Results 171 to 180 of about 9,730 (212)

Design, synthesis and biological evaluation of <i>N</i>-pyridinyl ureidobenzenesulfonates and their hydrochloride salts as novel water-soluble dihydroorotate dehydrogenase inhibitors inducing differentiation of acute myeloid leukemia cells. [PDF]

RSC Med Chem
Ouellette V, Bouzriba C, Chavez Alvarez AC, Hamel-Côté G, Fortin S.   +4 more
europepmc   +1 more source

POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase. [PDF]

Cell Death Dis
Peng Y, Zheng W, Chen Y, Lei X, Yang Z, Yang Y, Liang W, Sun K, Li G, Yu J.   +9 more
europepmc   +1 more source

Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replication. [PDF]

J Virol
Zhao B-q, Chen J, Chen J-X, Cheng Y, Zhou J-f, Bai J-s, Mao D-y, Zhou B.   +7 more
europepmc   +1 more source

Repurposing of Drug Bank Compounds against <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase as novel anti malarial drug candidates by Computational approaches. [PDF]

In Silico Pharmacol
Joshi P, Pandey P, Rawat S, Chandra S.
europepmc   +1 more source

The Equilibrium Constant of the Dihydroorotic Dehydrogenase Reaction

Journal of Biological Chemistry, 1961
G, KRAKOW, B, VENNESLAND
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Dihydroorotate dehydrogenase. I. General properties.

The Journal of biological chemistry, 1968
V, Aleman, P, Handler
openaire   +1 more source

A First in man study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of RP7214, a Dihydroorotate Dehydrogenase (DHODH) inhibitor in Healthy Subjects

, 2022
Nair A, Barde P, Routhu K, Viswanadha S, Veeraraghavan S, Vakkalanka S.   +5 more
europepmc   +1 more source

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Inhibitors of dihydroorotate dehydrogenase

Expert Opinion on Therapeutic Patents, 1999
Dihydroorotate dehydrogenase (DHODase) is the rate-limiting step in de novo pyrimidine biosynthesis, required for the proliferation of many cell types and for the growth of microorganisms. Inhibitors of this enzyme have potential as immunosuppressive agents for the prevention of organ transplant rejection, and for the treatment of autoimmune diseases ...
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A simple radioassay for dihydroorotate dehydrogenase

Analytical Biochemistry, 1978
Abstract A simple radioassay for dihydroorotate dehydrogenase (DHO-DHase; EC 1.3.3.1) has been developed. l -[ carboxy - 14 C]Dihydroorotate was prepared from [ carboxy - 14 C]orotic acid using DHO-DHase derived from Zymobacterium oroticum and was purified by elution from DEAE-Sephadex A-25 with 0.2 m ammonium formate, pH 7.
G W, Smithers, A M, Gero, W J, O'Sullivan   +2 more
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Dihydroorotate Dehydrogenase of Escherichia coli

2003
Dihydroorotate dehydrogenase (DHOD) catalyzes the fourth reaction in the pathway for de novo synthesis of UMP and forms the 5,6-double bond of the pyrimidine base. In this reaction, two electrons and two protons are transferred from dihydroorotate to an electron acceptor that varies between different types of the enzyme.
Jensen, Kaj Frank, Larsen, Sine
openaire   +3 more sources