Results 101 to 110 of about 125,417 (229)

Cloning and expression of ricin a- and b-subunits genes in fusion constructions with dihydrofolate reductase gene in escheriсhia coli.

Тонкие химические технологии, 2007
Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli.
M. А. Gracheva, Z. М. Galushkina, N. N. Poletaeva, L. V. Verhovskaya, V. G. Lunin, V. I. Shvets   +5 more
doaj  

E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim

International Journal of Mycobacteriology, 2015
Background: Dihydrofolate reductase (DHFR) (dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis (Mtb). This study was carried out to analyze mutations in the dfrA gene amongst 20 clinical DNA samples
Archana Raju, Savita Kulkarni, M K Ray, M G.R Rajan, Mariam S Degani   +4 more
doaj   +1 more source

Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors

Food Technology and Biotechnology, 2009
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although structurally belonging to different classes, the majority
Iva Tatic, Zrinka Ivezic, Sanja Tomic, Jerka Dumic, Mihailo Banjanac   +4 more
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Supplementary from Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

, 2009
Supplementary from Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer ...
Cristina Morales (83591), Maria Ribas (14873661), Miguel A. Peinado (8434719), Carlos Caldas (1042), Rosa Miró (15041757), Maria J. García (8706306), Mar Muñoz (15041760)   +6 more
core   +1 more source

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

Thermodynamic Characterization of the Interactions of Methotrexate with Dihydrofolate-Reductase by Quantitative Affinity-Chromatography

, 1988
Affinity chromatography on methotrexate-Sepharose has been used to evaluate dissociation constants for interactions of methotrexate with dihydrofolate reductase from Lactobacillus casei.
Waltham, MC, Nixon, PF, Holland, JW, Winzor, DJ   +3 more
core   +1 more source

Trimethoprim-induced elevation of dihydrofolate reductase activity in human leukocytes

, 1978
The administration of trimethoprim (TMP)--a diamino benzylpyrimidine compound which binds very tightly the bacterial dihydrofolate reductase--was accompanied by the appearance of measurable levels of dihydrofolate reductase in peripheral leukocytes from ...
AVERSA, Franco, A. Velardi, M.F. Martelli, P. Rambotti   +3 more
core  

Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase

, 2016
Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism ...
Jennifer M. Beierlein (2256478), David B. Bolstad (2403814), Adrienne E. Smith (2334346), Kathleen M. Frey (184875), Amy C. Anderson (184893), Tammy M. Joska (2403808), Phillip M. Pelphrey (2403811), Nigel D. Priestley (184888), Dennis L. Wright (184896)   +8 more
core   +1 more source

A DFT-based QSAR study on inhibition of human dihydrofolate reductase

, 2016
Diaminopyrimidine derivatives are frequently used as inhibitors of human dihydrofolate reductase, for example in treatment of patients whose immune system are affected by human immunodeficiency virus.
Karabulut, Sedat, Sizochenko, Natalia, Leszczynski, Jerzy   +2 more
core   +1 more source

Genetic Diversity of Dihydropteroate synthetase Gene (dhps) Of Plasmodium vivax in Hormozgan Province, Iran

Iranian Journal of Parasitology, 2016
Background: The present study was formulated in order to determine pol­ymorphism of dihydropteroate synthetase gene (dhps) of Plasmodium vivax (P. vivax) in Hormozgan Province, southern Iran and mutations at codons 382, 383, 512, 553, and 585 associated ...
Somayeh MAGHSOODLOORAD, Ali HAGHIGHI, Khojasteh SHARIFI SARASIABI, Niloofar TAGHIPOOR, Nahid HOSSEINZADEH, Latif GACHKAR, Ehsan NAZEMALHOSSEINI MOJARRAD, Elham MAGHSOODLOORAD   +7 more
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