Results 71 to 80 of about 23,665 (170)

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

In-silico and in-vitro study of hydroxythioxanthone derivatives as a potential candidate for antibacterial agents

Results in Chemistry
A molecular docking study and molecular dynamics simulation were conducted to evaluate the inhibitory activity of hydroxythioxanthones against dihydrofolate reductase (DHFR) from Staphylococcus aureus and Bacillus subtilis proteins.
Lathifah Puji Hastuti, Faris Hermawan, Muhammad Eka Prastya, Teni Ernawati, Nicky Rahmana Putra, Jumina Jumina, Shabarni Gaffar, Savira Ekawardhani   +7 more
doaj   +1 more source

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis [version 1; referees: 2 approved]

F1000Research, 2015
Dihydrofolate reductase from Escherichia coli (ecDHFR) serves as a model system for investigating the role of protein dynamics in enzyme catalysis. We discuss calculations predicting a network of dynamic motions that is coupled to the chemical step ...
Amnon Kohen
doaj   +1 more source

Evolution of N‐terminal mechanical lability as a determinant for Type III secretion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
Katherine E. DaPron, Alexandre M. Plastow, Morgan R. Fink, Brandon Dzuba, Marc‐Andre LeBlanc, Thomas T. Perkins, Emad Tajkhorshid, Marcelo C. Sousa   +7 more
wiley   +1 more source

Cloning and expression of ricin a- and b-subunits genes in fusion constructions with dihydrofolate reductase gene in escheriсhia coli.

Тонкие химические технологии, 2007
Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli.
M. А. Gracheva, Z. М. Galushkina, N. N. Poletaeva, L. V. Verhovskaya, V. G. Lunin, V. I. Shvets   +5 more
doaj  

E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim

International Journal of Mycobacteriology, 2015
Background: Dihydrofolate reductase (DHFR) (dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis (Mtb). This study was carried out to analyze mutations in the dfrA gene amongst 20 clinical DNA samples
Archana Raju, Savita Kulkarni, M K Ray, M G.R Rajan, Mariam S Degani   +4 more
doaj   +1 more source

Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors

Food Technology and Biotechnology, 2009
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although structurally belonging to different classes, the majority
Iva Tatic, Zrinka Ivezic, Sanja Tomic, Jerka Dumic, Mihailo Banjanac   +4 more
doaj  

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

A single-domain protein catenane of dihydrofolate reductase. [PDF]

Natl Sci Rev, 2023
Fang J, Li T, Lee J, Im D, Xu L, Liu Y, Seo J, Zhang WB.   +7 more
europepmc   +1 more source

In search of dihydrofolate reductase [PDF]

Protein Science, 1996
openaire   +2 more sources