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Screening for Dihydropyrimidine Dehydrogenase Deficiency
Clinical Cancer Research, 2005In the presence of NADPH, dihydropryimidine dehydrogenase (DPD) catalyzes the rate-limiting step in the catabolism of pyrimidine bases, including uracil, thymine, and the anticancer agent 5-fluorouracil (5-FU; [Fig. 1][1]). Following bolus and continuous infusion administration of 5-FU, about 90%
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Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase
European Journal of Cancer, 1994before injection, no differences in colony numbers were shown. These results suggest that different AML progenitor cells can be defined in the whole AML population, dependent on the test system used. Moreover, the findings indicate a hierarchy in AML progenitors, including cells with short-term and longterm repopulating abilities, as has already been ...
G J, Peters +2 more
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The Effect of Dihydropyrimidine Dehydrogenase Deficiency on Outcomes with Fluorouracil
Adverse Drug Reactions and Toxicological Reviews, 2002The use of fluorouracil has been complicated by unpredictable pharmacokinetics, low response rates and seemingly random toxicity. The variable pharmacology is largely due to inherited differences in expression of the metabolising enzyme dihydropyrimidine dehydrogenase (DPD).
Sharon J, Gardiner +2 more
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Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping
Journal of Clinical Oncology, 2016Teresa, Magnes +5 more
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Dihydropyrimidine dehydrogenase deficiency
Journal of the Neurological Sciences, 1987J.P. Braakhekke +5 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 2002
The rate-limiting enzyme to catabolize 5-fluorouracil (5-FU) is dihydropyrimidine dehydrogenase (DPD), which expression in cancerous tissue is reported to have a relation with anti-tumor effect for 5-FU. In this study, we evaluated the immunohistochemical expression in gastric cancer using two different kinds of anti-human DPD antibody, KM1915 and ...
Kuniaki, Kitago +3 more
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The rate-limiting enzyme to catabolize 5-fluorouracil (5-FU) is dihydropyrimidine dehydrogenase (DPD), which expression in cancerous tissue is reported to have a relation with anti-tumor effect for 5-FU. In this study, we evaluated the immunohistochemical expression in gastric cancer using two different kinds of anti-human DPD antibody, KM1915 and ...
Kuniaki, Kitago +3 more
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Dihydropyrimidine Dehydrogenase Deficiency
2009van Kuilenburg, André B. P. +1 more
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