Larbi, Stefano Minguzzi   +6 more
core   +1 more source

Inhibition of Dihydrofolate Reductase by Mofebutazon

Zeitschrift für Naturforschung C, 1993
Abstract Mofebutazon, Dihydrofolate Reductase, Non-Steroidal Antiinflammatory Drugs (NSAIDs) Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. An apparent for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron ...
E, Strehl, I, Schneider, E F, Elstner
openaire   +2 more sources