Results 71 to 80 of about 48,162 (258)
DmdA‐independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions
The FEBS Journal, EarlyView.The lag phase is crucial for resuming bacterial growth and can be shortened by fueling the methionine cycle with methyl groups from DMSP or other methylated compounds. While DmdA is the primary DMSP demethylase in Phaeobacter inhibens, stress activates additional enzymes like Bmt. This enzymatic flexibility allows bacteria to exit the lag phase rapidly,
Delia A. Narváez‐Barragán +2 more
wiley +1 more source
Inhibition of Leishmania Major PTR1 Gene Expression by Anti-sense in Escherichia Coli [PDF]
Iranian Journal of Public Health, 2012 Background:Protozoa related to Trypanosome family including Leishmania,synthesize enzymes to escape from drug therapy.One of them is PTR1 that its enzymatic activity is similar to dihydrofolate reductase(DHFR)Dihydrofolate reductase - thymidylate ...
M Mohebali +5 more
doaj +2 more sources
Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]
, 2013 Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer +34 more
core +1 more source
Pyrimethamine Triggers the Apoptotic Pathway in Mucoepidermoid Carcinoma in Cell‐Based Models
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Background Mucoepidermoid carcinoma (MEC) is the most prevalent salivary gland malignancy, with a poor prognosis in high‐grade tumors at diagnosis. This highlights the need for effective antitumor agents for treating MEC. Therefore, we aimed to investigate the antineoplastic efficacy of pyrimethamine (PYR), a Food and Drug Administration ...
Hyun‐Ji Kim +5 more
wiley +1 more source
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. [PDF]
, 2011 Protein stability is widely recognized as a major evolutionary constraint. However, the relation between mutation-induced perturbations of protein stability and biological fitness has remained elusive.
Eugene Shakhnovich, Shimon Bershtein
core +1 more source
New Phytologist, EarlyView.Summary One‐carbon (C1) metabolism, centered on the universal methyl donor S‐adenosyl methionine (SAM), plays critical roles in biosynthesis, redox regulation, and stress responses across plants and microbes. A recently proposed photosynthetic C1 pathway links SAM methyl groups directly to RuBisCO‐mediated CO2 assimilation and integrates with nitrogen ...
Kolby J. Jardine +6 more
wiley +1 more source
Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii [PDF]
, 1982 Background: The proteins of halophilic archaea require high salt concentrations both for stability and for activity, whereas they denature at low ionic strength. The structural basis for this phenomenon is not yet well understood.
Pieper, Ursula +3 more
core +5 more sources
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Cobalamin (vitamin B12) is an essential cofactor for two human enzymes, methionine synthase and methylmalonyl‐CoA mutase. Inborn errors of cobalamin metabolism (IECMs) are inherited genetic defects resulting in improper transport, modification, or utilization of cobalamin and include inherited methylmalonic acidurias, a group of IECMs most ...
Almut Heinken +5 more
wiley +1 more source
INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
Vitae, 2009 Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful ...
Diego A. ZABALA +2 more
doaj
Staphylococcus saprophyticus Recovered from Humans, Food, and Recreational Waters in Rio de Janeiro, Brazil. [PDF]
, 2017 Staphylococcus saprophyticus is an important agent of urinary tract infection (UTI) in young women, but information about this pathogen in human microbiota and in common environment is lacking. The aim of this study was to characterize S.
Botelho, Ana Carolina Nunes +14 more
core +3 more sources