Results 71 to 80 of about 23,186 (181)

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Scientia Pharmaceutica, 2017
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in ...
Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul   +2 more
doaj   +1 more source

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

Genetic Diversity of Dihydropteroate synthetase Gene (dhps) Of Plasmodium vivax in Hormozgan Province, Iran

Iranian Journal of Parasitology, 2016
Background: The present study was formulated in order to determine pol­ymorphism of dihydropteroate synthetase gene (dhps) of Plasmodium vivax (P. vivax) in Hormozgan Province, southern Iran and mutations at codons 382, 383, 512, 553, and 585 associated ...
Somayeh MAGHSOODLOORAD, Ali HAGHIGHI, Khojasteh SHARIFI SARASIABI, Niloofar TAGHIPOOR, Nahid HOSSEINZADEH, Latif GACHKAR, Ehsan NAZEMALHOSSEINI MOJARRAD, Elham MAGHSOODLOORAD   +7 more
doaj  

A single-domain protein catenane of dihydrofolate reductase. [PDF]

Natl Sci Rev, 2023
Fang J, Li T, Lee J, Im D, Xu L, Liu Y, Seo J, Zhang WB.   +7 more
europepmc   +1 more source

Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry. [PDF]

Protein Sci, 2023
Kazan IC, Mills JH, Ozkan SB.
europepmc   +1 more source

Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. [PDF]

Acta Crystallogr D Struct Biol, 2023
Kirkman T, Sketcher A, de Morais Barroso V, Ishida K, Tosin M, Dias MVB.   +5 more
europepmc   +1 more source

Elongation Factor P Modulates the Incorporation of Structurally Diverse Noncanonical Amino Acids into Escherichia coli Dihydrofolate Reductase. [PDF]

J Am Chem Soc, 2023
Daskalova SM, Dedkova LM, Maini R, Talukder P, Bai X, Chowdhury SR, Zhang C, Nangreave RC, Hecht SM.   +8 more
europepmc   +1 more source

Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing. [PDF]

Int J Mol Sci, 2023
Wińska P, Sobiepanek A, Pawlak K, Staniszewska M, Cieśla J.   +4 more
europepmc   +1 more source

Dihydrofolate Reductase [PDF]

, 2020
openaire   +1 more source

Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand. [PDF]

Acta Trop, 2023
Sangsri R, Choowongkomon K, Tuntipaiboontana R, Sugaram R, Boondej P, Sudathip P, Dondorp AM, Imwong M.   +7 more
europepmc   +1 more source