Results 201 to 210 of about 3,167 (267)

SAR studies on dihydropyrimidinone antibiotics

Bioorganic & Medicinal Chemistry Letters, 2011
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing ...
Lianhong, Xu, Lijun, Zhang, Robert, Jones, Clifford, Bryant, Nina, Boddeker, Eric, Mabery, Gina, Bahador, Julia, Watson, Jeffery, Clough, Murty, Arimilli, Wendy, Gillette, Dorothy, Colagiovanni, Keyu, Wang, Craig, Gibbs, Choung U, Kim   +14 more
openaire   +2 more sources

Dihydropyrimidinones as potent anticancer agents: Insight into the structure–activity relationship

Archiv der Pharmazie, 2023
Cancer is a serious disease that has been around for a long time but currently has no sustainable solution. Several medications currently available offer an opportunity for the manifestation of cancer treatment; however, the “search for better” has led ...
T. Prasad, Aastha Mahapatra, Tripti Sharma, C. R. Sahoo, R. Padhy   +4 more
semanticscholar   +1 more source

Dihydropyrimidinones containing boronic acids

Canadian Journal of Chemistry, 2005
The addition of formylphenylboronic acid derivatives to urea and ethyl acetoacetate proceeds in the absence of an additional Lewis acid catalyst to give the corresponding dihydropyrimidinones (Biginelli products) in good yields. Novel boron-containing dihydropyrimidinones have been investigated for their ability to act as anticancer agents against the
Johanna M Blacquiere, Oana Sicora, Christopher M Vogels, Miroslava Čuperlović-Culf, Andreas Decken, Rodney J Ouellette, Stephen A Westcott   +6 more
openaire   +1 more source

Sonochemical synthesis of l,4-dihydropyrimidinones catalyzed by reduced graphene oxide encapsulated zinc oxide nanoparticles

Inorganic and Nano-Metal Chemistry, 2023
A simple and efficient one-pot procedure for the synthesis of 1,4-dihydropyrimidinones in ethanol under ultrasound irradiation is described. These heterocyclic compounds were prepared through condensation of aromatic aldehyde, ethyl acetoacetate, urea ...
Leila Hemmesi, H. Naeimi
semanticscholar   +1 more source

The Biginelli Dihydropyrimidinone Synthesis

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
C. Oliver Kappe, Alexander Stadler
openaire   +1 more source

Stereoselective synthesis of new dihydropyrimidinone glycoconjugates #

Journal of Heterocyclic Chemistry, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
G. V. M. Sharma, K. Laxmi Reddy, P. Sree Lakshmi, Palakodety Radha Krishna   +3 more
openaire   +1 more source

A Versatile Synthesis of DihydropyrimidinoneC‐Nucleosides

Nucleosides, Nucleotides and Nucleic Acids, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ram Chandra, Mishra, Diksha, Katiyar, Neetu, Tewari, Rama Pati, Tripathi   +3 more
openaire   +2 more sources

Recent Advance in the Pharmacology of Dihydropyrimidinone

Mini-Reviews in Medicinal Chemistry, 2012
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and ...
J-P, Wan, Y, Pan
openaire   +2 more sources

Reaction Optimization of Strontium Perchlorate Catalyzed Novel Protocol for Stereoselective Synthesis of Dihydropyrimidinones.

Current Organic Synthesis, 2023
BACKGROUND Hydrated strontium perchlorate [Sr(ClO4)2.3H2O] acts as a very strong oxidizing and dehydrating agent. Until now, it could not be reported as a catalyst in dehydration mechanism-based organic synthetic reactions.
D. Chauhan, H. Chopra, S. Nayak
semanticscholar   +1 more source

Dihydropyrimidinones—a new class of anti-Staphylococcal antibiotics

Bioorganic & Medicinal Chemistry Letters, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael, Brands, Rainer, Endermann, Reinhold, Gahlmann, Jochen, Krüger, Siegfried, Raddatz   +4 more
openaire   +2 more sources