Results 111 to 120 of about 125,417 (229)
, 1985 Refined crystal structures are reported for complexes of Escherichia coli and chicken dihydrofolate reductase containing the antibiotic trimethoprim (TMP).
Burridge, JM +9 more
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dihydrofolate reductase as a target of sulpha drugs
, 2006 International audienceSulpha drugs act as competitive inhibitors of p-amino benzoic acid, an intermediate in the de novo folate pathway. Dihydropteroate synthase condenses sulpha drugs into sulpha-dihydropteroate (sulpha-DHP), which competes with ...
Bolotin-Fukuhara, Monique +9 more
core +1 more source
Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis
, 2003 Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima has been studied by stopped flow spectroscopy. The reduction of dihydrofolate by NADPH showed a biphasic temperature dependence of the deuterium kinetic isotope effect.
Maglia, Giovanni +2 more
core +1 more source
Increased Thermal Stability of Site-Selectively Glycosylated Dihydrofolate Reductase
, 2005 Heat protection. The native conformation of many proteins can be stabilised against thermal denaturation by glycosylation. Here we show that the thermal stability of the naturally nonglycosylated enzyme, dihydrofolate reductase, can be increased ...
Swanwick, Richard S. +4 more
core +1 more source
, 1989 Gamma-fluoromethotrexate (FMTX) is a poorly glutamylated mimic of the anti-cancer drug methotrexate (MTX) which is useful in studies of the roles of MTX poly-[gamma]-glutamates.
McGuire, John J. +2 more
core +1 more source
Construction of a Synthetic Dihydrofolate reductase gene
, 1992 The goal of this research was to improve Dihydrofolate reductase (DHFR) as a selectable marker in a maize transformation system. To do this, molecular, tissue culture and transformation techniques were used to transiently express several DHFR proteins ...
Chase, Jennifer M.
core +1 more source
Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry. [PDF]
Protein Sci, 2023 Kazan IC, Mills JH, Ozkan SB.
europepmc +1 more source
Silver inhibition on recombinant flavin reductase from Citrobacter freundii A1 [PDF]
, 2012 In this study, the flavin reductase (Fre) of Citrobatter freundii A1 was expressed in E. coli DH5a host with 1 mM IPTG induction. This recombinant protein was fused to 6xHis-tag, thus promising easier IMAC purification of the expressed enzyme.
Mamat, Nor Sasha Izana
core
Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. [PDF]
Acta Crystallogr D Struct Biol, 2023 Kirkman T +5 more
europepmc +1 more source