Results 101 to 110 of about 45,192 (224)

The Amino Terminus of the Yeast F_1-ATPase β-Subunit Precursor Functions as a Mitochondrial Import Signal [PDF]

, 1986
The ATP2 gene of Saccharomyces cerevisiae codes for the cytoplasmically synthesized beta-subunit protein of the mitochondrial F1-ATPase. To define the amino acid sequence determinants necessary for the in vivo targeting and import of this protein into ...
Douglas, Michael G., Emr, Scott D., Garrett, Jinnie, Geller, Bruce L., Takeda, Masaharu, Vassarotti, Alessio   +5 more
core  

Cloning and expression of ricin a- and b-subunits genes in fusion constructions with dihydrofolate reductase gene in escheriсhia coli.

Тонкие химические технологии, 2007
Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli.
M. А. Gracheva, Z. М. Galushkina, N. N. Poletaeva, L. V. Verhovskaya, V. G. Lunin, V. I. Shvets   +5 more
doaj  

E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim

International Journal of Mycobacteriology, 2015
Background: Dihydrofolate reductase (DHFR) (dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis (Mtb). This study was carried out to analyze mutations in the dfrA gene amongst 20 clinical DNA samples
Archana Raju, Savita Kulkarni, M K Ray, M G.R Rajan, Mariam S Degani   +4 more
doaj   +1 more source

Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors

Food Technology and Biotechnology, 2009
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although structurally belonging to different classes, the majority
Iva Tatic, Zrinka Ivezic, Sanja Tomic, Jerka Dumic, Mihailo Banjanac   +4 more
doaj  

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Scientia Pharmaceutica, 2017
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in ...
Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul   +2 more
doaj   +1 more source

UA94/6/15 Student / Alumni Personal Papers WKU Dorris Hutchinson [PDF]

, 2015
Correspondence and publications created by and about the Dorris Hutchison during her time at Sloan-Kettering ...
WKU Archives
core   +1 more source

Translocation arrest by reversible folding of a precursor protein imported into mitochondria [PDF]

, 1989
Passage of precursor proteins through translocation contact sites of mitochondria was investigated by studying the import of a fusion protein consisting of the NH2-terminal 167 amino acids of yeast cytochrome b2 precursor and the complete mouse ...
Guiard, Bernard, Hartl, Franz-Ulrich, Herzog, Volker, Neupert, Walter, Rassow, Joachim, Wienhues, Ulla   +5 more
core  

Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo. [PDF]

, 2006
Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and ...
Bonnet, M, Cohuet, S, D'Alessandro, U, Guthmann, J P, Van Herp, M, Van Overmeir, C   +5 more
core   +2 more sources

Genetic Diversity of Dihydropteroate synthetase Gene (dhps) Of Plasmodium vivax in Hormozgan Province, Iran

Iranian Journal of Parasitology, 2016
Background: The present study was formulated in order to determine pol­ymorphism of dihydropteroate synthetase gene (dhps) of Plasmodium vivax (P. vivax) in Hormozgan Province, southern Iran and mutations at codons 382, 383, 512, 553, and 585 associated ...
Somayeh MAGHSOODLOORAD, Ali HAGHIGHI, Khojasteh SHARIFI SARASIABI, Niloofar TAGHIPOOR, Nahid HOSSEINZADEH, Latif GACHKAR, Ehsan NAZEMALHOSSEINI MOJARRAD, Elham MAGHSOODLOORAD   +7 more
doaj