Results 91 to 100 of about 125,417 (229)

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad, Anam, Marcos V. Palmeira‐Mello, Sabir Khan, José Clayston Melo Pereira   +4 more
wiley   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

How Dihydrofolate Reductase Facilitates Protonation of Dihydrofolate

, 2016
Dihydrofolate Reductase (DHFR) catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate. On the basis of 10−12.5 ns molecular dynamics simulations of two conformations (closed and occluded) of the ternary DHFR/NADPH/H2F complex from Escherichia
Charles L. Brooks (61231), Thomas H. Rod (2491708)   +1 more
core   +1 more source

Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase

Molecular Therapy: Methods & Clinical Development, 2018
Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater control over transgene integration site, copy number, and expression—significant advantages over traditional vector-mediated gene therapy with random genome ...
Biswajit Paul, Guillermo S. Romano Ibarra, Nicholas Hubbard, Teresa Einhaus, Alexander Astrakhan, David J. Rawlings, Hans-Peter Kiem, Christopher W. Peterson   +7 more
doaj   +1 more source

Life without dihydrofolate reductase FolA

, 2003
International audienceReduced folate derivatives participate in numerous reactions of bacterial intermediary metabolism. Consequently, the well-characterized enzyme implicated in the formation of tetrahydrofolate - dihydrofolate reductase FolA - was ...
Myllykallio, H., Leduc, D., Liebl, Ursula, Filee, J.   +3 more
core   +1 more source

Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism

Viruses
Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (
Shih-Yen Lo, Meng-Jiun Lai, Chee-Hing Yang, Hui-Chun Li   +3 more
doaj   +1 more source

Heterogeneity in the specific activity and methotrexate sensitivity of dihydrofolate reductase from blast cells of acute myelogenous leukemia patients.

, 1985
Dihydrofolate reductase activity was found to be highly heterogeneous in terms of its specific activity and methotrexate sensitivity in the blast cells of patients with acute myelogenous leukemia.
J H Goldie, S Dedhar, D Fitz-Gibbons, G Phillips, D Hartley   +4 more
core   +1 more source

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis [version 1; referees: 2 approved]

F1000Research, 2015
Dihydrofolate reductase from Escherichia coli (ecDHFR) serves as a model system for investigating the role of protein dynamics in enzyme catalysis. We discuss calculations predicting a network of dynamic motions that is coupled to the chemical step ...
Amnon Kohen
doaj   +1 more source

Prevalence and genetic location of non-transferable trimethoprim resistant dihydrofolate reductase genes in South African commensal faecal isolates [PDF]

, 1995
In a recent survey of trimethoprim resistance, 357 Gram-negative aerobic organisms were isolated from healthy volunteers from rural and urban populations in South Africa.
Thomson, C J, Adrian, P V, Klugman, K P, Amyes, S G   +3 more
core  

In-silico and in-vitro study of hydroxythioxanthone derivatives as a potential candidate for antibacterial agents

Results in Chemistry
A molecular docking study and molecular dynamics simulation were conducted to evaluate the inhibitory activity of hydroxythioxanthones against dihydrofolate reductase (DHFR) from Staphylococcus aureus and Bacillus subtilis proteins.
Lathifah Puji Hastuti, Faris Hermawan, Muhammad Eka Prastya, Teni Ernawati, Nicky Rahmana Putra, Jumina Jumina, Shabarni Gaffar, Savira Ekawardhani   +7 more
doaj   +1 more source