Results 231 to 240 of about 45,447 (273)

Coumarin 1,4-Dihydropyridine Derivatives

Bioorganic & Medicinal Chemistry, 1998
A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompanied by a decrease of the activity on myocardial and vascular ...
Valenti P., Rampa A., Budriesi R., Bisi A., Chiarini A.   +4 more
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(Trihalogenmethyl)dihydropyridine

Chemische Berichte, 1977
Abstract1‐(2,6‐Dichlorbenzyl)‐ und 1‐Ethylpyridinium‐Salze ergeben mit Haloformat‐Anionen (Trihalogenmethyl)dihydropyridine. Je nach dem verwendeten Haloform werden primär nur die 1,2‐ oder die 1,4‐Dihydropyridine gebildet. Die 2‐(Trichlormethyl)‐1,2‐dihydropyridine 1 lagern sich in polaren, aprotischen Lösungsmitteln in die 4‐(Trichlormethyl)‐1,4 ...
Karl Heinz Duchardt, Fritz Kröhnke
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ChemInform Abstract: 1,2‐Dihydropyridines, 1,4‐Dihydropyridines, and Derivatives

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J.‐C. Quirion, E. Leclerc, P. Jubault
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Thiophene substituted dihydropyridines

Journal of Chemical Crystallography, 2000
The crystal structures of 4-(2-thiophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxy-carbonyl) (I)[a = 10.273(5) A, b = 10.428(5) A, c = 14.799(9) A, β = 98.13(4)°, P21/c], 4-(3-thiophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxycarbonyl) (II)[a = 10.636(9) A, b = 10.372(8) A, c = 15.043(15) A, β = 98.13(6)°, P21/c], and 4-(2-thiophenyl)
Gregori A. Caignan, Sara K. Metcalf, Elizabeth M. Holt   +2 more
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ChemInform Abstract: DIHYDROPYRIDINE 24. MITT. POLAROGRAPHISCHE RED. EINIGER DIHYDROPYRIDINE

Chemischer Informationsdienst. Organische Chemie, 1971
AbstractDie Halbstufenpotentiale der Dihydropyridine (I)‐(IV) werden ermittelt; alle Stufen sind pH‐abhängig und entsprechen einer typisch irreversiblen Reduktion.
J. KUTHAN, V. SIMONEK, V. VOLKOVA, J. VOLKE   +3 more
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Dihydropyridines on guinea-pig ileum

General Pharmacology: The Vascular System, 1990
1. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM).
I, Martin, I, Colado, V, del Val, M J, Alfaro   +3 more
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Antioxidant activity of different dihydropyridines

Biochemical and Biophysical Research Communications, 2003
Lacidipine, a dihydropyridine-based calcium antagonist (DHP), has already been demonstrated to possess antioxidant activity and to reduce the intracellular production of reactive oxygen species (ROS). To verify if this effect is a peculiarity of this molecule, or belongs to other DHPs, the activity of lacidipine was compared with those of amlodipine ...
COMINACINI, Luciano, FRATTA PASINI, Anna Maria, GARBIN, Ulisse, PASTORINO AM, DAVOLI A, NAVA, Maria Cristina, CAMPAGNOLA M, ROSSATO P, LO CASCIO, Vincenzo   +8 more
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Antihypertensive dihydropyridines with 1,4,4-trisubstitution

Journal of Medicinal Chemistry, 1990
Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds.
M J, Kukla, H J, Breslin, A, Gill
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Hantzsch dihydropyridine synthesis

2009
1,4-Dihydropyridine from the condensation of aldehyde, β-ketoester and ammonia. Hantzsch 1,4-dihydropyridines are popular reducing reagents in organo-catalysis.
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1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
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